Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3I2E

Crystal structure of human dimethylarginine dymethylaminohydrolase-1 (DDAH-1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000052biological_processcitrulline metabolic process
A0003073biological_processregulation of systemic arterial blood pressure
A0003824molecular_functioncatalytic activity
A0005829cellular_componentcytosol
A0006525biological_processarginine metabolic process
A0006527biological_processarginine catabolic process
A0007263biological_processnitric oxide mediated signal transduction
A0008285biological_processnegative regulation of cell population proliferation
A0016403molecular_functiondimethylargininase activity
A0016597molecular_functionamino acid binding
A0016787molecular_functionhydrolase activity
A0043116biological_processnegative regulation of vascular permeability
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045766biological_processpositive regulation of angiogenesis
A0046209biological_processnitric oxide metabolic process
A0046872molecular_functionmetal ion binding
A0070062cellular_componentextracellular exosome
A1900038biological_processnegative regulation of cellular response to hypoxia
B0000052biological_processcitrulline metabolic process
B0003073biological_processregulation of systemic arterial blood pressure
B0003824molecular_functioncatalytic activity
B0005829cellular_componentcytosol
B0006525biological_processarginine metabolic process
B0006527biological_processarginine catabolic process
B0007263biological_processnitric oxide mediated signal transduction
B0008285biological_processnegative regulation of cell population proliferation
B0016403molecular_functiondimethylargininase activity
B0016597molecular_functionamino acid binding
B0016787molecular_functionhydrolase activity
B0043116biological_processnegative regulation of vascular permeability
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0045766biological_processpositive regulation of angiogenesis
B0046209biological_processnitric oxide metabolic process
B0046872molecular_functionmetal ion binding
B0070062cellular_componentextracellular exosome
B1900038biological_processnegative regulation of cellular response to hypoxia
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000305|PubMed:19663506
ChainResidueDetails
AHIS173
BHIS173

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:19663506
ChainResidueDetails
ACYS274
BCYS274

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING:
ChainResidueDetails
ALEU30
BARG98
BARG145
BVAL268
AASP73
AGLU78
AARG98
AARG145
AVAL268
BLEU30
BASP73
BGLU78

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ACYS274
BCYS274

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:9874257, ECO:0007744|PubMed:19413330
ChainResidueDetails
AALA2
BALA2

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P56965
ChainResidueDetails
ACYS222
ACYS274
BCYS222
BCYS274

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1jdw
ChainResidueDetails
ACYS274
AASP127
AHIS173

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1jdw
ChainResidueDetails
BCYS274
BASP127
BHIS173

222415

PDB entries from 2024-07-10

PDB statisticsPDBj update infoContact PDBjnumon