3H6I

Crystal Structure of Mycobacterium Tuberculosis Proteasome Modified by inhibitor GL1

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000502	cellular_component	proteasome complex
1	0003824	molecular_function	catalytic activity
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005515	molecular_function	protein binding
1	0005737	cellular_component	cytoplasm
1	0005839	cellular_component	proteasome core complex
1	0005886	cellular_component	plasma membrane
1	0009274	cellular_component	peptidoglycan-based cell wall
1	0010498	biological_process	proteasomal protein catabolic process
1	0019773	cellular_component	proteasome core complex, alpha-subunit complex
1	0019941	biological_process	modification-dependent protein catabolic process
1	0030682	biological_process	symbiont-mediated perturbation of host defenses
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
1	0051603	biological_process	proteolysis involved in protein catabolic process
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005839	cellular_component	proteasome core complex
2	0010498	biological_process	proteasomal protein catabolic process
2	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0003824	molecular_function	catalytic activity
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0010498	biological_process	proteasomal protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0019941	biological_process	modification-dependent protein catabolic process
A	0030682	biological_process	symbiont-mediated perturbation of host defenses
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0003824	molecular_function	catalytic activity
B	0004175	molecular_function	endopeptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0005886	cellular_component	plasma membrane
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0019941	biological_process	modification-dependent protein catabolic process
B	0030682	biological_process	symbiont-mediated perturbation of host defenses
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005839	cellular_component	proteasome core complex
C	0010498	biological_process	proteasomal protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0003824	molecular_function	catalytic activity
D	0004175	molecular_function	endopeptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0005886	cellular_component	plasma membrane
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0019941	biological_process	modification-dependent protein catabolic process
D	0030682	biological_process	symbiont-mediated perturbation of host defenses
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005839	cellular_component	proteasome core complex
E	0010498	biological_process	proteasomal protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0003824	molecular_function	catalytic activity
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0005886	cellular_component	plasma membrane
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0019941	biological_process	modification-dependent protein catabolic process
F	0030682	biological_process	symbiont-mediated perturbation of host defenses
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0004298	molecular_function	threonine-type endopeptidase activity
G	0005839	cellular_component	proteasome core complex
G	0010498	biological_process	proteasomal protein catabolic process
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0010498	biological_process	proteasomal protein catabolic process
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0003824	molecular_function	catalytic activity
I	0004175	molecular_function	endopeptidase activity
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005839	cellular_component	proteasome core complex
I	0005886	cellular_component	plasma membrane
I	0009274	cellular_component	peptidoglycan-based cell wall
I	0010498	biological_process	proteasomal protein catabolic process
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0019941	biological_process	modification-dependent protein catabolic process
I	0030682	biological_process	symbiont-mediated perturbation of host defenses
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0004298	molecular_function	threonine-type endopeptidase activity
J	0005839	cellular_component	proteasome core complex
J	0010498	biological_process	proteasomal protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0003824	molecular_function	catalytic activity
K	0004175	molecular_function	endopeptidase activity
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005839	cellular_component	proteasome core complex
K	0005886	cellular_component	plasma membrane
K	0009274	cellular_component	peptidoglycan-based cell wall
K	0010498	biological_process	proteasomal protein catabolic process
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0019941	biological_process	modification-dependent protein catabolic process
K	0030682	biological_process	symbiont-mediated perturbation of host defenses
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005839	cellular_component	proteasome core complex
L	0010498	biological_process	proteasomal protein catabolic process
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0003824	molecular_function	catalytic activity
M	0004175	molecular_function	endopeptidase activity
M	0004298	molecular_function	threonine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0005886	cellular_component	plasma membrane
M	0009274	cellular_component	peptidoglycan-based cell wall
M	0010498	biological_process	proteasomal protein catabolic process
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0019941	biological_process	modification-dependent protein catabolic process
M	0030682	biological_process	symbiont-mediated perturbation of host defenses
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005839	cellular_component	proteasome core complex
N	0010498	biological_process	proteasomal protein catabolic process
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0003824	molecular_function	catalytic activity
O	0004175	molecular_function	endopeptidase activity
O	0004298	molecular_function	threonine-type endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005839	cellular_component	proteasome core complex
O	0005886	cellular_component	plasma membrane
O	0009274	cellular_component	peptidoglycan-based cell wall
O	0010498	biological_process	proteasomal protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0019941	biological_process	modification-dependent protein catabolic process
O	0030682	biological_process	symbiont-mediated perturbation of host defenses
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
P	0004298	molecular_function	threonine-type endopeptidase activity
P	0005839	cellular_component	proteasome core complex
P	0010498	biological_process	proteasomal protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0003824	molecular_function	catalytic activity
Q	0004175	molecular_function	endopeptidase activity
Q	0004298	molecular_function	threonine-type endopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005839	cellular_component	proteasome core complex
Q	0005886	cellular_component	plasma membrane
Q	0009274	cellular_component	peptidoglycan-based cell wall
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0019941	biological_process	modification-dependent protein catabolic process
Q	0030682	biological_process	symbiont-mediated perturbation of host defenses
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
R	0004298	molecular_function	threonine-type endopeptidase activity
R	0005839	cellular_component	proteasome core complex
R	0010498	biological_process	proteasomal protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0003824	molecular_function	catalytic activity
S	0004175	molecular_function	endopeptidase activity
S	0004298	molecular_function	threonine-type endopeptidase activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005839	cellular_component	proteasome core complex
S	0005886	cellular_component	plasma membrane
S	0009274	cellular_component	peptidoglycan-based cell wall
S	0010498	biological_process	proteasomal protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0019941	biological_process	modification-dependent protein catabolic process
S	0030682	biological_process	symbiont-mediated perturbation of host defenses
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
T	0004298	molecular_function	threonine-type endopeptidase activity
T	0005839	cellular_component	proteasome core complex
T	0010498	biological_process	proteasomal protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0003824	molecular_function	catalytic activity
U	0004175	molecular_function	endopeptidase activity
U	0004298	molecular_function	threonine-type endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005839	cellular_component	proteasome core complex
U	0005886	cellular_component	plasma membrane
U	0009274	cellular_component	peptidoglycan-based cell wall
U	0010498	biological_process	proteasomal protein catabolic process
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0019941	biological_process	modification-dependent protein catabolic process
U	0030682	biological_process	symbiont-mediated perturbation of host defenses
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0051603	biological_process	proteolysis involved in protein catabolic process
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0010498	biological_process	proteasomal protein catabolic process
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0003824	molecular_function	catalytic activity
W	0004175	molecular_function	endopeptidase activity
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0005839	cellular_component	proteasome core complex
W	0005886	cellular_component	plasma membrane
W	0009274	cellular_component	peptidoglycan-based cell wall
W	0010498	biological_process	proteasomal protein catabolic process
W	0019773	cellular_component	proteasome core complex, alpha-subunit complex
W	0019941	biological_process	modification-dependent protein catabolic process
W	0030682	biological_process	symbiont-mediated perturbation of host defenses
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0004298	molecular_function	threonine-type endopeptidase activity
X	0005839	cellular_component	proteasome core complex
X	0010498	biological_process	proteasomal protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0000502	cellular_component	proteasome complex
Y	0003824	molecular_function	catalytic activity
Y	0004175	molecular_function	endopeptidase activity
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005839	cellular_component	proteasome core complex
Y	0005886	cellular_component	plasma membrane
Y	0009274	cellular_component	peptidoglycan-based cell wall
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Y	0019941	biological_process	modification-dependent protein catabolic process
Y	0030682	biological_process	symbiont-mediated perturbation of host defenses
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005839	cellular_component	proteasome core complex
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF A 249

