3HXZ

Crystal Structure of catalytic fragment of E. coli AlaRS G237A in complex with AlaSA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0004813	molecular_function	alanine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006419	biological_process	alanyl-tRNA aminoacylation
B	0000166	molecular_function	nucleotide binding
B	0003676	molecular_function	nucleic acid binding
B	0004813	molecular_function	alanine-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006419	biological_process	alanyl-tRNA aminoacylation
C	0000166	molecular_function	nucleotide binding
C	0003676	molecular_function	nucleic acid binding
C	0004813	molecular_function	alanine-tRNA ligase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006419	biological_process	alanyl-tRNA aminoacylation
D	0000166	molecular_function	nucleotide binding
D	0003676	molecular_function	nucleic acid binding
D	0004813	molecular_function	alanine-tRNA ligase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006419	biological_process	alanyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE A5A A 442

Chain	Residue
A	ARG69
A	ILE210
A	ASN212
A	VAL214
A	ASP235
A	ALA237
A	GLY239
A	ARG242
A	HOH456
A	HOH463
A	HOH465
A	ASP76
A	HOH554
A	HOH918
A	ARG85
A	HIS86
A	HIS87
A	PHE90
A	MET92
A	TRP170
A	GLU209

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE EPE A 443

Chain	Residue
A	LYS124
A	GLU125
A	ARG152
A	HOH824
A	HOH1187
A	HOH1481
A	HOH1640
C	SER25
C	GLU346
C	ASP347
C	HOH1109

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE EPE A 444

Chain	Residue
A	SER25
A	ARG66
A	GLU346
A	ASP347
A	HOH848
A	HOH908
A	HOH1236
A	HOH2080
A	HOH2115
D	GLU125
D	ARG152

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE HED A 445

Chain	Residue
A	LYS18
A	ARG60
A	ASP100
A	TYR101
A	ASP105
A	PHE109
A	HOH764
C	ARG396
C	ARG434

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HED A 446

Chain	Residue
A	PRO34
A	ASN304
A	HOH2378
A	HOH2402

---

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE A5A B 442

Chain	Residue
B	ARG69
B	ASP76
B	ARG85
B	HIS86
B	HIS87
B	PHE90
B	MET92
B	TRP170
B	GLU209
B	ILE210
B	ASN212
B	ASP235
B	ALA237
B	GLY239
B	ARG242
B	HOH459
B	HOH467
B	HOH527
B	HOH598
B	HOH931

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EPE B 443

Chain	Residue
B	GLU125
B	ARG152
B	HOH897
B	HOH1139
B	HOH1589
B	HOH1829
D	SER25
D	GLU346
D	ASP347
D	HOH1137

---

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE EPE B 444

Chain	Residue
B	SER25
B	ARG66
B	GLU346
B	ASP347
B	HOH1118
B	HOH1144
B	HOH1201
B	HOH1821
B	HOH2418
C	LYS124
C	GLU125
C	ARG152

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE HED B 445

Chain	Residue
B	ARG60
B	PHE109
B	HOH989
B	HOH1287
B	HOH2204
D	ARG434
B	LYS18

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE HED B 446

Chain	Residue
B	PRO34
B	ARG305
B	HOH1485
B	HOH1503
B	HOH2059

---

site_id	BC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE A5A C 442

Chain	Residue
C	ARG69
C	ASP76
C	ARG85
C	HIS86
C	HIS87
C	PHE90
C	MET92
C	TRP170
C	GLU209
C	ILE210
C	ASN212
C	VAL214
C	ASP235
C	ALA237
C	GLY239
C	ARG242
C	HOH446
C	HOH456
C	HOH460
C	HOH511
C	HOH1127

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE HED C 443

Chain	Residue
A	ARG434
C	LYS18
C	ARG60
C	PHE109
C	HOH1173
C	HOH1486
C	HOH1783

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE HED C 444

Chain	Residue
C	PRO34
C	ASN304
C	ARG305
C	HOH1470
C	HOH2205

---

site_id	BC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE A5A D 442

Chain	Residue
D	ARG69
D	ASP76
D	ARG85
D	HIS86
D	HIS87
D	PHE90
D	MET92
D	TRP170
D	GLU183
D	GLU209
D	ILE210
D	ASN212
D	VAL214
D	ASP235
D	ALA237
D	GLY239
D	ARG242
D	HOH446
D	HOH453
D	HOH555
D	HOH593
D	HOH1085

---

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE HED D 443

Chain	Residue
B	ARG396
B	ARG434
D	LYS18
D	ARG60
D	ASP100
D	PHE109
D	HOH687
D	HOH1879

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HED D 444

Chain	Residue
D	PRO34
D	HOH2361

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842

Chain	Residue	Details
A	LYS73
B	LYS73
C	LYS73
D	LYS73

---