3HFA

Crystal Structure of Mycobacterium Tuberculosis Proteasome open-gate mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000502	cellular_component	proteasome complex
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005515	molecular_function	protein binding
1	0005737	cellular_component	cytoplasm
1	0005839	cellular_component	proteasome core complex
1	0005886	cellular_component	plasma membrane
1	0009274	cellular_component	peptidoglycan-based cell wall
1	0010498	biological_process	proteasomal protein catabolic process
1	0019773	cellular_component	proteasome core complex, alpha-subunit complex
1	0019941	biological_process	modification-dependent protein catabolic process
1	0030682	biological_process	symbiont-mediated perturbation of host defenses
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
1	0051603	biological_process	proteolysis involved in protein catabolic process
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005839	cellular_component	proteasome core complex
2	0010498	biological_process	proteasomal protein catabolic process
2	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0010498	biological_process	proteasomal protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0019941	biological_process	modification-dependent protein catabolic process
A	0030682	biological_process	symbiont-mediated perturbation of host defenses
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0004175	molecular_function	endopeptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0005886	cellular_component	plasma membrane
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0019941	biological_process	modification-dependent protein catabolic process
B	0030682	biological_process	symbiont-mediated perturbation of host defenses
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005839	cellular_component	proteasome core complex
C	0010498	biological_process	proteasomal protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0004175	molecular_function	endopeptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0005886	cellular_component	plasma membrane
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0019941	biological_process	modification-dependent protein catabolic process
D	0030682	biological_process	symbiont-mediated perturbation of host defenses
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005839	cellular_component	proteasome core complex
E	0010498	biological_process	proteasomal protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0005886	cellular_component	plasma membrane
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0019941	biological_process	modification-dependent protein catabolic process
F	0030682	biological_process	symbiont-mediated perturbation of host defenses
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0004298	molecular_function	threonine-type endopeptidase activity
G	0005839	cellular_component	proteasome core complex
G	0010498	biological_process	proteasomal protein catabolic process
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0010498	biological_process	proteasomal protein catabolic process
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0004175	molecular_function	endopeptidase activity
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005839	cellular_component	proteasome core complex
I	0005886	cellular_component	plasma membrane
I	0009274	cellular_component	peptidoglycan-based cell wall
I	0010498	biological_process	proteasomal protein catabolic process
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0019941	biological_process	modification-dependent protein catabolic process
I	0030682	biological_process	symbiont-mediated perturbation of host defenses
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0004298	molecular_function	threonine-type endopeptidase activity
J	0005839	cellular_component	proteasome core complex
J	0010498	biological_process	proteasomal protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0004175	molecular_function	endopeptidase activity
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005839	cellular_component	proteasome core complex
K	0005886	cellular_component	plasma membrane
K	0009274	cellular_component	peptidoglycan-based cell wall
K	0010498	biological_process	proteasomal protein catabolic process
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0019941	biological_process	modification-dependent protein catabolic process
K	0030682	biological_process	symbiont-mediated perturbation of host defenses
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005839	cellular_component	proteasome core complex
L	0010498	biological_process	proteasomal protein catabolic process
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0004175	molecular_function	endopeptidase activity
M	0004298	molecular_function	threonine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0005886	cellular_component	plasma membrane
M	0009274	cellular_component	peptidoglycan-based cell wall
M	0010498	biological_process	proteasomal protein catabolic process
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0019941	biological_process	modification-dependent protein catabolic process
