3HIK
Structure of human Plk1-PBD in complex with PLHSpT
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 2 |
| Chain | Residue |
| A | HOH114 |
| A | THR513 |
| A | TRP514 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 3 |
| Chain | Residue |
| A | HOH64 |
| A | TYR421 |
| A | ASN437 |
| A | ASP438 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 6 |
| Chain | Residue |
| A | GLU460 |
| A | PHE535 |
| A | HIS538 |
| B | PRO1 |
| B | HIS3 |
| B | TPO5 |
| B | HOH7 |
| B | HOH115 |
| A | GLY458 |
| A | THR459 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | Domain: {"description":"POLO box 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 82 |
| Details | Domain: {"description":"POLO box 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Region: {"description":"Linker"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Region: {"description":"Important for interaction with phosphorylated proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23455478","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
