Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3H6I

Crystal Structure of Mycobacterium Tuberculosis Proteasome Modified by inhibitor GL1

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005515	molecular_function	protein binding
1	0005737	cellular_component	cytoplasm
1	0005839	cellular_component	proteasome core complex
1	0005886	cellular_component	plasma membrane
1	0010498	biological_process	proteasomal protein catabolic process
1	0019773	cellular_component	proteasome core complex, alpha-subunit complex
1	0019941	biological_process	modification-dependent protein catabolic process
1	0030163	biological_process	protein catabolic process
1	0030682	biological_process	symbiont-mediated perturbation of host defenses
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005839	cellular_component	proteasome core complex
2	0010498	biological_process	proteasomal protein catabolic process
2	0030163	biological_process	protein catabolic process
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0005886	cellular_component	plasma membrane
A	0010498	biological_process	proteasomal protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0019941	biological_process	modification-dependent protein catabolic process
A	0030163	biological_process	protein catabolic process
A	0030682	biological_process	symbiont-mediated perturbation of host defenses
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0004175	molecular_function	endopeptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0005886	cellular_component	plasma membrane
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0019941	biological_process	modification-dependent protein catabolic process
B	0030163	biological_process	protein catabolic process
B	0030682	biological_process	symbiont-mediated perturbation of host defenses
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005839	cellular_component	proteasome core complex
C	0010498	biological_process	proteasomal protein catabolic process
C	0030163	biological_process	protein catabolic process
D	0004175	molecular_function	endopeptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0005886	cellular_component	plasma membrane
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0019941	biological_process	modification-dependent protein catabolic process
D	0030163	biological_process	protein catabolic process
D	0030682	biological_process	symbiont-mediated perturbation of host defenses
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005839	cellular_component	proteasome core complex
E	0010498	biological_process	proteasomal protein catabolic process
E	0030163	biological_process	protein catabolic process
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0005886	cellular_component	plasma membrane
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0019941	biological_process	modification-dependent protein catabolic process
F	0030163	biological_process	protein catabolic process
F	0030682	biological_process	symbiont-mediated perturbation of host defenses
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0004298	molecular_function	threonine-type endopeptidase activity
G	0005839	cellular_component	proteasome core complex
G	0010498	biological_process	proteasomal protein catabolic process
G	0030163	biological_process	protein catabolic process
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0010498	biological_process	proteasomal protein catabolic process
H	0030163	biological_process	protein catabolic process
I	0004175	molecular_function	endopeptidase activity
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005839	cellular_component	proteasome core complex
I	0005886	cellular_component	plasma membrane
I	0010498	biological_process	proteasomal protein catabolic process
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0019941	biological_process	modification-dependent protein catabolic process
I	0030163	biological_process	protein catabolic process
I	0030682	biological_process	symbiont-mediated perturbation of host defenses
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0004298	molecular_function	threonine-type endopeptidase activity
J	0005839	cellular_component	proteasome core complex
J	0010498	biological_process	proteasomal protein catabolic process
J	0030163	biological_process	protein catabolic process
K	0004175	molecular_function	endopeptidase activity
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005839	cellular_component	proteasome core complex
K	0005886	cellular_component	plasma membrane
K	0010498	biological_process	proteasomal protein catabolic process
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0019941	biological_process	modification-dependent protein catabolic process
K	0030163	biological_process	protein catabolic process
K	0030682	biological_process	symbiont-mediated perturbation of host defenses
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005839	cellular_component	proteasome core complex
L	0010498	biological_process	proteasomal protein catabolic process
L	0030163	biological_process	protein catabolic process
M	0004175	molecular_function	endopeptidase activity
M	0004298	molecular_function	threonine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0005886	cellular_component	plasma membrane
M	0010498	biological_process	proteasomal protein catabolic process
