3HGX
Crystal Structure of Pseudomonas aeruginosa Isochorismate-Pyruvate Lyase K42A mutant in complex with salicylate and pyruvate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004106 | molecular_function | chorismate mutase activity |
| A | 0009697 | biological_process | salicylic acid biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016835 | molecular_function | carbon-oxygen lyase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0042864 | biological_process | pyochelin biosynthetic process |
| A | 0043904 | molecular_function | isochorismate pyruvate lyase activity |
| A | 0046417 | biological_process | chorismate metabolic process |
| B | 0004106 | molecular_function | chorismate mutase activity |
| B | 0009697 | biological_process | salicylic acid biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016835 | molecular_function | carbon-oxygen lyase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0042864 | biological_process | pyochelin biosynthetic process |
| B | 0043904 | molecular_function | isochorismate pyruvate lyase activity |
| B | 0046417 | biological_process | chorismate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SAL A 101 |
| Chain | Residue |
| A | ARG31 |
| B | HOH107 |
| A | VAL35 |
| A | ILE48 |
| A | PRO49 |
| A | MET57 |
| A | TYR86 |
| A | ILE87 |
| A | GLN90 |
| B | PYR102 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PYR B 102 |
| Chain | Residue |
| A | ALA38 |
| A | ARG53 |
| A | GLN90 |
| B | ARG14 |
| B | HOH107 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYR A 103 |
| Chain | Residue |
| A | ARG14 |
| A | ILE17 |
| B | ALA38 |
| B | ARG53 |
| B | GLN90 |
| B | SAL104 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SAL B 104 |
| Chain | Residue |
| A | PYR103 |
| B | ARG31 |
| B | VAL35 |
| B | ILE48 |
| B | PRO49 |
| B | MET57 |
| B | TYR86 |
| B | ILE87 |
| B | GLN90 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16914555, ECO:0000269|PubMed:21751784 |
| Chain | Residue | Details |
| A | ARG14 | |
| A | ALA42 | |
| B | ARG14 | |
| B | ALA42 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16914555, ECO:0000269|PubMed:19432488, ECO:0000269|PubMed:21751784 |
| Chain | Residue | Details |
| A | ARG31 | |
| A | GLN90 | |
| B | ARG31 | |
| B | GLN90 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| A | ARG31 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| B | ARG31 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| A | ARG14 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| B | ARG14 |
