3H90
Structural basis for the autoregulation of the zinc transporter YiiP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005381 | molecular_function | iron ion transmembrane transporter activity |
| A | 0005385 | molecular_function | zinc ion transmembrane transporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006829 | biological_process | zinc ion transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0006882 | biological_process | intracellular zinc ion homeostasis |
| A | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| A | 0015086 | molecular_function | cadmium ion transmembrane transporter activity |
| A | 0015093 | molecular_function | ferrous iron transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015341 | molecular_function | zinc efflux active transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034755 | biological_process | iron ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046873 | molecular_function | metal ion transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070574 | biological_process | cadmium ion transmembrane transport |
| A | 0071577 | biological_process | zinc ion transmembrane transport |
| A | 0140826 | molecular_function | zinc:proton antiporter activity |
| B | 0005381 | molecular_function | iron ion transmembrane transporter activity |
| B | 0005385 | molecular_function | zinc ion transmembrane transporter activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0006826 | biological_process | iron ion transport |
| B | 0006829 | biological_process | zinc ion transport |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0006882 | biological_process | intracellular zinc ion homeostasis |
| B | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| B | 0015086 | molecular_function | cadmium ion transmembrane transporter activity |
| B | 0015093 | molecular_function | ferrous iron transmembrane transporter activity |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015341 | molecular_function | zinc efflux active transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0034755 | biological_process | iron ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046873 | molecular_function | metal ion transmembrane transporter activity |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070574 | biological_process | cadmium ion transmembrane transport |
| B | 0071577 | biological_process | zinc ion transmembrane transport |
| B | 0140826 | molecular_function | zinc:proton antiporter activity |
| C | 0005381 | molecular_function | iron ion transmembrane transporter activity |
| C | 0005385 | molecular_function | zinc ion transmembrane transporter activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006812 | biological_process | monoatomic cation transport |
| C | 0006826 | biological_process | iron ion transport |
| C | 0006829 | biological_process | zinc ion transport |
| C | 0006879 | biological_process | intracellular iron ion homeostasis |
| C | 0006882 | biological_process | intracellular zinc ion homeostasis |
| C | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| C | 0015086 | molecular_function | cadmium ion transmembrane transporter activity |
| C | 0015093 | molecular_function | ferrous iron transmembrane transporter activity |
| C | 0015297 | molecular_function | antiporter activity |
| C | 0015341 | molecular_function | zinc efflux active transmembrane transporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0034755 | biological_process | iron ion transmembrane transport |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0046873 | molecular_function | metal ion transmembrane transporter activity |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0070574 | biological_process | cadmium ion transmembrane transport |
| C | 0071577 | biological_process | zinc ion transmembrane transport |
| C | 0140826 | molecular_function | zinc:proton antiporter activity |
| D | 0005381 | molecular_function | iron ion transmembrane transporter activity |
| D | 0005385 | molecular_function | zinc ion transmembrane transporter activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006812 | biological_process | monoatomic cation transport |
| D | 0006826 | biological_process | iron ion transport |
| D | 0006829 | biological_process | zinc ion transport |
| D | 0006879 | biological_process | intracellular iron ion homeostasis |
| D | 0006882 | biological_process | intracellular zinc ion homeostasis |
| D | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| D | 0015086 | molecular_function | cadmium ion transmembrane transporter activity |
| D | 0015093 | molecular_function | ferrous iron transmembrane transporter activity |
| D | 0015297 | molecular_function | antiporter activity |
| D | 0015341 | molecular_function | zinc efflux active transmembrane transporter activity |
| D | 0016020 | cellular_component | membrane |
| D | 0034755 | biological_process | iron ion transmembrane transport |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0046873 | molecular_function | metal ion transmembrane transporter activity |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0070574 | biological_process | cadmium ion transmembrane transport |
| D | 0071577 | biological_process | zinc ion transmembrane transport |
| D | 0140826 | molecular_function | zinc:proton antiporter activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG A 2 |
| Chain | Residue |
| A | ILE26 |
| A | CYS127 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE HG B 4 |
| Chain | Residue |
| B | CYS127 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG C 5 |
