3HD7

HELICAL EXTENSION OF THE NEURONAL SNARE COMPLEX INTO THE MEMBRANE, spacegroup C 1 2 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0016192	biological_process	vesicle-mediated transport
B	0005484	molecular_function	SNAP receptor activity
B	0006886	biological_process	intracellular protein transport
B	0016020	cellular_component	membrane
B	0016192	biological_process	vesicle-mediated transport
C	0000149	molecular_function	SNARE binding
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0017075	molecular_function	syntaxin-1 binding
E	0016020	cellular_component	membrane
E	0016192	biological_process	vesicle-mediated transport
F	0005484	molecular_function	SNAP receptor activity
F	0006886	biological_process	intracellular protein transport
F	0016020	cellular_component	membrane
F	0016192	biological_process	vesicle-mediated transport
G	0000149	molecular_function	SNARE binding
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0017075	molecular_function	syntaxin-1 binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GGG E 1

Chain	Residue
E	TYR88
F	ARG262
F	LYS265

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GGG A 1

Chain	Residue
A	LYS85
A	ARG86
B	LYS253
B	TYR257

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GGG A 117

Chain	Residue
F	SO49
F	ARG263
F	MET267
A	TRP89
A	ASN92

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 117

Chain	Residue
E	LYS85
E	ARG86
F	LYS253
F	TYR257

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 2

Chain	Residue
B	LYS260
B	ARG263
F	SO49
F	LYS256
F	LYS260

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 3

Chain	Residue
B	LYS256
B	LYS260
F	SO49
F	LYS260
F	ARG263

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 4

Chain	Residue
C	ASN68
C	LYS72
D	SER187
D	ARG191

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 84

Chain	Residue
C	ARG45

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 7

Chain	Residue
E	GLY26
E	HIS28
E	MET29
F	ARG198

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 9

Chain	Residue
A	ASN92
A	GGG117
B	LYS264
F	SO42
F	SO43
F	LYS260
F	LYS264

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H 10

Chain	Residue
G	ASN68
H	SER187

---

Functional Information from PROSITE/UniProt

site_id	PS00417
Number of Residues	20
Details	SYNAPTOBREVIN Synaptobrevin signature. NVDKVlERdqKLSeLdDRAD

Chain	Residue	Details
A	ASN49-ASP68

---

site_id	PS00914
Number of Residues	40
Details	SYNTAXIN Syntaxin / epimorphin family signature. RhseIikLEnsIrELhdMFmdMamlVesQGemIDrIEyn.V

Chain	Residue	Details
B	ARG198-VAL237

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: (Microbial infection) Cleavage; by C.botulinum neurotoxin type E (BoNT/E) => ECO:0000269|PubMed:8243676, ECO:0000269|PubMed:8294407, ECO:0000305|PubMed:8103915

Chain	Residue	Details
D	ARG180
H	ARG180

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: (Microbial infection) Cleavage; by C.botulinum neurotoxin type A (BoNT/A, botA) => ECO:0000269|PubMed:8243676, ECO:0000269|PubMed:8294407, ECO:0000305|PubMed:8103915

Chain	Residue	Details
D	GLN197
H	GLN197

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P60879

Chain	Residue	Details
D	SER154
H	SER154

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:12459461

Chain	Residue	Details
D	SER187
H	SER187
B	LYS253
B	LYS256
F	LYS252
F	LYS253
F	LYS256

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: (Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X) => ECO:0000269|PubMed:28770820

Chain	Residue	Details
A	ARG66
E	ARG66

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	SITE: (Microbial infection) Cleavage; by C.tetani tetanus toxin (tetX) => ECO:0000269|PubMed:1331807

Chain	Residue	Details
A	GLN76
E	GLN76

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: (Microbial infection) Cleavage; by C.botulinum neurotoxin type G (BoNT/G, botG) => ECO:0000269|PubMed:7910017

Chain	Residue	Details
A	ALA81
E	ALA81

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