3HN3
Human beta-glucuronidase at 1.7 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| E | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| E | 0005975 | biological_process | carbohydrate metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00608 |
| Number of Residues | 15 |
| Details | GLYCOSYL_HYDROL_F2_2 Glycosyl hydrolases family 2 acid/base catalyst. DKNHPAVVMWSva.NE |
| Chain | Residue | Details |
| A | ASP437-GLU451 |
| site_id | PS00719 |
| Number of Residues | 26 |
| Details | GLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NaFRTSHYPyaeeVMqmcDryGIVVI |
| Chain | Residue | Details |
| A | ASN379-ILE404 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor |
| Chain | Residue | Details |
| A | GLU451 | |
| B | GLU451 | |
| D | GLU451 | |
| E | GLU451 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN173 | |
| A | ASN631 | |
| B | ASN173 | |
| B | ASN631 | |
| D | ASN173 | |
| D | ASN631 | |
| E | ASN173 | |
| E | ASN631 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN272 | |
| B | ASN272 | |
| D | ASN272 | |
| E | ASN272 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine |
| Chain | Residue | Details |
| A | ASN420 | |
| B | ASN420 | |
| D | ASN420 | |
| E | ASN420 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 423 |
| Chain | Residue | Details |
| A | ASP207 | electrostatic stabiliser |
| A | GLU451 | proton shuttle (general acid/base) |
| A | TYR504 | electrostatic stabiliser |
| A | GLU540 | covalent catalysis |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 423 |
| Chain | Residue | Details |
| B | ASP207 | electrostatic stabiliser |
| B | GLU451 | proton shuttle (general acid/base) |
| B | TYR504 | electrostatic stabiliser |
| B | GLU540 | covalent catalysis |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 423 |
| Chain | Residue | Details |
| D | ASP207 | electrostatic stabiliser |
| D | GLU451 | proton shuttle (general acid/base) |
| D | TYR504 | electrostatic stabiliser |
| D | GLU540 | covalent catalysis |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 423 |
| Chain | Residue | Details |
| E | ASP207 | electrostatic stabiliser |
| E | GLU451 | proton shuttle (general acid/base) |
| E | TYR504 | electrostatic stabiliser |
| E | GLU540 | covalent catalysis |
