3HOT

Crystal structure of the Mos1 mariner paired end complex with Mn

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
A	0000729	biological_process	DNA double-strand break processing
A	0000793	cellular_component	condensed chromosome
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0004519	molecular_function	endonuclease activity
A	0005634	cellular_component	nucleus
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006310	biological_process	DNA recombination
A	0006338	biological_process	chromatin remodeling
A	0015074	biological_process	DNA integration
A	0031297	biological_process	replication fork processing
A	0035861	cellular_component	site of double-strand break
A	0042800	molecular_function	histone H3K4 methyltransferase activity
A	0044547	molecular_function	DNA topoisomerase binding
A	0044774	biological_process	mitotic DNA integrity checkpoint signaling
A	0046872	molecular_function	metal ion binding
A	0046975	molecular_function	histone H3K36 methyltransferase activity
B	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
B	0000729	biological_process	DNA double-strand break processing
B	0000793	cellular_component	condensed chromosome
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0004519	molecular_function	endonuclease activity
B	0005634	cellular_component	nucleus
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0006310	biological_process	DNA recombination
B	0006338	biological_process	chromatin remodeling
B	0015074	biological_process	DNA integration
B	0031297	biological_process	replication fork processing
B	0035861	cellular_component	site of double-strand break
B	0042800	molecular_function	histone H3K4 methyltransferase activity
B	0044547	molecular_function	DNA topoisomerase binding
B	0044774	biological_process	mitotic DNA integrity checkpoint signaling
B	0046872	molecular_function	metal ion binding
B	0046975	molecular_function	histone H3K36 methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MN A 1001

Chain	Residue
A	ASP156
A	ASP249

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 346

Chain	Residue
B	ARG71
F	DT45

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 1

Chain	Residue
A	ARG71
D	DT45

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	104
Details	DNA_BIND: H-T-H motif

Chain	Residue	Details
A	THR24-SER55
A	GLN89-MET110
B	THR24-SER55
B	GLN89-MET110

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
A	ASP156
A	ASP249
A	ASP284
B	ASP156
B	ASP249
B	ASP284

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site_id	SWS_FT_FI3
Number of Residues	8
Details	SITE: Important for base-specific DNA-binding

Chain	Residue	Details
A	ARG48
A	GLN100
A	ARG118
A	HIS293
B	ARG48
B	GLN100
B	ARG118
B	HIS293

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Important for target DNA recognition and for strand transfer activity

Chain	Residue	Details
A	ARG186
B	ARG186

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