3HXG

Crystal structure of Schistsome eIF4E complexed with m7GpppA and 4E-BP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0005737	cellular_component	cytoplasm
A	0006413	biological_process	translational initiation
C	0008190	molecular_function	eukaryotic initiation factor 4E binding
C	0045947	biological_process	negative regulation of translational initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GTA A 1

Chain	Residue
A	HOH5
A	LYS88
A	TRP89
A	GLU90
A	GLN141
A	ARG143
A	LYS148
A	ARG192
A	HOH210
A	HOH211
A	HOH220
A	HOH8
A	HOH222
A	HOH245
A	HOH261
A	HOH276
A	HOH277
A	HOH285
A	GLU21
A	PHE22
A	PHE35
A	PHE37
A	TRP43
A	GLY75
A	ASP84

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Functional Information from PROSITE/UniProt

site_id	PS00813
Number of Residues	24
Details	IF4E Eukaryotic initiation factor 4E signature. DLymFKsdImPkWEDpknenGGRW

Chain	Residue	Details
A	ASP77-TRP100

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Motif: {"description":"YXXXXLphi motif","evidences":[{"source":"UniProtKB","id":"P70445","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22578813","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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