English 日本語简体中文繁體中文 한국어

✖

Menu

RCSB PDB PDBe BMRB Adv. Search Search help

Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3HKW

HCV NS5B genotype 1a in complex with 1,5 benzodiazepine inhibitor 6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-dependent RNA polymerase activity
B	0039694	biological_process	viral RNA genome replication
C	0003723	molecular_function	RNA binding
C	0003968	molecular_function	RNA-dependent RNA polymerase activity
C	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE IX6 A 579

Chain	Residue
A	PHE193
A	TYR448
A	GLY449
A	SER556
A	HOH821
A	HOH880
A	CYS366
A	SER367
A	ARG386
A	ASN411
A	MET414
A	PHE415
A	GLU446
A	ILE447

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 580

Chain	Residue
A	ASN24
A	ARG436
A	HOH801
A	HOH1164
A	HOH1170
C	LYS209
C	ARG380
C	TYR382
C	HOH1409

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 581

Chain	Residue
A	LYS209
A	ARG380
A	TYR382
A	HOH605
A	HOH890
B	ASN24
B	ARG436
B	HOH672

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 582

Chain	Residue
A	ARG32
A	HIS33
A	GLU237
A	GLN241
A	LYS254
A	HOH726
A	HOH955
A	HOH1554

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 583

Chain	Residue
A	ARG505
A	ARG531
A	THR532
A	HOH640

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 584

Chain	Residue
A	GLU440
A	GLY516
A	ARG517
A	HOH924
A	HOH1515

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 585

Chain	Residue
A	ARG48
A	LYS51
A	ARG222
A	CYS223
A	HOH947

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 586

Chain	Residue
A	ASN28
A	ARG32
A	HIS34
A	VAL251
A	HOH609
A	HOH661
A	HOH727
A	HOH1159

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 587

Chain	Residue
A	SER29
A	ASP244
A	ARG250
A	PRO495
A	ARG503
A	HOH779
A	HOH836
A	HOH1119

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 588

Chain	Residue
A	HIS475
A	SER476
A	HOH845

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 589

Chain	Residue
A	GLN58
A	LEU60
A	SER231
A	HOH883
A	HOH891

site_id	BC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE IX6 B 579

Chain	Residue
B	PHE193
B	ARG200
B	CYS366
B	SER367
B	SER368
B	ARG386
B	ASN411
B	MET414
B	PHE415
B	GLU446
B	ILE447
B	TYR448
B	GLY449
B	SER556
B	HOH773
B	HOH897
B	HOH900

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 580

Chain	Residue
B	HOH846
B	HOH1181
B	HOH1212
B	HOH1478
B	ARG32
B	HIS33
B	GLU237
B	GLN241
B	LYS254

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 581

Chain	Residue
B	ARG48
B	LYS51
B	ARG222
B	CYS223
B	HOH1383

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 582

Chain	Residue
A	HIS374
A	ARG380
B	HIS402
B	GLN438
B	GOL585
B	HOH738

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 583

Chain	Residue
B	GLU440
B	GLY516
B	ARG517
B	HOH803
B	HOH1506

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 584

Chain	Residue
B	ARG505
B	VAL530
B	ARG531
B	THR532

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 585

Chain	Residue
B	GLU398
B	ASN406
B	TRP408
B	VAL432
B	ARG436
B	GLN438
B	SO4582
B	HOH780

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 586

Chain	Residue
B	SER29
B	ASP244
B	ARG250
B	PRO495
B	ARG503
B	HOH699
B	HOH912

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 587

Chain	Residue
B	HIS475
B	SER476
B	HOH719

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 588

Chain	Residue
B	SER39
B	ASN142
B	GLU143
B	VAL144
B	TRP397
B	HOH1060

site_id	CC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE IX6 C 579

Chain	Residue
C	PHE193
C	CYS366
C	SER367
C	SER368
C	ARG386
C	ASN411
C	MET414
C	PHE415
C	GLU446
C	ILE447
C	TYR448
C	GLY449
C	SER556
C	HOH720
C	HOH884
C	HOH945

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 580

Chain	Residue
C	ARG32
C	HIS33
C	LYS69
C	LYS72

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 581

Chain	Residue
C	ARG48
C	LYS51
C	ARG222
C	CYS223
C	HOH973

site_id	CC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 582

Chain	Residue
A	HIS402
A	GLN438
A	HOH838
A	HOH892
A	HOH979
A	HOH1125
C	HIS374
C	ARG380

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 583

Chain	Residue
C	ARG505
C	VAL530
C	ARG531
C	THR532

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 584

Chain	Residue
C	SER431
C	SER506
C	VAL507
C	LYS510
C	HOH683

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 585

Chain	Residue
C	GLU440
C	LEU457
C	GLY516
C	ARG517
C	HOH696

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P26663

Chain	Residue	Details
A	ASP220
A	ASP318
A	ASP319
B	ASP220
B	ASP318
B	ASP319
C	ASP220
C	ASP318
C	ASP319

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine; by host => ECO:0000250\|UniProtKB:P26662

Chain	Residue	Details
A	SER29
A	SER42
B	SER29
B	SER42
C	SER29
C	SER42

222926

PDB entries from 2024-07-24

PDB statistics

PDBj update info

Contact PDBj

numon