Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004129 | molecular_function | cytochrome-c oxidase activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0006119 | biological_process | oxidative phosphorylation |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0009060 | biological_process | aerobic respiration |
A | 0015990 | biological_process | electron transport coupled proton transport |
A | 0016020 | cellular_component | membrane |
A | 0020037 | molecular_function | heme binding |
A | 0045277 | cellular_component | respiratory chain complex IV |
A | 0046872 | molecular_function | metal ion binding |
A | 0070469 | cellular_component | respirasome |
A | 1902600 | biological_process | proton transmembrane transport |
B | 0004129 | molecular_function | cytochrome-c oxidase activity |
B | 0005507 | molecular_function | copper ion binding |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0022900 | biological_process | electron transport chain |
C | 0002250 | biological_process | adaptive immune response |
C | 0002376 | biological_process | immune system process |
C | 0003823 | molecular_function | antigen binding |
C | 0016064 | biological_process | immunoglobulin mediated immune response |
C | 0019814 | cellular_component | immunoglobulin complex |
C | 0072562 | cellular_component | blood microparticle |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE HEA A 559 |
Chain | Residue |
A | LEU36 |
A | VAL103 |
A | GLY163 |
A | TRP164 |
A | TYR406 |
A | PHE412 |
A | HIS413 |
A | MET416 |
A | SER417 |
A | ILE424 |
A | MET452 |
A | THR50 |
A | ILE459 |
A | PHE460 |
A | GLN463 |
A | ARG473 |
A | ARG474 |
A | TYR475 |
A | SER496 |
A | HOH584 |
A | HOH623 |
A | MET53 |
A | ARG54 |
A | TRP87 |
A | ILE91 |
A | HIS94 |
A | MET98 |
A | MET99 |
site_id | AC2 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE HEA A 560 |
Chain | Residue |
A | TRP164 |
A | TRP272 |
A | VAL279 |
A | TYR280 |
A | HIS325 |
A | HIS326 |
A | THR351 |
A | GLY352 |
A | GLY387 |
A | GLY390 |
A | LEU393 |
A | SER394 |
A | ASP399 |
A | HIS403 |
A | VAL408 |
A | HIS411 |
A | PHE412 |
A | VAL415 |
A | MET416 |
A | ARG473 |
A | PEO576 |
A | HOH582 |
A | HOH583 |
A | HOH950 |
A | HOH959 |
B | VAL45 |
B | ILE88 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CU1 A 561 |
Chain | Residue |
A | HIS276 |
A | HIS325 |
A | HIS326 |
A | PEO576 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN A 562 |
Chain | Residue |
A | HIS403 |
A | ASP404 |
A | HOH578 |
B | GLU218 |
B | HOH285 |
B | HOH884 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 563 |
Chain | Residue |
A | GLU56 |
A | HIS59 |
A | GLY61 |
A | GLN63 |
A | HOH851 |
A | HOH965 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE LDA A 564 |
Chain | Residue |
A | ASN457 |
A | PHE461 |
A | LMT572 |
B | LMT279 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE LDA A 565 |
Chain | Residue |
A | LEU72 |
A | ILE73 |
A | LDA567 |
A | LMT571 |
site_id | AC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE LDA A 566 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE LDA A 567 |
Chain | Residue |
A | TYR52 |
A | ALA70 |
A | LEU72 |
A | LDA565 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE LMT A 568 |
Chain | Residue |
A | TRP443 |
A | LEU447 |
A | PHE502 |
A | LMT569 |
A | HOH779 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE LMT A 569 |
Chain | Residue |
A | PRO441 |
A | TRP443 |
A | GLY505 |
A | TYR509 |
A | LMT568 |
D | VAL9 |
site_id | BC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE LMT A 570 |
Chain | Residue |
A | LEU511 |
A | PRO537 |
A | LMT575 |
A | HOH964 |
A | ARG21 |
A | LYS29 |
A | LEU36 |
A | MET435 |
site_id | BC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE LMT A 571 |
Chain | Residue |
A | GLN58 |
A | HIS59 |
A | GLN63 |
A | TYR64 |
A | ALA74 |
A | TYR494 |
A | PHE497 |
A | LDA565 |
A | LMT572 |
A | HOH593 |
A | HOH771 |
A | HOH787 |
site_id | BC5 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE LMT A 572 |
Chain | Residue |
A | TYR484 |
A | ASN487 |
A | ILE488 |
A | ILE491 |
A | LDA564 |
A | LMT571 |
A | HOH787 |
A | HOH1306 |
A | HOH1325 |
site_id | BC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE LMT A 573 |
Chain | Residue |
A | ILE367 |
A | GLU368 |
A | PHE369 |
A | PHE377 |
B | ASN61 |
B | ARG62 |
B | ARG63 |
site_id | BC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE LMT A 574 |
Chain | Residue |
A | MET24 |
A | LEU130 |
A | LEU133 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE LMT A 575 |
Chain | Residue |
A | TRP22 |
A | ARG438 |
A | LEU511 |
A | PHE512 |
A | ARG516 |
A | LMT570 |
site_id | BC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PEO A 576 |
Chain | Residue |
A | HIS276 |
A | HIS325 |
A | HIS326 |
A | HEA560 |
A | CU1561 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CU1 B 270 |
Chain | Residue |
B | CYS216 |
B | GLU218 |
B | CYS220 |
B | HIS224 |
B | CU1271 |
