3HCT
Crystal structure of TRAF6 in complex with Ubc13 in the P1 space group
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005164 | molecular_function | tumor necrosis factor receptor binding |
| A | 0016567 | biological_process | protein ubiquitination |
| B | 0000151 | cellular_component | ubiquitin ligase complex |
| B | 0000209 | biological_process | protein polyubiquitination |
| B | 0000724 | biological_process | double-strand break repair via homologous recombination |
| B | 0000729 | biological_process | DNA double-strand break processing |
| B | 0001650 | cellular_component | fibrillar center |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006282 | biological_process | regulation of DNA repair |
| B | 0006301 | biological_process | DNA damage tolerance |
| B | 0006513 | biological_process | protein monoubiquitination |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0031371 | cellular_component | ubiquitin conjugating enzyme complex |
| B | 0031372 | cellular_component | UBC13-MMS2 complex |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| B | 0043130 | molecular_function | ubiquitin binding |
| B | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| B | 0045739 | biological_process | positive regulation of DNA repair |
| B | 0050852 | biological_process | T cell receptor signaling pathway |
| B | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070534 | biological_process | protein K63-linked ubiquitination |
| B | 0097027 | molecular_function | ubiquitin-protein transferase activator activity |
| B | 0140374 | biological_process | antiviral innate immune response |
| B | 1902523 | biological_process | positive regulation of protein K63-linked ubiquitination |
| B | 1902533 | biological_process | positive regulation of intracellular signal transduction |
| B | 1904262 | biological_process | negative regulation of TORC1 signaling |
| B | 2000781 | biological_process | positive regulation of double-strand break repair |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | CYS70 |
| A | CYS73 |
| A | CYS90 |
| A | CYS93 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | CYS85 |
| A | HIS87 |
| A | CYS105 |
| A | ASP108 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 303 |
| Chain | Residue |
| A | CYS139 |
| A | HIS151 |
| A | CYS134 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 39 |
| Details | Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"17135271","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19825828","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"18093978","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)","evidences":[{"source":"PubMed","id":"16112642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16122702","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
