3HM3

The Structure and conformation of Lys-63 linked tetra-ubiquitin

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 600

Chain	Residue
A	GLU64
C	HIS68
C	HOH121

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 700

Chain	Residue
A	GLU18
A	GLU18
A	ASP21
A	HOH88

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 400

Chain	Residue
B	ASN25
B	LYS29
B	HOH91
B	GLU18
B	ASP21

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C 100

Chain	Residue
A	HIS68
A	HOH92
C	GLU64

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 200

Chain	Residue
C	GLU18
C	ASP21
C	LYS29
C	HOH85

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 900

Chain	Residue
D	GLU18
D	GLU18
D	ASP21
D	HOH89

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
A	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
B	ARG54
B	ARG72
C	ARG54
C	ARG72
D	ARG54
D	ARG72
A	ARG54
A	ARG72

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Essential for function

Chain	Residue	Details
B	HIS68
C	HIS68
D	HIS68
A	HIS68

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291

Chain	Residue	Details
B	SER65
C	SER65
D	SER65
A	SER65

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457

Chain	Residue	Details
D	THR66
B	THR66
C	THR66
A	THR66

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
A	GLY76
B	GLY76
C	GLY76
D	GLY76

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603

Chain	Residue	Details
A	LYS6
C	LYS6
B	LYS6
D	LYS6

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
A	GLY76
B	GLY76
C	GLY76
D	GLY76

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144

Chain	Residue	Details
C	LYS11
C	LYS48
D	LYS11
D	LYS48
A	LYS11
A	LYS48
B	LYS11
B	LYS48

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860

Chain	Residue	Details
A	LYS27
B	LYS27
C	LYS27
D	LYS27

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127

Chain	Residue	Details
A	LYS29
B	LYS29
C	LYS29
D	LYS29

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577

Chain	Residue	Details
A	LYS33
B	LYS33
C	LYS33
D	LYS33

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106

Chain	Residue	Details
A	LYS63
B	LYS63
C	LYS63
D	LYS63

---