site_id | CC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CU1 B 271 |
Chain | Residue |
B | HIS181 |
B | CYS216 |
B | CYS220 |
B | MET227 |
B | CU1270 |
site_id | CC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE LDA B 272 |
Chain | Residue |
A | THR389 |
A | HIS464 |
B | ASN19 |
B | LDA274 |
site_id | CC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE LDA B 273 |
Chain | Residue |
B | HIS36 |
B | PHE37 |
B | LDA276 |
site_id | CC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE LDA B 274 |
Chain | Residue |
B | TYR40 |
B | LDA272 |
B | HOH1291 |
site_id | CC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE LDA B 275 |
Chain | Residue |
B | ARG102 |
B | LMT278 |
B | LMT280 |
site_id | CC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE LDA B 276 |
Chain | Residue |
B | HIS36 |
B | TYR40 |
B | LDA273 |
site_id | CC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE LMT B 278 |
Chain | Residue |
B | PRO98 |
B | ARG102 |
B | GLU105 |
B | LDA275 |
site_id | CC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE LMT B 279 |
Chain | Residue |
A | PHE461 |
A | TYR484 |
A | TRP485 |
A | LDA564 |
B | ASN15 |
B | GLY16 |
B | MET18 |
site_id | DC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE LMT B 280 |
Chain | Residue |
B | TRP33 |
B | LEU87 |
B | ILE99 |
B | LDA275 |
B | HOH1058 |
B | HOH1118 |
D | ASN28 |
site_id | DC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE LMT B 281 |
Chain | Residue |
A | TRP363 |
B | LEU52 |
B | HIS73 |
B | ASN74 |
B | TRP81 |
B | GLU140 |
B | GLU142 |
B | LMT283 |
site_id | DC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE LMT B 282 |
Chain | Residue |
A | LEU342 |
A | THR346 |
A | VAL349 |
B | VAL86 |
B | LEU89 |
site_id | DC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE LMT B 283 |
Chain | Residue |
A | PHE356 |
B | PHE48 |
B | LEU51 |
B | LEU52 |
B | ILE55 |
B | ILE80 |
B | VAL84 |
B | LMT281 |
B | HOH1330 |
Functional Information from PROSITE/UniProt
site_id | PS00078 |
Number of Residues | 49 |
Details | COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHawtipafavkqdavpgriaqlwfsvdqegvyfgq......CselCginHayM |
Chain | Residue | Details |
B | VAL179-MET227 | |
site_id | PS00077 |
Number of Residues | 55 |
Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiiilpgfgiishvistfakkpifgylpmvlamaaigilgfvvwa..HH |
Chain | Residue | Details |
A | TRP272-HIS326 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 170 |
Details | TOPO_DOM: Periplasmic |
Chain | Residue | Details |
B | GLN1-PRO26 | |
B | MET106-ALA251 | |
A | MET207-VAL217 | |
A | LYS300-PHE303 | |
A | GLY365-PHE369 | |
A | ARG438-TYR440 | |
A | LYS515-HIS558 | |
site_id | SWS_FT_FI2 |
Number of Residues | 62 |
Details | TRANSMEM: Helical |
Chain | Residue | Details |
B | LEU27-ARG59 | |
B | THR75-GLU105 | |
site_id | SWS_FT_FI3 |
Number of Residues | 14 |
Details | TOPO_DOM: Cytoplasmic |
Chain | Residue | Details |
B | PHE60-ASN74 | |
A | PRO152-GLY176 | |
A | GLY252-GLY262 | |
A | MET332 | |
A | ALA396-ASP404 | |
A | GLY470-TYR478 | |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: |
Chain | Residue | Details |
B | HIS181 | |
B | CYS216 | |
B | GLU218 | |
B | CYS220 | |
B | HIS224 | |
B | MET227 | |
site_id | SWS_FT_FI6 |
Number of Residues | 29 |
Details | TRANSMEM: Helical; Name=IV |
Chain | Residue | Details |
A | TYR177-ASN206 | |
site_id | SWS_FT_FI7 |
Number of Residues | 33 |
Details | TRANSMEM: Helical; Name=V |
Chain | Residue | Details |
A | PRO218-PHE251 | |
site_id | SWS_FT_FI8 |
Number of Residues | 36 |
Details | TRANSMEM: Helical; Name=VI |
Chain | Residue | Details |
A | ASP263-LYS299 | |
site_id | SWS_FT_FI9 |
Number of Residues | 27 |
Details | TRANSMEM: Helical; Name=VII |
Chain | Residue | Details |
A | GLY304-GLY331 | |
site_id | SWS_FT_FI10 |
Number of Residues | 31 |
Details | TRANSMEM: Helical; Name=VIII |
Chain | Residue | Details |
A | SER333-GLY364 | |
site_id | SWS_FT_FI11 |
Number of Residues | 25 |
Details | TRANSMEM: Helical; Name=IX |
Chain | Residue | Details |
A | LYS370-GLN395 | |
site_id | SWS_FT_FI12 |
Number of Residues | 32 |
Details | TRANSMEM: Helical; Name=X |
Chain | Residue | Details |
A | THR405-GLY437 | |
site_id | SWS_FT_FI13 |
Number of Residues | 28 |
Details | TRANSMEM: Helical; Name=XI |
Chain | Residue | Details |
A | PRO441-GLN469 | |
site_id | SWS_FT_FI14 |
Number of Residues | 35 |
Details | TRANSMEM: Helical; Name=XII |
Chain | Residue | Details |
A | PRO479-GLY514 | |
site_id | SWS_FT_FI15 |
Number of Residues | 3 |
Details | BINDING: axial binding residue |
Chain | Residue | Details |
A | HIS94 | |
A | HIS411 | |
A | HIS413 | |
site_id | SWS_FT_FI16 |
Number of Residues | 4 |
Details | BINDING: |
Chain | Residue | Details |
A | HIS276 | |
A | TYR280 | |
A | HIS325 | |
A | HIS326 | |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) |
Chain | Residue | Details |
A | HIS276 | |
A | TYR280 | |