Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3I2B

The crystal structure of human 6 Pyruvoyl Tetrahydrobiopterin Synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003874	molecular_function	6-pyruvoyltetrahydropterin synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0007417	biological_process	central nervous system development
A	0016829	molecular_function	lyase activity
A	0042802	molecular_function	identical protein binding
A	0046146	biological_process	tetrahydrobiopterin metabolic process
A	0046872	molecular_function	metal ion binding
B	0003874	molecular_function	6-pyruvoyltetrahydropterin synthase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006520	biological_process	amino acid metabolic process
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0007417	biological_process	central nervous system development
B	0016829	molecular_function	lyase activity
B	0042802	molecular_function	identical protein binding
B	0046146	biological_process	tetrahydrobiopterin metabolic process
B	0046872	molecular_function	metal ion binding
C	0003874	molecular_function	6-pyruvoyltetrahydropterin synthase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0007417	biological_process	central nervous system development
C	0016829	molecular_function	lyase activity
C	0042802	molecular_function	identical protein binding
C	0046146	biological_process	tetrahydrobiopterin metabolic process
C	0046872	molecular_function	metal ion binding
D	0003874	molecular_function	6-pyruvoyltetrahydropterin synthase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006520	biological_process	amino acid metabolic process
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0007417	biological_process	central nervous system development
D	0016829	molecular_function	lyase activity
D	0042802	molecular_function	identical protein binding
D	0046146	biological_process	tetrahydrobiopterin metabolic process
D	0046872	molecular_function	metal ion binding
E	0003874	molecular_function	6-pyruvoyltetrahydropterin synthase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0006520	biological_process	amino acid metabolic process
E	0006729	biological_process	tetrahydrobiopterin biosynthetic process
E	0007417	biological_process	central nervous system development
E	0016829	molecular_function	lyase activity
E	0042802	molecular_function	identical protein binding
E	0046146	biological_process	tetrahydrobiopterin metabolic process
E	0046872	molecular_function	metal ion binding
F	0003874	molecular_function	6-pyruvoyltetrahydropterin synthase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0006520	biological_process	amino acid metabolic process
F	0006729	biological_process	tetrahydrobiopterin biosynthetic process
F	0007417	biological_process	central nervous system development
F	0016829	molecular_function	lyase activity
F	0042802	molecular_function	identical protein binding
F	0046146	biological_process	tetrahydrobiopterin metabolic process
F	0046872	molecular_function	metal ion binding
G	0003874	molecular_function	6-pyruvoyltetrahydropterin synthase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0006520	biological_process	amino acid metabolic process
G	0006729	biological_process	tetrahydrobiopterin biosynthetic process
G	0007417	biological_process	central nervous system development
G	0016829	molecular_function	lyase activity
G	0042802	molecular_function	identical protein binding
G	0046146	biological_process	tetrahydrobiopterin metabolic process
G	0046872	molecular_function	metal ion binding
H	0003874	molecular_function	6-pyruvoyltetrahydropterin synthase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0006520	biological_process	amino acid metabolic process
H	0006729	biological_process	tetrahydrobiopterin biosynthetic process
H	0007417	biological_process	central nervous system development
H	0016829	molecular_function	lyase activity
H	0042802	molecular_function	identical protein binding
H	0046146	biological_process	tetrahydrobiopterin metabolic process
H	0046872	molecular_function	metal ion binding
I	0003874	molecular_function	6-pyruvoyltetrahydropterin synthase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005829	cellular_component	cytosol
I	0006520	biological_process	amino acid metabolic process
I	0006729	biological_process	tetrahydrobiopterin biosynthetic process
I	0007417	biological_process	central nervous system development
I	0016829	molecular_function	lyase activity
I	0042802	molecular_function	identical protein binding
I	0046146	biological_process	tetrahydrobiopterin metabolic process
I	0046872	molecular_function	metal ion binding
J	0003874	molecular_function	6-pyruvoyltetrahydropterin synthase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0006520	biological_process	amino acid metabolic process
J	0006729	biological_process	tetrahydrobiopterin biosynthetic process
J	0007417	biological_process	central nervous system development
J	0016829	molecular_function	lyase activity
J	0042802	molecular_function	identical protein binding
J	0046146	biological_process	tetrahydrobiopterin metabolic process
J	0046872	molecular_function	metal ion binding
K	0003874	molecular_function	6-pyruvoyltetrahydropterin synthase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005829	cellular_component	cytosol
K	0006520	biological_process	amino acid metabolic process
K	0006729	biological_process	tetrahydrobiopterin biosynthetic process
K	0007417	biological_process	central nervous system development
K	0016829	molecular_function	lyase activity
K	0042802	molecular_function	identical protein binding
K	0046146	biological_process	tetrahydrobiopterin metabolic process
K	0046872	molecular_function	metal ion binding
L	0003874	molecular_function	6-pyruvoyltetrahydropterin synthase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005829	cellular_component	cytosol
L	0006520	biological_process	amino acid metabolic process
L	0006729	biological_process	tetrahydrobiopterin biosynthetic process
L	0007417	biological_process	central nervous system development
L	0016829	molecular_function	lyase activity
L	0042802	molecular_function	identical protein binding
L	0046146	biological_process	tetrahydrobiopterin metabolic process
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1

