3HL8

Crystal structure of exonuclease I in complex with inhibitor BCBP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000175	molecular_function	3'-5'-RNA exonuclease activity
A	0000287	molecular_function	magnesium ion binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0004529	molecular_function	DNA exonuclease activity
A	0005515	molecular_function	protein binding
A	0006259	biological_process	DNA metabolic process
A	0006274	biological_process	DNA replication termination
A	0006281	biological_process	DNA repair
A	0006308	biological_process	DNA catabolic process
A	0006974	biological_process	DNA damage response
A	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 500

Chain	Residue
A	ASP15
A	HOH514
A	HOH519
A	HOH520
A	HOH521
A	HOH522

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BBP A 501

Chain	Residue
A	ARG327
A	LEU331
A	HOH571
A	HOH855
A	TRP245
A	LEU264
A	ASN313

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 502

Chain	Residue
A	TYR145
A	ALA238
A	TRP239
A	ARG322
A	LEU323

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS A 503

Chain	Residue
A	ARG327
A	GLN453

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 504

Chain	Residue
A	GLU17
A	THR18
A	GLY20
A	THR67
A	HOH711
A	HOH969

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 505

Chain	Residue
A	ARG203
A	LEU204
A	TYR207
A	HOH548

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 506

Chain	Residue
A	ASP122
A	ARG377
A	MET380
A	HOH635

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11101894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18219121","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18591666","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20018747","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23609540","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18219121","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Site: {"description":"Interaction with single-stranded DNA","evidences":[{"source":"PubMed","id":"23609540","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Site: {"description":"Important for interaction with ssb","evidences":[{"source":"PubMed","id":"18591666","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Site: {"description":"Interaction with single-stranded DNA","evidences":[{"source":"PubMed","id":"23609540","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HCC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Important for interaction with ssb","evidences":[{"source":"PubMed","id":"20018747","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---