Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3H90

Structural basis for the autoregulation of the zinc transporter YiiP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005381	molecular_function	iron ion transmembrane transporter activity
A	0005385	molecular_function	zinc ion transmembrane transporter activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006826	biological_process	iron ion transport
A	0006829	biological_process	zinc ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006882	biological_process	intracellular zinc ion homeostasis
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0015086	molecular_function	cadmium ion transmembrane transporter activity
A	0015093	molecular_function	ferrous iron transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015341	molecular_function	zinc efflux antiporter activity
A	0016020	cellular_component	membrane
A	0034755	biological_process	iron ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0070574	biological_process	cadmium ion transmembrane transport
A	0071577	biological_process	zinc ion transmembrane transport
A	0140826	molecular_function	zinc:proton antiporter activity
B	0005381	molecular_function	iron ion transmembrane transporter activity
B	0005385	molecular_function	zinc ion transmembrane transporter activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0006826	biological_process	iron ion transport
B	0006829	biological_process	zinc ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006882	biological_process	intracellular zinc ion homeostasis
B	0008324	molecular_function	monoatomic cation transmembrane transporter activity
B	0015086	molecular_function	cadmium ion transmembrane transporter activity
B	0015093	molecular_function	ferrous iron transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0015341	molecular_function	zinc efflux antiporter activity
B	0016020	cellular_component	membrane
B	0034755	biological_process	iron ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0046873	molecular_function	metal ion transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
B	0070574	biological_process	cadmium ion transmembrane transport
B	0071577	biological_process	zinc ion transmembrane transport
B	0140826	molecular_function	zinc:proton antiporter activity
C	0005381	molecular_function	iron ion transmembrane transporter activity
C	0005385	molecular_function	zinc ion transmembrane transporter activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0006826	biological_process	iron ion transport
C	0006829	biological_process	zinc ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006882	biological_process	intracellular zinc ion homeostasis
C	0008324	molecular_function	monoatomic cation transmembrane transporter activity
C	0015086	molecular_function	cadmium ion transmembrane transporter activity
C	0015093	molecular_function	ferrous iron transmembrane transporter activity
C	0015297	molecular_function	antiporter activity
C	0015341	molecular_function	zinc efflux antiporter activity
C	0016020	cellular_component	membrane
C	0034755	biological_process	iron ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0046873	molecular_function	metal ion transmembrane transporter activity
C	0055085	biological_process	transmembrane transport
C	0070574	biological_process	cadmium ion transmembrane transport
C	0071577	biological_process	zinc ion transmembrane transport
C	0140826	molecular_function	zinc:proton antiporter activity
D	0005381	molecular_function	iron ion transmembrane transporter activity
D	0005385	molecular_function	zinc ion transmembrane transporter activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006812	biological_process	monoatomic cation transport
D	0006826	biological_process	iron ion transport
D	0006829	biological_process	zinc ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006882	biological_process	intracellular zinc ion homeostasis
D	0008324	molecular_function	monoatomic cation transmembrane transporter activity
D	0015086	molecular_function	cadmium ion transmembrane transporter activity
D	0015093	molecular_function	ferrous iron transmembrane transporter activity
D	0015297	molecular_function	antiporter activity
D	0015341	molecular_function	zinc efflux antiporter activity
D	0016020	cellular_component	membrane
D	0034755	biological_process	iron ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0046873	molecular_function	metal ion transmembrane transporter activity
D	0055085	biological_process	transmembrane transport
D	0070574	biological_process	cadmium ion transmembrane transport
D	0071577	biological_process	zinc ion transmembrane transport
D	0140826	molecular_function	zinc:proton antiporter activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG A 2

Chain	Residue
A	ILE26
A	CYS127

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HG B 4

Chain	Residue
B	CYS127

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG C 5

Chain	Residue
C	SER229
C	HOH340

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HG C 6

Chain	Residue
C	CYS127

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HG D 7

Chain	Residue
D	SER229

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE HG D 291

Chain	Residue
D	CYS127

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
C	HIS283
C	ASP285
C	HOH294
A	HIS261

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 2

Chain	Residue
C	ASP68
C	HIS71
C	HIS75
C	HOH293

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 3

Chain	Residue
C	HIS232
C	HIS248
C	ASP285
C	HOH294
C	HOH346

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 4

Chain	Residue
A	ASP45
A	ASP49
A	HIS153
A	ASP157

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN D 5

Chain	Residue
B	HIS261
B	HOH307
D	HIS283
D	ASP285
D	ZN292
D	HOH335

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 6

Chain	Residue
D	ASP68
D	HIS71
D	HIS75
D	HOH295

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN D 292

Chain	Residue
D	ZN5
D	HIS232
D	HIS248
D	ASP285
D	HOH294
D	HOH335

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 291

Chain	Residue
B	ASP45
B	ASP49
B	HIS153
B	ASP157

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 291

Chain	Residue
A	HIS283
A	ASP285
A	HOH298
C	HIS261

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 292

Chain	Residue
A	ASP68
A	HIS71
A	HIS75
A	HOH295

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 293

Chain	Residue
A	HIS232
A	HIS248
A	ASP285
A	HOH294
A	HOH298

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 291

Chain	Residue
C	ASP45
C	ASP49
C	HIS153
C	ASP157

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 292

Chain	Residue
B	HIS283
B	ASP285
B	HOH300
D	HIS261

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 293

Chain	Residue
B	ASP68
B	HIS71
B	HIS75
B	HOH296

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 294

Chain	Residue
B	HIS232
B	HIS248
B	ASP285
B	HOH295
B	HOH300

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 293

Chain	Residue
D	ASP45
D	ASP49
D	HIS153
D	ASP157

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	388
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"19749753","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	168
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"16049012","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19749753","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	128
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"16049012","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19749753","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17717154","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19749753","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16790427","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H90","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17717154","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19749753","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H90","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19749753","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3H90","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17717154","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19749753","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16049012","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QFI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H90","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)