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0019941	biological_process	modification-dependent protein catabolic process
M	0030163	biological_process	protein catabolic process
M	0030682	biological_process	symbiont-mediated perturbation of host defenses
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005839	cellular_component	proteasome core complex
N	0010498	biological_process	proteasomal protein catabolic process
N	0030163	biological_process	protein catabolic process
O	0004175	molecular_function	endopeptidase activity
O	0004298	molecular_function	threonine-type endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005839	cellular_component	proteasome core complex
O	0005886	cellular_component	plasma membrane
O	0010498	biological_process	proteasomal protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0019941	biological_process	modification-dependent protein catabolic process
O	0030163	biological_process	protein catabolic process
O	0030682	biological_process	symbiont-mediated perturbation of host defenses
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0004298	molecular_function	threonine-type endopeptidase activity
P	0005839	cellular_component	proteasome core complex
P	0010498	biological_process	proteasomal protein catabolic process
P	0030163	biological_process	protein catabolic process
Q	0004175	molecular_function	endopeptidase activity
Q	0004298	molecular_function	threonine-type endopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005839	cellular_component	proteasome core complex
Q	0005886	cellular_component	plasma membrane
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0019941	biological_process	modification-dependent protein catabolic process
Q	0030163	biological_process	protein catabolic process
Q	0030682	biological_process	symbiont-mediated perturbation of host defenses
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0004298	molecular_function	threonine-type endopeptidase activity
R	0005839	cellular_component	proteasome core complex
R	0010498	biological_process	proteasomal protein catabolic process
R	0030163	biological_process	protein catabolic process
S	0004175	molecular_function	endopeptidase activity
S	0004298	molecular_function	threonine-type endopeptidase activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005839	cellular_component	proteasome core complex
S	0005886	cellular_component	plasma membrane
S	0010498	biological_process	proteasomal protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0019941	biological_process	modification-dependent protein catabolic process
S	0030163	biological_process	protein catabolic process
S	0030682	biological_process	symbiont-mediated perturbation of host defenses
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0004298	molecular_function	threonine-type endopeptidase activity
T	0005839	cellular_component	proteasome core complex
T	0010498	biological_process	proteasomal protein catabolic process
T	0030163	biological_process	protein catabolic process
U	0004175	molecular_function	endopeptidase activity
U	0004298	molecular_function	threonine-type endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005839	cellular_component	proteasome core complex
U	0005886	cellular_component	plasma membrane
U	0010498	biological_process	proteasomal protein catabolic process
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0019941	biological_process	modification-dependent protein catabolic process
U	0030163	biological_process	protein catabolic process
U	0030682	biological_process	symbiont-mediated perturbation of host defenses
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0010498	biological_process	proteasomal protein catabolic process
V	0030163	biological_process	protein catabolic process
W	0004175	molecular_function	endopeptidase activity
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0005839	cellular_component	proteasome core complex
W	0005886	cellular_component	plasma membrane
W	0010498	biological_process	proteasomal protein catabolic process
W	0019773	cellular_component	proteasome core complex, alpha-subunit complex
W	0019941	biological_process	modification-dependent protein catabolic process
W	0030163	biological_process	protein catabolic process
W	0030682	biological_process	symbiont-mediated perturbation of host defenses
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0004298	molecular_function	threonine-type endopeptidase activity
X	0005839	cellular_component	proteasome core complex
X	0010498	biological_process	proteasomal protein catabolic process
X	0030163	biological_process	protein catabolic process
Y	0004175	molecular_function	endopeptidase activity
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005839	cellular_component	proteasome core complex
Y	0005886	cellular_component	plasma membrane
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Y	0019941	biological_process	modification-dependent protein catabolic process
Y	0030163	biological_process	protein catabolic process
Y	0030682	biological_process	symbiont-mediated perturbation of host defenses
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005839	cellular_component	proteasome core complex
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0030163	biological_process	protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF A 249

