3IBJ

X-ray structure of PDE2A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	HIS660
A	HIS696
A	ASP697
A	ASP808

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 905

Chain	Residue
A	ASP697
A	THR768

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	ASP808
B	MG905
B	HIS660
B	HIS696
B	ASP697

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 905

Chain	Residue
B	ZN2
B	ASP697

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF

Chain	Residue	Details
A	HIS696-PHE707

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083

Chain	Residue	Details
A	HIS656
B	HIS656

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q922S4

Chain	Residue	Details
A	SER431
B	THR499
A	ASP446
A	ILE465
A	TYR488
A	THR499
B	SER431
B	ASP446
B	ILE465
B	TYR488

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:15938621, ECO:0000269|PubMed:19828435, ECO:0000269|PubMed:23899287, ECO:0007744|PDB:1Z1L, ECO:0007744|PDB:3IBJ, ECO:0007744|PDB:3ITM, ECO:0007744|PDB:3ITU, ECO:0007744|PDB:4HTX, ECO:0007744|PDB:4HTZ, ECO:0007744|PDB:4JIB

Chain	Residue	Details
A	HIS660
A	ASP697
A	ASP808
B	HIS660
B	ASP697
B	ASP808

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15938621, ECO:0000269|PubMed:19828435, ECO:0000269|PubMed:23899287, ECO:0007744|PDB:1Z1L, ECO:0007744|PDB:3ITM, ECO:0007744|PDB:3ITU, ECO:0007744|PDB:4HTX, ECO:0007744|PDB:4HTZ, ECO:0007744|PDB:4JIB

Chain	Residue	Details
A	HIS696
B	HIS696

---