M	0030682	biological_process	symbiont-mediated perturbation of host defenses
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005839	cellular_component	proteasome core complex
N	0010498	biological_process	proteasomal protein catabolic process
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0004175	molecular_function	endopeptidase activity
O	0004298	molecular_function	threonine-type endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005839	cellular_component	proteasome core complex
O	0005886	cellular_component	plasma membrane
O	0009274	cellular_component	peptidoglycan-based cell wall
O	0010498	biological_process	proteasomal protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0019941	biological_process	modification-dependent protein catabolic process
O	0030682	biological_process	symbiont-mediated perturbation of host defenses
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
P	0004298	molecular_function	threonine-type endopeptidase activity
P	0005839	cellular_component	proteasome core complex
P	0010498	biological_process	proteasomal protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0004175	molecular_function	endopeptidase activity
Q	0004298	molecular_function	threonine-type endopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005839	cellular_component	proteasome core complex
Q	0005886	cellular_component	plasma membrane
Q	0009274	cellular_component	peptidoglycan-based cell wall
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0019941	biological_process	modification-dependent protein catabolic process
Q	0030682	biological_process	symbiont-mediated perturbation of host defenses
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
R	0004298	molecular_function	threonine-type endopeptidase activity
R	0005839	cellular_component	proteasome core complex
R	0010498	biological_process	proteasomal protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0004175	molecular_function	endopeptidase activity
S	0004298	molecular_function	threonine-type endopeptidase activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005839	cellular_component	proteasome core complex
S	0005886	cellular_component	plasma membrane
S	0009274	cellular_component	peptidoglycan-based cell wall
S	0010498	biological_process	proteasomal protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0019941	biological_process	modification-dependent protein catabolic process
S	0030682	biological_process	symbiont-mediated perturbation of host defenses
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
T	0004298	molecular_function	threonine-type endopeptidase activity
T	0005839	cellular_component	proteasome core complex
T	0010498	biological_process	proteasomal protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0004175	molecular_function	endopeptidase activity
U	0004298	molecular_function	threonine-type endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005839	cellular_component	proteasome core complex
U	0005886	cellular_component	plasma membrane
U	0009274	cellular_component	peptidoglycan-based cell wall
U	0010498	biological_process	proteasomal protein catabolic process
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0019941	biological_process	modification-dependent protein catabolic process
U	0030682	biological_process	symbiont-mediated perturbation of host defenses
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0051603	biological_process	proteolysis involved in protein catabolic process
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0010498	biological_process	proteasomal protein catabolic process
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0004175	molecular_function	endopeptidase activity
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0005839	cellular_component	proteasome core complex
W	0005886	cellular_component	plasma membrane
W	0009274	cellular_component	peptidoglycan-based cell wall
W	0010498	biological_process	proteasomal protein catabolic process
W	0019773	cellular_component	proteasome core complex, alpha-subunit complex
W	0019941	biological_process	modification-dependent protein catabolic process
W	0030682	biological_process	symbiont-mediated perturbation of host defenses
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0004298	molecular_function	threonine-type endopeptidase activity
X	0005839	cellular_component	proteasome core complex
X	0010498	biological_process	proteasomal protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0000502	cellular_component	proteasome complex
Y	0004175	molecular_function	endopeptidase activity
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005839	cellular_component	proteasome core complex
Y	0005886	cellular_component	plasma membrane
Y	0009274	cellular_component	peptidoglycan-based cell wall
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Y	0019941	biological_process	modification-dependent protein catabolic process
Y	0030682	biological_process	symbiont-mediated perturbation of host defenses
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005839	cellular_component	proteasome core complex
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF O 7