Chain	Residue
A	GLY77
A	VAL102

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF A 250

Chain	Residue
A	ARG91
A	ARG219
A	HOH1213
H	GLU364
H	HOH2272

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF B 249

Chain	Residue
B	THR106
B	GLY77
B	VAL102

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF B 250

Chain	Residue
B	ARG91
B	ARG219
C	GLU364
C	HOH1685

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF B 251

Chain	Residue
B	THR84
C	VAL361
C	HOH2184

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF C 5

Chain	Residue
C	GLU432
C	GLU434
C	TYR436
C	GLN437
C	LYS447

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF C 15

Chain	Residue
C	TYR472
C	ASP476
E	HOH1090

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF C 17

Chain	Residue
C	ILE336
C	ARG357
C	HOH1355
C	HOH1685

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF C 28

Chain	Residue
C	ARG521
C	HOH554

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF C 43

Chain	Residue
C	ASN381
C	ILE385
I	TYR87
J	ARG357

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF C 48

Chain	Residue
C	ALA377
C	TRP429
J	ARG357
J	HOH2224

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF C 64

Chain	Residue
C	ILE496
C	ASP498
C	HOH2195

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF C 73

Chain	Residue
C	SER441
C	GLY442
C	SER443
C	LEU444
C	PHE445
C	HOH2325

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF D 249

Chain	Residue
D	GLN51
D	SER54
D	ARG75
E	LYS368
E	GLY371
K	ARG97

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF D 250

Chain	Residue
D	TYR87
E	ARG357
R	ASN381

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF D 251

Chain	Residue
D	GLY77
D	TYR103

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF D 252

Chain	Residue
D	ARG91
D	ARG219
E	ALA360
E	GLU364

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF E 32

Chain	Residue
E	TYR472
E	ASP476

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF E 44

Chain	Residue
E	TYR335
E	VAL353
E	ARG357
E	ALA360

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF E 55

Chain	Residue
D	ARG76
E	GLU370
K	ARG85
K	GLN98
K	HOH2288

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF E 70

Chain	Residue
E	ILE380
E	ASN381
E	TRP429
E	HOH2196
L	ARG357

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF E 83

Chain	Residue
E	GLU354
E	ARG357
R	ALA377
R	ILE380
R	ASN381
R	TRP429

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF E 95

Chain	Residue
E	TRP429
E	ASN430
E	ILE431
L	ALA349

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF F 249

Chain	Residue
F	VAL102
F	TYR103

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF F 250

Chain	Residue
F	GLN51
F	ASP72
F	ARG75
G	LEU369
W	ARG97

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF G 1

Chain	Residue
G	ARG357
G	TYR335
G	ILE336
G	VAL353

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF G 20

Chain	Residue
G	TYR472
G	ALA475
G	ASP476
G	HOH2328
V	HOH866
V	HOH2223

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF G 39

Chain	Residue
2	LYS452
G	LYS452

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF G 96

Chain	Residue
G	LYS447
G	HOH2284
G	HOH2327
X	ILE326
X	HOH867

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF H 14

Chain	Residue
H	ARG521
H	HOH598

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF H 19

Chain	Residue
H	HOH2377
L	HOH1904
P	HOH1044

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF H 31

Chain	Residue
H	ALA475
H	ASP476
H	HOH553
L	HOH928
L	HOH2384

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF H 41

Chain	Residue
A	HOH2428
H	ILE336

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF H 52

Chain	Residue
H	VAL487
H	ARG488
H	GLY489

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF H 53

Chain	Residue
C	VAL353
H	TRP429
H	ASN430
H	ILE431
H	HOH819

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF H 102

Chain	Residue
C	ARG357
H	TRP429

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF I 249

Chain	Residue
I	ARG91
I	ARG219
J	ALA360

site_id	EC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF I 250

Chain	Residue
I	TYR103

site_id	EC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF J 6

Chain	Residue
J	SER320
J	THR321
J	GLY347

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF J 59

Chain	Residue
J	ILE336
J	VAL353
J	ARG357
J	HOH1852

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF J 82

Chain	Residue
J	TYR472
J	ASP476
J	HOH2332
R	HOH2080

site_id	EC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF K 249

Chain	Residue
K	GLY77
K	TYR103

site_id	EC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF K 250

Chain	Residue
K	ARG91
K	ARG219
K	HOH2137
L	DMF4
L	VAL361
L	GLU364

site_id	EC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF L 4

Chain	Residue
K	DMF250
K	HOH2351
L	ILE336

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF L 9

Chain	Residue
H	HOH811
L	TYR472
L	ASP476

site_id	FC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF L 60

Chain	Residue
L	ALA377
L	ASN381
L	TRP429
N	GLU354
N	ARG357
N	HOH2035

site_id	FC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF M 249

Chain	Residue
M	GLY77
M	VAL102
M	TYR103

site_id	FC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF M 250

Chain	Residue
M	ARG91
M	ARG219
M	HOH1926
N	ALA360

site_id	FC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF N 2

Chain	Residue
N	HOH134
N	ARG521
N	HOH1467
P	VAL487
P	ARG488
P	HOH2424

site_id	FC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF N 21

Chain	Residue
G	GLU354
G	ARG357
N	ALA377
N	ASN381
N	TRP429

site_id	FC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF N 24

Chain	Residue
N	TYR335
N	ILE336
N	ALA360

site_id	FC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF N 36

Chain	Residue
N	TYR472
N	ASP476

site_id	FC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF N 37

Chain	Residue
N	ARG388
N	ASN390
N	ALA425

