3I3J

Crystal Structure of the Bromodomain of Human EP300

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0004402	molecular_function	histone acetyltransferase activity
B	0006355	biological_process	regulation of DNA-templated transcription
C	0004402	molecular_function	histone acetyltransferase activity
C	0006355	biological_process	regulation of DNA-templated transcription
D	0004402	molecular_function	histone acetyltransferase activity
D	0006355	biological_process	regulation of DNA-templated transcription
E	0004402	molecular_function	histone acetyltransferase activity
E	0006355	biological_process	regulation of DNA-templated transcription
F	0004402	molecular_function	histone acetyltransferase activity
F	0006355	biological_process	regulation of DNA-templated transcription
G	0004402	molecular_function	histone acetyltransferase activity
G	0006355	biological_process	regulation of DNA-templated transcription
H	0004402	molecular_function	histone acetyltransferase activity
H	0006355	biological_process	regulation of DNA-templated transcription
I	0004402	molecular_function	histone acetyltransferase activity
I	0006355	biological_process	regulation of DNA-templated transcription
J	0004402	molecular_function	histone acetyltransferase activity
J	0006355	biological_process	regulation of DNA-templated transcription
K	0004402	molecular_function	histone acetyltransferase activity
K	0006355	biological_process	regulation of DNA-templated transcription
L	0004402	molecular_function	histone acetyltransferase activity
L	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 3

Chain	Residue
A	LYS1105
A	LEU1106
A	GLY1109
A	GLN1110
A	TYR1111

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG A 1

Chain	Residue
A	VAL1118
A	TRP1122
E	TYR1141

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 1

Chain	Residue
E	ASP1119
E	TRP1122
E	HOH283

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 2

Chain	Residue
E	ARG1137
E	TYR1141
G	PRO1070
G	LEU1073

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG E 1162

Chain	Residue
E	ASP1088
E	TYR1131
E	ASN1132
E	ARG1133
E	SER1136

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 2

Chain	Residue
H	TYR1139
L	ARG1133
L	THR1135

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVkspMdlstIkrkldtgq..Yqepwqyvddiwl.MfnNAwlY

Chain	Residue	Details
A	SER1072-TYR1131

---