3HH2
Crystal structure of the myostatin:follistatin 288 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0008083 | molecular_function | growth factor activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0008083 | molecular_function | growth factor activity |
| C | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| C | 0002244 | biological_process | hematopoietic progenitor cell differentiation |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005634 | cellular_component | nucleus |
| C | 0005730 | cellular_component | nucleolus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0030154 | biological_process | cell differentiation |
| C | 0030510 | biological_process | regulation of BMP signaling pathway |
| C | 0032926 | biological_process | negative regulation of activin receptor signaling pathway |
| C | 0038102 | molecular_function | activin receptor antagonist activity |
| C | 0043395 | molecular_function | heparan sulfate proteoglycan binding |
| C | 0048185 | molecular_function | activin binding |
| C | 0051798 | biological_process | positive regulation of hair follicle development |
| C | 0071363 | biological_process | cellular response to growth factor stimulus |
| D | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| D | 0002244 | biological_process | hematopoietic progenitor cell differentiation |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005634 | cellular_component | nucleus |
| D | 0005730 | cellular_component | nucleolus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0030154 | biological_process | cell differentiation |
| D | 0030510 | biological_process | regulation of BMP signaling pathway |
| D | 0032926 | biological_process | negative regulation of activin receptor signaling pathway |
| D | 0038102 | molecular_function | activin receptor antagonist activity |
| D | 0043395 | molecular_function | heparan sulfate proteoglycan binding |
| D | 0048185 | molecular_function | activin binding |
| D | 0051798 | biological_process | positive regulation of hair follicle development |
| D | 0071363 | biological_process | cellular response to growth factor stimulus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 110 |
| Chain | Residue |
| A | GLU12 |
| A | SER13 |
| A | ARG14 |
| C | PRO101 |
| C | ARG134 |
| D | TYR17 |
| D | LYS18 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 110 |
| Chain | Residue |
| C | ARG192 |
| D | THR45 |
| D | LYS48 |
| B | ASP30 |
| B | TRP31 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 C 289 |
| Chain | Residue |
| C | VAL142 |
| C | CYS144 |
| C | THR149 |
| C | CYS150 |
| C | LYS232 |
| C | SER257 |
| C | ASN259 |
| C | LYS282 |
| C | HOH411 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CIT C 290 |
| Chain | Residue |
| B | PHE2 |
| C | ARG6 |
| C | ALA8 |
| C | LYS9 |
| C | GLN14 |
| C | HOH407 |
| C | HOH409 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CIT C 291 |
| Chain | Residue |
| A | GLY28 |
| A | ASP30 |
| A | TRP31 |
| C | ASN44 |
| C | THR45 |
| C | LYS48 |
| D | ARG192 |
Functional Information from PROSITE/UniProt
| site_id | PS00250 |
| Number of Residues | 16 |
| Details | TGF_BETA_1 TGF-beta family signature. IiaPkrYkanyCsGeC |
| Chain | Residue | Details |
| A | ILE32-CYS47 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 146 |
| Details | Domain: {"description":"TB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00697","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 23 |
| Details | Domain: {"description":"Follistatin-like 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 54 |
| Details | Domain: {"description":"Kazal-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00798","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 46 |
| Details | Domain: {"description":"Follistatin-like 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 48 |
| Details | Domain: {"description":"Follistatin-like 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
