3IF9
Crystal structure of Glycine Oxidase G51S/A54R/H244A mutant in complex with inhibitor glycolate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0009228 | biological_process | thiamine biosynthetic process |
| A | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| A | 0009635 | biological_process | response to herbicide |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0043799 | molecular_function | glycine oxidase activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0071949 | molecular_function | FAD binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0009228 | biological_process | thiamine biosynthetic process |
| B | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| B | 0009635 | biological_process | response to herbicide |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0043799 | molecular_function | glycine oxidase activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0071949 | molecular_function | FAD binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0009228 | biological_process | thiamine biosynthetic process |
| C | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| C | 0009635 | biological_process | response to herbicide |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0043799 | molecular_function | glycine oxidase activity |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0071949 | molecular_function | FAD binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0009228 | biological_process | thiamine biosynthetic process |
| D | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| D | 0009635 | biological_process | response to herbicide |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0043799 | molecular_function | glycine oxidase activity |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOA A 370 |
| Chain | Residue |
| A | TYR246 |
| A | ARG302 |
| A | ARG329 |
| A | FAD371 |
| site_id | AC2 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE FAD A 371 |
| Chain | Residue |
| A | SER35 |
| A | THR42 |
| A | THR43 |
| A | ALA46 |
| A | ALA47 |
| A | GLY48 |
| A | MET49 |
| A | PRO173 |
| A | VAL174 |
| A | SER202 |
| A | GLY203 |
| A | MET208 |
| A | PHE209 |
| A | CYS226 |
| A | TYR246 |
| A | GLY300 |
| A | ARG302 |
| A | HIS327 |
| A | PHE328 |
| A | ARG329 |
| A | ASN330 |
| A | GLY331 |
| A | ILE332 |
| A | LEU333 |
| A | GOA370 |
| A | HOH373 |
| A | HOH374 |
| A | HOH379 |
| A | HOH383 |
| A | HOH402 |
| A | GLY11 |
| A | GLY13 |
| A | ILE14 |
| A | ILE15 |
| A | GLU34 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOA B 370 |
| Chain | Residue |
| B | TYR246 |
| B | ARG302 |
| B | ARG329 |
| B | FAD371 |
| site_id | AC4 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE FAD B 371 |
| Chain | Residue |
| B | GLY11 |
| B | GLY13 |
| B | ILE14 |
| B | ILE15 |
| B | PHE33 |
| B | GLU34 |
| B | SER35 |
| B | ARG41 |
| B | THR42 |
| B | THR43 |
| B | ALA45 |
| B | ALA46 |
| B | ALA47 |
| B | GLY48 |
| B | MET49 |
| B | PRO173 |
| B | VAL174 |
| B | SER202 |
| B | GLY203 |
| B | TRP205 |
| B | MET208 |
| B | PHE209 |
| B | TYR246 |
| B | GLY300 |
| B | ARG302 |
| B | HIS327 |
| B | PHE328 |
| B | ARG329 |
| B | ASN330 |
| B | GLY331 |
| B | ILE332 |
| B | LEU333 |
| B | GOA370 |
| B | HOH372 |
| B | HOH374 |
| B | HOH380 |
| B | HOH403 |
| B | HOH412 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOA C 370 |
| Chain | Residue |
| C | TYR246 |
| C | ARG302 |
| C | ARG329 |
| C | FAD371 |
| site_id | AC6 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD C 371 |
| Chain | Residue |
| C | VAL174 |
| C | SER202 |
| C | GLY203 |
| C | TRP205 |
| C | CYS226 |
| C | TYR246 |
| C | GLY300 |
| C | ARG302 |
| C | HIS327 |
| C | PHE328 |
| C | ARG329 |
| C | ASN330 |
| C | GLY331 |
| C | ILE332 |
| C | LEU333 |
| C | GOA370 |
| C | HOH372 |
| C | HOH373 |
| C | HOH374 |
| C | HOH381 |
| C | HOH390 |
| C | HOH404 |
| C | GLY11 |
| C | GLY13 |
| C | ILE14 |
| C | ILE15 |
| C | PHE33 |
| C | GLU34 |
| C | SER35 |
| C | ARG41 |
| C | THR42 |
| C | THR43 |
| C | ALA46 |
| C | ALA47 |
| C | GLY48 |
| C | MET49 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOA D 370 |
| Chain | Residue |
| D | TYR246 |
| D | ALA259 |
| D | ARG302 |
| D | ARG329 |
| D | FAD371 |
| site_id | AC8 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD D 371 |
| Chain | Residue |
| D | GLY11 |
| D | GLY12 |
| D | GLY13 |
| D | ILE14 |
| D | ILE15 |
| D | PHE33 |
| D | GLU34 |
| D | SER35 |
| D | ARG41 |
| D | THR42 |
| D | THR43 |
| D | ALA46 |
| D | ALA47 |
| D | GLY48 |
| D | MET49 |
| D | VAL174 |
| D | SER202 |
| D | GLY203 |
| D | TRP205 |
| D | MET208 |
| D | CYS226 |
| D | TYR246 |
| D | GLY300 |
| D | ARG302 |
| D | HIS327 |
| D | PHE328 |
| D | ARG329 |
| D | ASN330 |
| D | GLY331 |
| D | ILE332 |
| D | LEU333 |
| D | GOA370 |
| D | HOH378 |
| D | HOH389 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12627963, ECO:0000269|PubMed:15105420, ECO:0000269|PubMed:19864430 |
| Chain | Residue | Details |
| A | ILE14 | |
| B | ALA47 | |
| B | VAL174 | |
| B | HIS327 | |
| C | ILE14 | |
| C | GLU34 | |
| C | THR42 | |
| C | ALA47 | |
| C | VAL174 | |
| C | HIS327 | |
| D | ILE14 | |
| A | GLU34 | |
| D | GLU34 | |
| D | THR42 | |
| D | ALA47 | |
| D | VAL174 | |
| D | HIS327 | |
| A | THR42 | |
| A | ALA47 | |
| A | VAL174 | |
| A | HIS327 | |
| B | ILE14 | |
| B | GLU34 | |
| B | THR42 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12627963 |
| Chain | Residue | Details |
| A | ARG302 | |
| A | ARG329 | |
| B | ARG302 | |
| B | ARG329 | |
| C | ARG302 | |
| C | ARG329 | |
| D | ARG302 | |
| D | ARG329 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1c0k |
| Chain | Residue | Details |
| A | ARG329 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1c0k |
| Chain | Residue | Details |
| B | ARG329 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1c0k |
| Chain | Residue | Details |
| C | ARG329 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1c0k |
| Chain | Residue | Details |
| D | ARG329 |
