3H8V
Human Ubiquitin-activating Enzyme 5 in Complex with ATP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 401 |
| Chain | Residue |
| A | CYS226 |
| A | CYS229 |
| A | CYS303 |
| A | CYS308 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ATP A 402 |
| Chain | Residue |
| A | ASP106 |
| A | LYS127 |
| A | ASN150 |
| A | THR152 |
| A | CYS181 |
| A | VAL182 |
| A | ASP183 |
| A | ASN184 |
| A | ALA187 |
| A | HOH442 |
| A | HOH463 |
| A | GLY80 |
| A | GLY82 |
| A | GLY83 |
| A | ASP104 |
| A | TYR105 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 401 |
| Chain | Residue |
| B | CYS226 |
| B | CYS229 |
| B | CYS303 |
| B | CYS308 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 29 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. VAIVGvGGVGsvtaemltrcgigkLLlFD |
| Chain | Residue | Details |
| A | VAL76-ASP104 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Glycyl thioester intermediate => ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27653677 |
| Chain | Residue | Details |
| A | CYS250 | |
| B | CYS250 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:30412706, ECO:0007744|PDB:5L95, ECO:0007744|PDB:6H77, ECO:0007744|PDB:6H78 |
| Chain | Residue | Details |
| A | GLY83 | |
| A | LYS127 | |
| A | ASN150 | |
| A | ASN184 | |
| B | GLY83 | |
| B | LYS127 | |
| B | ASN150 | |
| B | ASN184 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:30412706, ECO:0007744|PDB:5L95, ECO:0007744|PDB:6H78 |
| Chain | Residue | Details |
| A | ASP104 | |
| B | ASP104 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:30412706, ECO:0007744|PDB:5IAA, ECO:0007744|PDB:5L95, ECO:0007744|PDB:6H77, ECO:0007744|PDB:6H78 |
| Chain | Residue | Details |
| A | CYS226 | |
| A | CYS229 | |
| A | CYS303 | |
| A | CYS308 | |
| B | CYS226 | |
| B | CYS229 | |
| B | CYS303 | |
| B | CYS308 |