Chain	Residue
A	ASP75
C	GLU35

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI A 146

Chain	Residue
A	HIS24
A	HIS49
A	HIS51
A	GLU134
A	HOH293

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 2

Chain	Residue
A	ASP116
A	TYR142

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI D 4

Chain	Residue
D	HIS24
D	HIS49
D	HIS51
D	GLU134
D	HOH154

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI E 146

Chain	Residue
E	HIS24
E	HIS49
E	HIS51
E	GLU134
E	HOH152
E	HOH277

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG B 1

Chain	Residue
A	GLU62
A	ASP64
B	GLU62
B	ASP64
B	VAL70

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI B 2

Chain	Residue
B	HIS24
B	HIS49
B	HIS51
B	GLU134
B	HOH275

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI C 3

Chain	Residue
C	HIS24
C	HIS49
C	HIS51
C	GLU134
C	HOH159
C	HOH270

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI F 146

Chain	Residue
F	HIS24
F	HIS49
F	HIS51
F	GLU134
F	HOH203
F	HOH295

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI G 146

Chain	Residue
G	HIS24
G	HIS49
G	HIS51
G	GLU134
G	HOH155

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI H 146

Chain	Residue
E	HOH196
H	HIS24
H	HIS49
H	HIS51
H	GLU134
H	HOH152

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI I 146

Chain	Residue
I	HIS24
I	HIS49
I	HIS51
I	GLU134
I	HOH152
I	HOH273

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI J 146

Chain	Residue
J	HIS24
J	HIS49
J	HIS51
J	GLU134
J	HOH157
J	HOH272

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI K 146

Chain	Residue
K	HIS24
K	HIS49
K	HIS51
K	GLU134
K	HOH153
K	HOH278

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG K 1

Chain	Residue
K	ASP116

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI L 146

Chain	Residue
L	HIS24
L	HIS49
L	HIS51
L	GLU134
L	HOH155

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VVSTteNvAVYIWDN

Chain	Residue	Details
A	VAL103-ASN117

site_id	PS00987
Number of Residues	11
Details	PTPS_1 6-pyruvoyl tetrahydropterin synthase signature 1. CNNpnGHGHNY

Chain	Residue	Details
A	CYS43-TYR53

site_id	PS00988
Number of Residues	8
Details	PTPS_2 6-pyruvoyl tetrahydropterin synthase signature 2. DHKNLDmD

Chain	Residue	Details
A	ASP89-ASP96

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10123","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU10124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10123","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"10531334","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9R1Z7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
A	CYS43
A	GLU134

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
J	CYS43
J	GLU134

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
K	CYS43
K	GLU134

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
L	CYS43
L	GLU134

site_id	CSA13
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
A	HIS90
A	ASP89

site_id	CSA14
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
D	HIS90
D	ASP89

site_id	CSA15
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
E	HIS90
E	ASP89

site_id	CSA16
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
B	HIS90
B	ASP89

site_id	CSA17
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
C	HIS90
C	ASP89

site_id	CSA18
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
F	HIS90
F	ASP89

site_id	CSA19
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
G	HIS90
G	ASP89

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
D	CYS43
D	GLU134

site_id	CSA20
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
H	HIS90
H	ASP89

site_id	CSA21
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
I	HIS90
I	ASP89

site_id	CSA22
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
J	HIS90
J	ASP89

site_id	CSA23
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
K	HIS90
K	ASP89

site_id	CSA24
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
L	HIS90
L	ASP89

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
E	CYS43
E	GLU134

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
B	CYS43
B	GLU134

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
C	CYS43
C	GLU134

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
F	CYS43
F	GLU134

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
G	CYS43
G	GLU134

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
H	CYS43
H	GLU134

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1b66

Chain	Residue	Details
I	CYS43
I	GLU134

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)