Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3I8E

Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR42A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000781	cellular_component	chromosome, telomeric region
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006974	biological_process	DNA damage response
A	0007056	biological_process	spindle assembly involved in female meiosis
A	0007283	biological_process	spermatogenesis
A	0008283	biological_process	cell population proliferation
A	0010498	biological_process	proteasomal protein catabolic process
A	0010506	biological_process	regulation of autophagy
A	0016567	biological_process	protein ubiquitination
A	0019076	biological_process	viral release from host cell
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031297	biological_process	replication fork processing
A	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
A	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
A	0032814	biological_process	regulation of natural killer cell activation
A	0032991	cellular_component	protein-containing complex
A	0034644	biological_process	cellular response to UV
A	0035861	cellular_component	site of double-strand break
A	0040029	biological_process	epigenetic regulation of gene expression
A	0042127	biological_process	regulation of cell population proliferation
A	0042752	biological_process	regulation of circadian rhythm
A	0042981	biological_process	regulation of apoptotic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0044725	biological_process	epigenetic programming in the zygotic pronuclei
A	0044877	molecular_function	protein-containing complex binding
A	0045070	biological_process	positive regulation of viral genome replication
A	0045722	biological_process	positive regulation of gluconeogenesis
A	0045732	biological_process	positive regulation of protein catabolic process
A	0045995	biological_process	regulation of embryonic development
A	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
A	0048511	biological_process	rhythmic process
A	0051702	biological_process	biological process involved in interaction with symbiont
A	0060964	biological_process	regulation of miRNA-mediated gene silencing
A	0070062	cellular_component	extracellular exosome
A	0070914	biological_process	UV-damage excision repair
A	0071987	molecular_function	WD40-repeat domain binding
A	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
A	0080135	biological_process	regulation of cellular response to stress
A	0097602	molecular_function	cullin family protein binding
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
A	1901987	biological_process	regulation of cell cycle phase transition
A	1901990	biological_process	regulation of mitotic cell cycle phase transition
A	1902412	biological_process	regulation of mitotic cytokinesis
A	1904178	biological_process	negative regulation of adipose tissue development
A	2000036	biological_process	regulation of stem cell population maintenance
B	0000781	cellular_component	chromosome, telomeric region
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0006281	biological_process	DNA repair
B	0006289	biological_process	nucleotide-excision repair
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006974	biological_process	DNA damage response
B	0007056	biological_process	spindle assembly involved in female meiosis
B	0007283	biological_process	spermatogenesis
B	0008283	biological_process	cell population proliferation
B	0010498	biological_process	proteasomal protein catabolic process
B	0010506	biological_process	regulation of autophagy
B	0016567	biological_process	protein ubiquitination
B	0019076	biological_process	viral release from host cell
B	0030174	biological_process	regulation of DNA-templated DNA replication initiation
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0031297	biological_process	replication fork processing
B	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
B	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
B	0032814	biological_process	regulation of natural killer cell activation
B	0032991	cellular_component	protein-containing complex
B	0034644	biological_process	cellular response to UV
B	0035861	cellular_component	site of double-strand break
B	0040029	biological_process	epigenetic regulation of gene expression
B	0042127	biological_process	regulation of cell population proliferation
B	0042752	biological_process	regulation of circadian rhythm
B	0042981	biological_process	regulation of apoptotic process
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0044725	biological_process	epigenetic programming in the zygotic pronuclei
B	0044877	molecular_function	protein-containing complex binding
B	0045070	biological_process	positive regulation of viral genome replication
B	0045722	biological_process	positive regulation of gluconeogenesis
B	0045732	biological_process	positive regulation of protein catabolic process
B	0045995	biological_process	regulation of embryonic development
B	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
B	0048511	biological_process	rhythmic process
B	0051702	biological_process	biological process involved in interaction with symbiont
B	0060964	biological_process	regulation of miRNA-mediated gene silencing
B	0070062	cellular_component	extracellular exosome
B	0070914	biological_process	UV-damage excision repair
B	0071987	molecular_function	WD40-repeat domain binding
B	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
B	0080135	biological_process	regulation of cellular response to stress
B	0097602	molecular_function	cullin family protein binding
B	0160072	molecular_function	ubiquitin ligase complex scaffold activity
B	1901987	biological_process	regulation of cell cycle phase transition
B	1901990	biological_process	regulation of mitotic cell cycle phase transition
B	1902412	biological_process	regulation of mitotic cytokinesis
B	1904178	biological_process	negative regulation of adipose tissue development
B	2000036	biological_process	regulation of stem cell population maintenance

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1532
Details	Region: {"description":"Interaction with CDT1","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	686
Details	Region: {"description":"WD repeat beta-propeller A"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	632
Details	Region: {"description":"WD repeat beta-propeller B; Interaction with CUL4A"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)