3IA3
A cis-proline in alpha-hemoglobin stabilizing Protein directs the structural reorganization of alpha-hemoglobin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006457 | biological_process | protein folding |
| A | 0030218 | biological_process | erythrocyte differentiation |
| A | 0030492 | molecular_function | hemoglobin binding |
| A | 0050821 | biological_process | protein stabilization |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005344 | molecular_function | oxygen carrier activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005829 | cellular_component | cytosol |
| B | 0005833 | cellular_component | hemoglobin complex |
| B | 0015670 | biological_process | carbon dioxide transport |
| B | 0015671 | biological_process | oxygen transport |
| B | 0016020 | cellular_component | membrane |
| B | 0019825 | molecular_function | oxygen binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0030185 | biological_process | nitric oxide transport |
| B | 0031720 | molecular_function | haptoglobin binding |
| B | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| B | 0042542 | biological_process | response to hydrogen peroxide |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0043177 | molecular_function | organic acid binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071682 | cellular_component | endocytic vesicle lumen |
| B | 0072562 | cellular_component | blood microparticle |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0006457 | biological_process | protein folding |
| C | 0030218 | biological_process | erythrocyte differentiation |
| C | 0030492 | molecular_function | hemoglobin binding |
| C | 0050821 | biological_process | protein stabilization |
| D | 0004601 | molecular_function | peroxidase activity |
| D | 0005344 | molecular_function | oxygen carrier activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005829 | cellular_component | cytosol |
| D | 0005833 | cellular_component | hemoglobin complex |
| D | 0015670 | biological_process | carbon dioxide transport |
| D | 0015671 | biological_process | oxygen transport |
| D | 0016020 | cellular_component | membrane |
| D | 0019825 | molecular_function | oxygen binding |
| D | 0020037 | molecular_function | heme binding |
| D | 0030185 | biological_process | nitric oxide transport |
| D | 0031720 | molecular_function | haptoglobin binding |
| D | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| D | 0042542 | biological_process | response to hydrogen peroxide |
| D | 0042744 | biological_process | hydrogen peroxide catabolic process |
| D | 0043177 | molecular_function | organic acid binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0071682 | cellular_component | endocytic vesicle lumen |
| D | 0072562 | cellular_component | blood microparticle |
| D | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE HEM B 201 |
| Chain | Residue |
| B | PHE43 |
| B | VAL93 |
| B | ASN97 |
| B | PHE98 |
| B | LEU101 |
| B | SER102 |
| D | PRO77 |
| D | ASN78 |
| D | ALA79 |
| B | HIS45 |
| B | PHE46 |
| B | HIS58 |
| B | LYS61 |
| B | VAL62 |
| B | ALA65 |
| B | LEU83 |
| B | HIS87 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE HEM D 201 |
| Chain | Residue |
| B | MET76 |
| B | PRO77 |
| B | ASN78 |
| B | ALA79 |
| D | PHE43 |
| D | HIS45 |
| D | PHE46 |
| D | HIS58 |
| D | LYS61 |
| D | VAL62 |
| D | ALA65 |
| D | LEU83 |
| D | HIS87 |
| D | VAL93 |
| D | ASN97 |
| D | PHE98 |
| D | LEU101 |
| D | SER102 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00238 |
| Chain | Residue | Details |
| B | HIS58 | |
| D | HIS58 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: proximal binding residue => ECO:0000255|PROSITE-ProRule:PRU00238 |
| Chain | Residue | Details |
| B | HIS87 | |
| D | HIS87 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | SITE: (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 |
| Chain | Residue | Details |
| B | THR8 | |
| B | LEU91 | |
| B | LEU106 | |
| B | THR108 | |
| B | VAL121 | |
| B | SER133 | |
| D | THR8 | |
| D | ALA13 | |
| D | TYR24 | |
| D | LEU29 | |
| D | HIS45 | |
| B | ALA13 | |
| D | ASP47 | |
| D | SER52 | |
| D | VAL55 | |
| D | GLY59 | |
| D | LEU91 | |
| D | LEU106 | |
| D | THR108 | |
| D | VAL121 | |
| D | SER133 | |
| B | TYR24 | |
| B | LEU29 | |
| B | HIS45 | |
| B | ASP47 | |
| B | SER52 | |
| B | VAL55 | |
| B | GLY59 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:7358733 |
| Chain | Residue | Details |
| B | LYS11 | |
| D | LYS99 | |
| B | LYS56 | |
| B | LYS60 | |
| B | LYS90 | |
| B | LYS99 | |
| D | LYS11 | |
| D | LYS56 | |
| D | LYS60 | |
| D | LYS90 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER3 | |
| B | SER35 | |
| B | SER49 | |
| D | SER3 | |
| D | SER35 | |
| D | SER49 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P01942 |
| Chain | Residue | Details |
| B | LYS7 | |
| B | LYS16 | |
| B | LYS40 | |
| D | LYS7 | |
| D | LYS16 | |
| D | LYS40 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | THR8 | |
| D | THR8 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P01942 |
| Chain | Residue | Details |
| B | LYS11 | |
| D | LYS11 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | TYR24 | |
| D | TYR24 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P01942 |
| Chain | Residue | Details |
| B | SER102 | |
| B | SER124 | |
| B | SER131 | |
| B | SER138 | |
| D | SER102 | |
| D | SER124 | |
| D | SER131 | |
| D | SER138 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P01942 |
| Chain | Residue | Details |
| B | THR108 | |
| B | THR134 | |
| B | THR137 | |
| D | THR108 | |
| D | THR134 | |
| D | THR137 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 |
| Chain | Residue | Details |
| B | LYS7 | |
| B | LYS16 | |
| B | LYS40 | |
| D | LYS7 | |
| D | LYS16 | |
| D | LYS40 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 |
| Chain | Residue | Details |
| B | LYS61 | |
| D | LYS61 |
