3HJU

Crystal structure of human monoglyceride lipase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
A	0005515	molecular_function	protein binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006954	biological_process	inflammatory response
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0019369	biological_process	arachidonate metabolic process
A	0019433	biological_process	triglyceride catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0046464	biological_process	acylglycerol catabolic process
A	0047372	molecular_function	monoacylglycerol lipase activity
A	0050727	biological_process	regulation of inflammatory response
A	0051930	biological_process	regulation of sensory perception of pain
A	0052651	biological_process	monoacylglycerol catabolic process
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	2000124	biological_process	regulation of endocannabinoid signaling pathway
B	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
B	0005515	molecular_function	protein binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006954	biological_process	inflammatory response
B	0009966	biological_process	regulation of signal transduction
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0019369	biological_process	arachidonate metabolic process
B	0019433	biological_process	triglyceride catabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0046464	biological_process	acylglycerol catabolic process
B	0047372	molecular_function	monoacylglycerol lipase activity
B	0050727	biological_process	regulation of inflammatory response
B	0051930	biological_process	regulation of sensory perception of pain
B	0052651	biological_process	monoacylglycerol catabolic process
B	0052689	molecular_function	carboxylic ester hydrolase activity
B	2000124	biological_process	regulation of endocannabinoid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 417

Chain	Residue
A	ALA51
A	GLU53
A	ARG57
A	HIS121
A	TYR194
A	VAL270

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 410

Chain	Residue
B	HIS121
B	VAL270
B	GLY50
B	ALA51
B	GLU53

---

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VFLLGHSMGG

Chain	Residue	Details
A	VAL116-GLY125

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"19957260","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19957260","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O35678","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"O35678","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1c4x

Chain	Residue	Details
A	HIS269
A	SER122
A	ASP239

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1c4x

Chain	Residue	Details
B	HIS269
B	SER122
B	ASP239

---