3HCS
Crystal structure of the N-terminal domain of TRAF6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005164 | molecular_function | tumor necrosis factor receptor binding |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016567 | biological_process | protein ubiquitination |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005164 | molecular_function | tumor necrosis factor receptor binding |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016567 | biological_process | protein ubiquitination |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | CYS70 |
| A | CYS73 |
| A | CYS90 |
| A | CYS93 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | CYS85 |
| A | HIS87 |
| A | CYS105 |
| A | VAL107 |
| A | ASP108 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 303 |
| Chain | Residue |
| A | CYS134 |
| A | CYS139 |
| A | HIS151 |
| A | CYS155 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 304 |
| Chain | Residue |
| A | CYS162 |
| A | CYS165 |
| A | HIS177 |
| A | CYS182 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 305 |
| Chain | Residue |
| A | CYS189 |
| A | CYS192 |
| A | HIS204 |
| A | CYS208 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 306 |
| Chain | Residue |
| B | CYS70 |
| B | CYS73 |
| B | CYS90 |
| B | CYS93 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 307 |
| Chain | Residue |
| B | CYS85 |
| B | HIS87 |
| B | CYS105 |
| B | ASP108 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 308 |
| Chain | Residue |
| B | CYS134 |
| B | CYS139 |
| B | HIS151 |
| B | CYS155 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 309 |
| Chain | Residue |
| B | CYS162 |
| B | CYS165 |
| B | HIS177 |
| B | CYS182 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 310 |
| Chain | Residue |
| B | CYS189 |
| B | CYS192 |
| B | HIS204 |
| B | CYS208 |
| B | PRO209 |
Functional Information from PROSITE/UniProt
| site_id | PS00518 |
| Number of Residues | 10 |
| Details | ZF_RING_1 Zinc finger RING-type signature. CgHrFCkaCI |
| Chain | Residue | Details |
| A | CYS85-ILE94 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 104 |
| Details | Zinc finger: {"description":"TRAF-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00207","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"17135271","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19825828","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"18093978","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