| Chain | Residue |
| C | SER229 |
| C | HOH340 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE HG C 6 |
| Chain | Residue |
| C | CYS127 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE HG D 7 |
| Chain | Residue |
| D | SER229 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE HG D 291 |
| Chain | Residue |
| D | CYS127 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1 |
| Chain | Residue |
| C | HIS283 |
| C | ASP285 |
| C | HOH294 |
| A | HIS261 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 2 |
| Chain | Residue |
| C | ASP68 |
| C | HIS71 |
| C | HIS75 |
| C | HOH293 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN C 3 |
| Chain | Residue |
| C | HIS232 |
| C | HIS248 |
| C | ASP285 |
| C | HOH294 |
| C | HOH346 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 4 |
| Chain | Residue |
| A | ASP45 |
| A | ASP49 |
| A | HIS153 |
| A | ASP157 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN D 5 |
| Chain | Residue |
| B | HIS261 |
| B | HOH307 |
| D | HIS283 |
| D | ASP285 |
| D | ZN292 |
| D | HOH335 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 6 |
| Chain | Residue |
| D | ASP68 |
| D | HIS71 |
| D | HIS75 |
| D | HOH295 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN D 292 |
| Chain | Residue |
| D | ZN5 |
| D | HIS232 |
| D | HIS248 |
| D | ASP285 |
| D | HOH294 |
| D | HOH335 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 291 |
| Chain | Residue |
| B | ASP45 |
| B | ASP49 |
| B | HIS153 |
| B | ASP157 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 291 |
| Chain | Residue |
| A | HIS283 |
| A | ASP285 |
| A | HOH298 |
| C | HIS261 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 292 |
| Chain | Residue |
| A | ASP68 |
| A | HIS71 |
| A | HIS75 |
| A | HOH295 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 293 |
| Chain | Residue |
| A | HIS232 |
| A | HIS248 |
| A | ASP285 |
| A | HOH294 |
| A | HOH298 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 291 |
| Chain | Residue |
| C | ASP45 |
| C | ASP49 |
| C | HIS153 |
| C | ASP157 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 292 |
| Chain | Residue |
| B | HIS283 |
| B | ASP285 |
| B | HOH300 |
| D | HIS261 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 293 |
| Chain | Residue |
| B | ASP68 |
| B | HIS71 |
| B | HIS75 |
| B | HOH296 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 294 |
| Chain | Residue |
| B | HIS232 |
| B | HIS248 |
| B | ASP285 |
| B | HOH295 |
| B | HOH300 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 293 |
| Chain | Residue |
| D | ASP45 |
| D | ASP49 |
| D | HIS153 |
| D | ASP157 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 388 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:19749753 |
| Chain | Residue | Details |
| A | THR17-ALA30 | |
| B | VAL118-ARG136 | |
| B | ARG148-VAL158 | |
| B | ASP179-GLY198 | |
| C | THR17-ALA30 | |
| C | ALA42-LEU58 | |
| C | ALA82-GLN103 | |
| C | VAL118-ARG136 | |
| C | ARG148-VAL158 | |
| C | ASP179-GLY198 | |
| D | THR17-ALA30 | |
| A | ALA42-LEU58 | |
| D | ALA42-LEU58 | |
| D | ALA82-GLN103 | |
| D | VAL118-ARG136 | |
| D | ARG148-VAL158 | |
| D | ASP179-GLY198 | |
| A | ALA82-GLN103 | |
| A | VAL118-ARG136 | |
| A | ARG148-VAL158 | |
| A | ASP179-GLY198 | |
| B | THR17-ALA30 | |
| B | ALA42-LEU58 | |
| B | ALA82-GLN103 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 168 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:16049012, ECO:0000269|PubMed:19749753 |
| Chain | Residue | Details |
| A | TRP31-ALA41 | |
| D | TRP31-ALA41 | |
| D | HIS104-GLY117 | |
| D | MET159-ALA178 | |
| A | HIS104-GLY117 | |
| A | MET159-ALA178 | |
| B | TRP31-ALA41 | |
| B | HIS104-GLY117 | |
| B | MET159-ALA178 | |
| C | TRP31-ALA41 | |
| C | HIS104-GLY117 | |
| C | MET159-ALA178 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 128 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:16049012, ECO:0000269|PubMed:19749753 |
| Chain | Residue | Details |
| A | VAL59-LEU81 | |
| A | TRP137-VAL147 | |
| B | VAL59-LEU81 | |
| B | TRP137-VAL147 | |
| C | VAL59-LEU81 | |
| C | TRP137-VAL147 | |
| D | VAL59-LEU81 | |
| D | TRP137-VAL147 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17717154, ECO:0000269|PubMed:19749753, ECO:0000305|PubMed:16790427, ECO:0007744|PDB:2QFI, ECO:0007744|PDB:3H90 |
| Chain | Residue | Details |
| A | ASP45 | |
| D | ASP45 | |
| D | ASP49 | |
| D | HIS153 | |
| A | ASP49 | |
| A | HIS153 | |
| B | ASP45 | |
| B | ASP49 | |
| B | HIS153 | |
| C | ASP45 | |
| C | ASP49 | |
| C | HIS153 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17717154, ECO:0000269|PubMed:19749753, ECO:0007744|PDB:2QFI, ECO:0007744|PDB:3H90 |
| Chain | Residue | Details |
| A | ASP68 | |
| A | HIS75 | |
| B | ASP68 | |
| B | HIS75 | |
| C | ASP68 | |
| C | HIS75 | |
| D | ASP68 | |
| D | HIS75 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19749753, ECO:0007744|PDB:3H90 |
| Chain | Residue | Details |
| A | HIS71 | |
| B | HIS261 | |
| B | HIS283 | |
| B | ASP285 | |
| C | HIS71 | |
| C | HIS232 | |
| C | HIS248 | |
| C | HIS261 | |
| C | HIS283 | |
| C | ASP285 | |
| D | HIS71 | |
| A | HIS232 | |
| D | HIS232 | |
| D | HIS248 | |
| D | HIS261 | |
| D | HIS283 | |
| D | ASP285 | |
| A | HIS248 | |
| A | HIS261 | |
| A | HIS283 | |
| A | ASP285 | |
| B | HIS71 | |
| B | HIS232 | |
| B | HIS248 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17717154, ECO:0000269|PubMed:19749753, ECO:0000305|PubMed:16049012, ECO:0007744|PDB:2QFI, ECO:0007744|PDB:3H90 |
| Chain | Residue | Details |
| A | ASP157 | |
| B | ASP157 | |
| C | ASP157 | |
| D | ASP157 |
