Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 1261 |
| Chain | Residue |
| A | HIS222 |
| A | HIS226 |
| A | HIS232 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1262 |
| Chain | Residue |
| A | HIS172 |
| A | ASP174 |
| A | HIS187 |
| A | HIS200 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 1263 |
| Chain | Residue |
| A | ASP203 |
| A | GLU205 |
| A | THR126 |
| A | ASP128 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1264 |
| Chain | Residue |
| A | ASP179 |
| A | GLY180 |
| A | SER182 |
| A | LEU184 |
| A | ASP202 |
| A | GLU205 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1265 |
| Chain | Residue |
| A | HOH2 |
| A | HOH46 |
| A | ASP162 |
| A | ASN194 |
| A | GLY196 |
| A | ASP198 |
| site_id | AC6 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE 518 A 999 |
| Chain | Residue |
| A | HOH24 |
| A | LEU156 |
| A | GLY183 |
| A | LEU185 |
| A | ALA186 |
| A | TYR214 |
| A | LEU218 |
| A | HIS222 |
| A | GLU223 |
| A | GLY237 |
| A | LEU239 |
| A | PHE241 |
| A | PRO242 |
| A | ILE243 |
| A | TYR244 |
| A | THR245 |
| A | THR247 |
| A | PHE252 |
| A | PRO255 |
| A | HOH318 |
| A | HOH336 |
| A | HOH338 |
| A | HOH359 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 2261 |
| Chain | Residue |
| B | HIS222 |
| B | HIS226 |
| B | HIS232 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 2262 |
| Chain | Residue |
| B | HIS172 |
| B | ASP174 |
| B | HIS187 |
| B | HIS200 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 2263 |
| Chain | Residue |
| A | ASP158 |
| B | ASP128 |
| B | ASP203 |
| B | GLU205 |
| B | HOH303 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 2264 |
| Chain | Residue |
| B | ASP179 |
| B | GLY180 |
| B | SER182 |
| B | LEU184 |
| B | ASP202 |
| B | GLU205 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 2265 |
| Chain | Residue |
| B | HOH29 |
| B | ALA161 |
| B | ASP162 |
| B | ASN194 |
| B | GLY196 |
| B | ASP198 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL |
| Chain | Residue | Details |
| A | VAL219-LEU228 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLU223 | |
| B | GLU223 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305 |
| Chain | Residue | Details |
| A | ASP128 | |
| A | ASP202 | |
| A | ASP203 | |
| A | GLU205 | |
| B | ASP128 | |
| B | ASP162 | |
| B | ASP179 | |
| B | GLY180 | |
| B | SER182 | |
| B | LEU184 | |
| B | ASN194 | |
| A | ASP162 | |
| B | GLY196 | |
| B | ASP198 | |
| B | ASP202 | |
| B | ASP203 | |
| B | GLU205 | |
| A | ASP179 | |
| A | GLY180 | |
| A | SER182 | |
| A | LEU184 | |
| A | ASN194 | |
| A | GLY196 | |
| A | ASP198 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860 |
| Chain | Residue | Details |
| A | HIS172 | |
| B | ASP174 | |
| B | HIS187 | |
| B | HIS200 | |
| B | HIS222 | |
| B | HIS226 | |
| B | HIS232 | |
| B | MET240 | |
| A | ASP174 | |
| A | HIS187 | |
| A | HIS200 | |
| A | HIS222 | |
| A | HIS226 | |
| A | HIS232 | |
| A | MET240 | |
| B | HIS172 | |
| Chain | Residue | Details |
| A | ASN117 | |
| B | ASN117 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN152 | |
| B | ASN152 | |
