3HL8
Crystal structure of exonuclease I in complex with inhibitor BCBP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0003677 | molecular_function | DNA binding |
A | 0003697 | molecular_function | single-stranded DNA binding |
A | 0004527 | molecular_function | exonuclease activity |
A | 0004529 | molecular_function | DNA exonuclease activity |
A | 0005515 | molecular_function | protein binding |
A | 0006274 | biological_process | DNA replication termination |
A | 0006281 | biological_process | DNA repair |
A | 0006308 | biological_process | DNA catabolic process |
A | 0008310 | molecular_function | single-stranded DNA 3'-5' DNA exonuclease activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0051575 | molecular_function | 5'-deoxyribose-5-phosphate lyase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 500 |
Chain | Residue |
A | ASP15 |
A | HOH514 |
A | HOH519 |
A | HOH520 |
A | HOH521 |
A | HOH522 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE BBP A 501 |
Chain | Residue |
A | ARG327 |
A | LEU331 |
A | HOH571 |
A | HOH855 |
A | TRP245 |
A | LEU264 |
A | ASN313 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS A 502 |
Chain | Residue |
A | TYR145 |
A | ALA238 |
A | TRP239 |
A | ARG322 |
A | LEU323 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS A 503 |
Chain | Residue |
A | ARG327 |
A | GLN453 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 504 |
Chain | Residue |
A | GLU17 |
A | THR18 |
A | GLY20 |
A | THR67 |
A | HOH711 |
A | HOH969 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 505 |
Chain | Residue |
A | ARG203 |
A | LEU204 |
A | TYR207 |
A | HOH548 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 506 |
Chain | Residue |
A | ASP122 |
A | ARG377 |
A | MET380 |
A | HOH635 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11101894, ECO:0000269|PubMed:18219121, ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540 |
Chain | Residue | Details |
A | ASP15 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18219121 |
Chain | Residue | Details |
A | GLU17 | |
A | ARG165 | |
A | ASP186 |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | SITE: Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 |
Chain | Residue | Details |
A | THR18 | |
A | PHE371 | |
A | ILE66 | |
A | ARG113 | |
A | TYR124 | |
A | TRP128 | |
A | ARG142 | |
A | LYS214 | |
A | TYR284 | |
A | TYR368 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | SITE: Important for interaction with ssb => ECO:0000269|PubMed:18591666 |
Chain | Residue | Details |
A | ARG148 | |
A | TYR207 | |
A | GLN311 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | SITE: Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC |
Chain | Residue | Details |
A | PHE164 | |
A | ASN257 | |
A | ASN304 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | SITE: Important for activity => ECO:0000269|PubMed:23609540 |
Chain | Residue | Details |
A | HIS181 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | SITE: Important for interaction with ssb => ECO:0000305|PubMed:20018747 |
Chain | Residue | Details |
A | ARG338 |