3I9G

Crystal structure of the LT1009 (SONEPCIZUMAB) antibody Fab fragment in complex with sphingosine-1-phosphate

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA L 301

Chain	Residue
L	ASP30
L	ASP31
L	ASP32
L	S1P401
L	HOH501
L	HOH504

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA L 302

Chain	Residue
L	S1P401
L	HOH502
L	HOH503
L	ASP30
L	ASP32
L	ASP92

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG L 303

Chain	Residue
L	SER12
L	ASP92
L	LYS107
L	HOH658

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG L 305

Chain	Residue
H	TYR59
H	ARG64

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG L 307

Chain	Residue
H	ASP208

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE S1P L 401

Chain	Residue
H	THR33
H	GLY99
H	SER100
L	ASP30
L	ASP32
L	GLU50
L	SER91
L	ASP92
L	LEU94
L	CA301
L	CA302
L	HOH502
L	HOH503
L	HOH504
L	HOH505
L	HOH506

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR192-HIS198
H	TYR194-HIS200

---