3HZD

Crystal structure of bothropstoxin-I (BthTX-I), a PLA2 homologue from Bothrops jararacussu venom

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004623	molecular_function	phospholipase A2 activity
A	0005509	molecular_function	calcium ion binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0006644	biological_process	phospholipid metabolic process
A	0008201	molecular_function	heparin binding
A	0016042	biological_process	lipid catabolic process
A	0035821	biological_process	modulation of process of another organism
A	0042130	biological_process	negative regulation of T cell proliferation
A	0042742	biological_process	defense response to bacterium
A	0047498	molecular_function	calcium-dependent phospholipase A2 activity
A	0050482	biological_process	arachidonic acid secretion
A	0090729	molecular_function	toxin activity
B	0004623	molecular_function	phospholipase A2 activity
B	0005509	molecular_function	calcium ion binding
B	0005543	molecular_function	phospholipid binding
B	0005576	cellular_component	extracellular region
B	0006644	biological_process	phospholipid metabolic process
B	0008201	molecular_function	heparin binding
B	0016042	biological_process	lipid catabolic process
B	0035821	biological_process	modulation of process of another organism
B	0042130	biological_process	negative regulation of T cell proliferation
B	0042742	biological_process	defense response to bacterium
B	0047498	molecular_function	calcium-dependent phospholipase A2 activity
B	0050482	biological_process	arachidonic acid secretion
B	0090729	molecular_function	toxin activity

Functional Information from PDB Data

Functional Information from PROSITE/UniProt

site_id	PS00118
Number of Residues	8
Details	PA2_HIS Phospholipase A2 histidine active site. CCYvHKcC

Chain	Residue	Details
A	CYS44-CYS51

site_id	PS00119
Number of Residues	11
Details	PA2_ASP Phospholipase A2 aspartic acid active site. LCECDKAVaIC

Chain	Residue	Details
A	LEU95-CYS105

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Important residue of the cationic membrane-docking site (MDoS) => ECO:0000250\|UniProtKB:I6L8L6

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Hydrophobic membrane-disruption site (MDiS) => ECO:0000250\|UniProtKB:I6L8L6

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Cationic membrane-docking site (MDoS) => ECO:0000250\|UniProtKB:I6L8L6

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29