site_id	FC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF N 97

Chain	Residue
N	GLY440
N	SER441
N	SER443
N	LEU444

site_id	GC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF N 99

Chain	Residue
G	ALA349
G	HOH890
N	TRP429
N	ASN430
N	ILE431

site_id	GC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF O 249

Chain	Residue
O	GLY77
O	VAL102
O	TYR103
O	THR106

site_id	GC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF O 250

Chain	Residue
O	ARG91
O	ARG219
O	HOH2047
P	ALA360
P	VAL361
P	GLU364

site_id	GC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF P 23

Chain	Residue
P	TYR472
P	ALA475
P	ASP476
P	HOH960

site_id	GC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF P 61

Chain	Residue
P	ILE496

site_id	GC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF P 74

Chain	Residue
H	GLU354
H	ARG357
P	ALA377
P	ILE380
P	ASN381
P	TRP429

site_id	GC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF P 85

Chain	Residue
H	TYR335
H	ALA349
P	TRP429
P	ASN430
P	ILE431

site_id	GC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF P 100

Chain	Residue
O	HOH1055
P	ILE336

site_id	GC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Q 249

Chain	Residue
Q	GLY77
Q	VAL102
Q	THR106

site_id	HC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Q 250

Chain	Residue
D	GLN98
Q	ARG76
R	GLU370

site_id	HC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF R 3

Chain	Residue
J	ARG521
R	VAL487
R	ARG488
R	HOH545
Z	HOH1378

site_id	HC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF R 54

Chain	Residue
R	TYR335
R	HOH1631

site_id	HC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF R 68

Chain	Residue
R	TYR472
R	ALA475
R	ASP476
R	HOH911
R	HOH2425

site_id	HC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF R 89

Chain	Residue
Q	ARG91
Q	ARG219
R	ALA360
R	GLU364

site_id	HC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF S 249

Chain	Residue
S	GLY77
S	TYR103

site_id	HC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF S 250

Chain	Residue
S	ARG91
S	ARG219
T	ALA360

site_id	HC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF S 251

Chain	Residue
1	ARG85
1	GLN98
S	ARG76
T	GLU370

site_id	HC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF T 35

Chain	Residue
T	ASP338
T	TYR340
T	PRO373
T	LYS379
T	HOH994

site_id	IC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF T 46

Chain	Residue
T	TYR335
T	ILE336
T	ALA360

site_id	IC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF T 62

Chain	Residue
T	TYR472
T	ALA475
T	ASP476
Z	HOH554

site_id	IC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF T 92

Chain	Residue
2	ALA349
2	VAL353
T	TRP429
T	ASN430
T	ILE431

site_id	IC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF T 94

Chain	Residue
T	ARG318
T	ASP330
T	ARG332
T	HOH2165

site_id	IC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF U 249

Chain	Residue
U	TYR103
U	THR106

site_id	IC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF U 250

Chain	Residue
1	ARG76
U	GLN98
U	ASN101
U	VAL102

site_id	IC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF U 251

Chain	Residue
U	ARG91
U	ARG219
V	DMF86
V	HOH999
V	HOH2355

site_id	IC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF U 252

Chain	Residue
2	ASN381
2	ILE385
2	HOH2315
U	TYR87
U	HOH1610
V	ARG357

site_id	IC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF V 16

Chain	Residue
2	HOH2372
V	ARG488
V	HOH2415

site_id	JC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF V 86

Chain	Residue
U	DMF251
V	ILE336
V	VAL353
V	ARG357
V	ALA360
V	HOH999

site_id	JC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF V 90

Chain	Residue
V	ALA377
V	ILE380
V	ASN381
V	TRP429

site_id	JC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF W 249

Chain	Residue
W	ARG76
Y	PHE81
Y	ARG85

site_id	JC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF W 250

Chain	Residue
W	TYR103

site_id	JC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF X 25

Chain	Residue
X	ILE336

site_id	JC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF X 67

Chain	Residue
X	ILE496
X	ASP498
X	VAL503

site_id	JC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF X 88

Chain	Residue
W	ARG219
X	ARG357
X	ALA360
X	VAL361
X	HOH2103

site_id	JC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Y 249

Chain	Residue
Q	GLN98
Y	ARG76
Z	GLU370

site_id	JC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF Z 27

Chain	Residue
Z	TYR472
Z	ASP476
Z	GLY483
Z	HOH2076

site_id	KC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Z 50

Chain	Residue
Z	ILE336
Z	ARG357
Z	HOH1148

site_id	KC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Z 69

Chain	Residue
Z	ILE496
Z	VAL503
Z	HOH2391

site_id	KC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Z 71

Chain	Residue
R	ARG357
Z	TRP429
Z	HOH2095

site_id	KC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF Z 79

Chain	Residue
R	TYR335
R	ALA349
R	HOH1034
Z	TRP429
Z	ASN430
Z	ILE431

site_id	KC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF Z 91

Chain	Residue
Y	ARG91
Y	ARG219
Z	ALA360
Z	GLU364
Z	HOH1148

site_id	KC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF 1 249

Chain	Residue
1	LEU74
1	GLY77
1	TYR103
1	THR106

site_id	KC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF 1 250

Chain	Residue
1	THR84
1	HOH1918
2	LEU358

site_id	KC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF 1 251

Chain	Residue
1	ARG91
1	ARG219
1	HOH545
2	DMF78
2	ARG357
2	VAL361
2	GLU364

site_id	KC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF 2 58

Chain	Residue
2	ALA475
2	GLY483
2	PRO484

site_id	LC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF 2 66

Chain	Residue
2	ASP498
2	ARG509

site_id	LC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF 2 78

Chain	Residue
1	DMF251
2	TYR335
2	ILE336
2	VAL353
2	HOH2070

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"25224505","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)