Chain	Residue
O	LEU74
O	GLY77
O	GLY78
O	TYR103
O	THR106

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF A 8

Chain	Residue
A	THR106
A	LEU74
A	GLY77
A	GLY78
A	TYR103

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF L 9

Chain	Residue
H	DMF142
H	HOH1390
L	TYR472
L	ASP476

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF U 249

Chain	Residue
U	GLY77
U	TYR103
U	THR106

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF B 249

Chain	Residue
B	GLY77
B	VAL102
B	TYR103
B	THR106

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF M 249

Chain	Residue
M	GLY77
M	GLY78
M	TYR103
M	THR106

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF Y 249

Chain	Residue
W	ARG76
Y	ASN101
Y	GLN105
Y	HOH944

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF L 14

Chain	Residue
H	ARG521
L	VAL487
L	HOH1087

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF C 15

Chain	Residue
C	TYR472
C	ASP476
C	HOH543

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF V 16

Chain	Residue
2	HOH554
2	HOH1320
G	ARG521
V	HOH1634

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF G 20

Chain	Residue
G	TYR472
G	ASP476
G	GLY483

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF N 21

Chain	Residue
G	ARG357
N	ALA377
N	ASN381
N	TRP429

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF P 23

Chain	Residue
P	HOH221
P	TYR472
P	ASP476
P	HOH1819

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF K 249

Chain	Residue
K	GLY77
K	VAL102
K	THR106

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Z 27

Chain	Residue
Z	TYR472
Z	ASP476
Z	GLY483

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF E 28

Chain	Residue
C	ARG521
E	HOH273

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF 1 249

Chain	Residue
1	GLY77
1	VAL102
1	TYR103
1	THR106

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF I 249

Chain	Residue
I	GLY77
I	TYR103
I	THR106

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF U 250

Chain	Residue
1	ARG76
U	GLN98
U	ASN101
U	GLN105

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF N 36

Chain	Residue
N	HOH189
N	TYR472
N	ALA475
N	ASP476

---

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Q 249

Chain	Residue
Q	GLY77
Q	GLY78
Q	TYR103

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF H 41

Chain	Residue
H	TYR335
H	ILE336
H	ALA356

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF J 46

Chain	Residue
J	ALA377
J	TRP429
S	ASP90
T	ARG357

---

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF Z 50

Chain	Residue
Z	DMF122
Z	ILE336

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF W 249

Chain	Residue
W	GLY77
W	GLY78
W	TYR103
W	THR106

---

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF K 250

Chain	Residue
K	ARG91
K	ARG219
L	ALA360
L	GLU364

---

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF L 60

Chain	Residue
L	ALA377
L	ASN381
L	TRP429
M	ASP90
N	ARG357

---

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF T 62

Chain	Residue
T	ASP476
T	TYR472

---

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF S 249

Chain	Residue
S	GLY77
S	GLY78
S	VAL102
S	THR106
S	HOH1933

---

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF Z 69

Chain	Residue
Z	ILE496
Z	ARG509

---

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF D 249

Chain	Residue
D	GLY77
D	GLY78
D	TYR103
D	THR106

---

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF F 249

Chain	Residue
F	GLY77
F	TYR103
F	THR106

---

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF K 251

Chain	Residue
D	ARG76
E	GLU370
K	ARG85
K	GLN98
K	ASN101

---

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF 2 99

Chain	Residue
2	TYR472
2	ASP476

---

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF E 104

Chain	Residue
E	ALA377
E	ILE380
E	TRP429
L	ARG357

---

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF Z 105

Chain	Residue
Q	ASP90
R	ARG357
Z	ALA377
Z	TRP429

---

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF P 107

Chain	Residue
H	ARG357
P	ALA377
P	ILE380
P	ASN381
P	TRP429

---

site_id	EC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF S 250

Chain	Residue
S	ARG91
S	ARG219
T	GLU364

---

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF Q 250

Chain	Residue
Q	GLN98
Q	GLN105
Y	ARG76
Z	HOH909

---

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF E 113

Chain	Residue
E	ARG357
R	ALA377
R	ILE380
R	TRP429

---

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF Q 251

Chain	Residue
D	ARG85
D	ASN101
Q	ARG76
R	GLU370

---

site_id	EC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF V 117

Chain	Residue
V	ALA360

---

site_id	EC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF V 121

Chain	Residue
P	ARG357
V	ALA377
V	ILE380
V	TRP429

---

site_id	EC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF Z 122

Chain	Residue
Y	ARG91
Y	ARG219
Z	DMF50
Z	THR337
Z	GLU364

---

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF 1 250

Chain	Residue
1	ARG85
1	GLN105
S	ARG76

---

