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3HAT

ACTIVE SITE MIMETIC INHIBITION OF THROMBIN

Replaces:  2HAT
Functional Information from GO Data
ChainGOidnamespacecontents
H0004252molecular_functionserine-type endopeptidase activity
H0005509molecular_functioncalcium ion binding
H0006508biological_processproteolysis
H0007596biological_processblood coagulation
L0004252molecular_functionserine-type endopeptidase activity
L0005576cellular_componentextracellular region
L0006508biological_processproteolysis
L0007596biological_processblood coagulation
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR CHAIN I OF HIRUGEN
ChainResidue
HARG75
HARG75
HTYR76
HILE82
HMET84
HHOH504
IHOH426
IHOH659
HPHE34
HLYS36
HGLN38
HLEU65
HARG73
HTHR74

site_idAC2
Number of Residues16
DetailsBINDING SITE FOR CHAIN T OF FPAM (FIBRINOPEPTIDE A MIMIC)
ChainResidue
HHIS57
HTYR60
HTRP60
HLEU99
HILE174
HASP189
HALA190
HGLY193
HSER195
HSER214
HTRP215
HGLY216
HGLY219
HHOH407
HHOH571
THOH509

site_idCAT
Number of Residues3
Details
ChainResidue
HHIS57
HASP102
HSER195

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
HLEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV
ChainResidueDetails
HASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
HHIS57
HASP102
HSER195

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923
ChainResidueDetails
HASN60

217705

PDB entries from 2024-03-27

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