3HWR
Crystal structure of PanE/ApbA family ketopantoate reductase (YP_299159.1) from Ralstonia eutropha JMP134 at 2.15 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008677 | molecular_function | 2-dehydropantoate 2-reductase activity |
| A | 0015940 | biological_process | pantothenate biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008677 | molecular_function | 2-dehydropantoate 2-reductase activity |
| B | 0015940 | biological_process | pantothenate biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NDP A 300 |
| Chain | Residue |
| A | MSE6 |
| A | LEU100 |
| A | GLN101 |
| A | ASN102 |
| A | VAL123 |
| A | VAL125 |
| A | ALA126 |
| A | THR127 |
| A | GLU260 |
| A | HOH312 |
| A | HOH400 |
| A | GLY7 |
| A | GLY9 |
| A | ALA10 |
| A | VAL11 |
| A | ILE29 |
| A | ARG31 |
| A | CYS74 |
| A | ASP79 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BCN A 301 |
| Chain | Residue |
| A | LEU181 |
| A | ASN182 |
| A | TYR185 |
| A | ASN186 |
| A | TYR196 |
| A | GLN245 |
| A | SER246 |
| A | SER247 |
| A | SER248 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MRD A 302 |
| Chain | Residue |
| A | TYR124 |
| A | LYS178 |
| A | LEU181 |
| A | ALA234 |
| A | HOH363 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NDP B 300 |
| Chain | Residue |
| B | MSE6 |
| B | GLY7 |
| B | GLY9 |
| B | ALA10 |
| B | VAL11 |
| B | ARG31 |
| B | CYS74 |
| B | VAL75 |
| B | LYS76 |
| B | ASP79 |
| B | LEU100 |
| B | GLN101 |
| B | ASN102 |
| B | VAL125 |
| B | ALA126 |
| B | THR127 |
| B | GLU260 |
| B | HOH313 |
| B | HOH333 |
| B | HOH349 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BCN B 301 |
| Chain | Residue |
| B | LEU181 |
| B | ASN182 |
| B | TYR185 |
| B | ASN186 |
| B | TYR196 |
| B | GLN245 |
| B | SER247 |
| B | SER248 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MRD B 302 |
| Chain | Residue |
| B | TYR124 |
| B | ALA177 |
| B | LYS178 |