site_id	FC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF P 133

Chain	Residue
O	ARG91
O	ARG219
P	GLU364

---

site_id	FC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF T 134

Chain	Residue
T	ALA377
T	ASN381
T	TRP429

---

site_id	FC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF V 135

Chain	Residue
G	HOH2
G	ARG319
V	ARG319

---

site_id	FC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF V 136

Chain	Residue
V	LYS333
V	ILE345
V	GLY347
V	ALA352
V	HOH1130
V	HOH1174

---

site_id	FC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF G 137

Chain	Residue
G	HOH194
G	HIS365
G	TYR366
G	LEU369
G	GLU370
W	ARG85
W	TYR89

---

site_id	FC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF L 138

Chain	Residue
L	TYR340
L	PRO373
L	LYS379
L	ILE409

---

site_id	FC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF A 249

Chain	Residue
A	ARG85
A	TYR89
A	HOH252
P	LEU369
P	GLU370

---

site_id	FC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF G 140

Chain	Residue
G	ALA377
G	ILE380
G	TRP429
W	TYR89
W	ASP90
X	ARG357

---

site_id	FC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF X 141

Chain	Residue
2	ARG521
X	VAL487
X	HOH663

---

site_id	GC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF H 142

Chain	Residue
H	HOH217
H	HOH230
H	GLY483
H	PRO484
H	ASP485
L	DMF9

---

site_id	GC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF Y 250

Chain	Residue
Y	GLY77
Y	GLY78
Y	TYR103
Y	THR106

---

site_id	GC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Y 251

Chain	Residue
Y	GLN80
Z	VAL361
Z	HIS365

---

site_id	GC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF 2 145

Chain	Residue
2	ALA377
2	ILE380
2	TRP429
U	ASP90
V	ARG357

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"20711362","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Site: {"description":"Covalent link with the inhibitor MLN-273","evidences":[{"source":"PubMed","id":"16468986","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	56
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"25224505","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
H	SER441
H	GLY347
H	LYS333
H	THR301

---

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
T	SER441
T	GLY347
T	LYS333
T	THR301

---

site_id	CSA11
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
V	SER441
V	GLY347
V	LYS333
V	THR301

---

site_id	CSA12
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
X	SER441
X	GLY347
X	LYS333
X	THR301

---

site_id	CSA13
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
Z	SER441
Z	GLY347
Z	LYS333
Z	THR301

---

site_id	CSA14
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
2	SER441
2	GLY347
2	LYS333
2	THR301

---

site_id	CSA15
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
H	SER441
H	GLY344
H	LYS333
H	THR301

---

site_id	CSA16
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
C	SER441
C	GLY344
C	LYS333
C	THR301

---

site_id	CSA17
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
E	SER441
E	GLY344
E	LYS333
E	THR301

---

site_id	CSA18
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
G	SER441
G	GLY344
G	LYS333
G	THR301

---

site_id	CSA19
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
J	SER441
J	GLY344
J	LYS333
J	THR301

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
C	SER441
C	GLY347
C	LYS333
C	THR301

---

site_id	CSA20
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
L	SER441
L	GLY344
L	LYS333
L	THR301

---

site_id	CSA21
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
N	SER441
N	GLY344
N	LYS333
N	THR301

---

site_id	CSA22
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
P	SER441
P	GLY344
P	LYS333
P	THR301

---

site_id	CSA23
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
R	SER441
R	GLY344
R	LYS333
R	THR301

---

site_id	CSA24
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
T	SER441
T	GLY344
T	LYS333
T	THR301

---

site_id	CSA25
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
V	SER441
V	GLY344
V	LYS333
V	THR301

---

site_id	CSA26
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
X	SER441
X	GLY344
X	LYS333
X	THR301

---

site_id	CSA27
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
Z	SER441
Z	GLY344
Z	LYS333
Z	THR301

---

site_id	CSA28
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
2	SER441
2	GLY344
2	LYS333
2	THR301

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
E	SER441
E	GLY347
E	LYS333
E	THR301

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
G	SER441
G	GLY347
G	LYS333
G	THR301

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
J	SER441
J	GLY347
J	LYS333
J	THR301

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
L	SER441
L	GLY347
L	LYS333
L	THR301

---

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
N	SER441
N	GLY347
N	LYS333
N	THR301

---

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
P	SER441
P	GLY347
P	LYS333
P	THR301

---

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
R	SER441
R	GLY347
R	LYS333
R	THR301

---