Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

3HCT

Crystal structure of TRAF6 in complex with Ubc13 in the P1 space group

Functional Information from GO Data
ChainGOidnamespacecontents
A0004842molecular_functionubiquitin-protein transferase activity
A0005164molecular_functiontumor necrosis factor receptor binding
A0016567biological_processprotein ubiquitination
B0000151cellular_componentubiquitin ligase complex
B0000166molecular_functionnucleotide binding
B0000209biological_processprotein polyubiquitination
B0000724biological_processdouble-strand break repair via homologous recombination
B0000729biological_processDNA double-strand break processing
B0001650cellular_componentfibrillar center
B0003723molecular_functionRNA binding
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006282biological_processregulation of DNA repair
B0006301biological_processDNA damage tolerance
B0006513biological_processprotein monoubiquitination
B0006974biological_processDNA damage response
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0031371cellular_componentubiquitin conjugating enzyme complex
B0031372cellular_componentUBC13-MMS2 complex
B0031625molecular_functionubiquitin protein ligase binding
B0032991cellular_componentprotein-containing complex
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043130molecular_functionubiquitin binding
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045739biological_processpositive regulation of DNA repair
B0050852biological_processT cell receptor signaling pathway
B0061631molecular_functionubiquitin conjugating enzyme activity
B0070062cellular_componentextracellular exosome
B0070534biological_processprotein K63-linked ubiquitination
B0097027molecular_functionubiquitin-protein transferase activator activity
B0140374biological_processantiviral innate immune response
B1902523biological_processpositive regulation of protein K63-linked ubiquitination
B1902533biological_processpositive regulation of intracellular signal transduction
B1904262biological_processnegative regulation of TORC1 signaling
B2000781biological_processpositive regulation of double-strand break repair
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 301
ChainResidue
ACYS70
ACYS73
ACYS90
ACYS93

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 302
ChainResidue
ACYS85
AHIS87
ACYS105
AASP108

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZN A 303
ChainResidue
ACYS139
AHIS151
ACYS134

Functional Information from PROSITE/UniProt
site_idPS00183
Number of Residues16
DetailsUBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNVdkl.GrICLdiL
ChainResidueDetails
BTYR76-LEU91

site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CgHrFCkaCI
ChainResidueDetails
ACYS85-ILE94

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues39
DetailsZinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"17135271","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19825828","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"18093978","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsActive site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)","evidences":[{"source":"PubMed","id":"16112642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16122702","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

PDB statisticsPDBj update infoContact PDBjnumon