Chain	Residue
A	GLY77
A	VAL102

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF A 250

Chain	Residue
A	ARG91
A	ARG219
A	HOH1213
H	GLU364
H	HOH2272

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF B 249

Chain	Residue
B	THR106
B	GLY77
B	VAL102

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF B 250

Chain	Residue
B	ARG91
B	ARG219
C	GLU364
C	HOH1685

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF B 251

Chain	Residue
B	THR84
C	VAL361
C	HOH2184

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF C 5

Chain	Residue
C	GLU432
C	GLU434
C	TYR436
C	GLN437
C	LYS447

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF C 15

Chain	Residue
C	TYR472
C	ASP476
E	HOH1090

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF C 17

Chain	Residue
C	ILE336
C	ARG357
C	HOH1355
C	HOH1685

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF C 28

Chain	Residue
C	ARG521
C	HOH554

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF C 43

Chain	Residue
C	ASN381
C	ILE385
I	TYR87
J	ARG357

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF C 48

Chain	Residue
C	ALA377
C	TRP429
J	ARG357
J	HOH2224

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF C 64

Chain	Residue
C	ILE496
C	ASP498
C	HOH2195

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF C 73

Chain	Residue
C	SER441
C	GLY442
C	SER443
C	LEU444
C	PHE445
C	HOH2325

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF D 249

Chain	Residue
D	GLN51
D	SER54
D	ARG75
E	LYS368
E	GLY371
K	ARG97

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF D 250

Chain	Residue
D	TYR87
E	ARG357
R	ASN381

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF D 251

Chain	Residue
D	GLY77
D	TYR103

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF D 252

Chain	Residue
D	ARG91
D	ARG219
E	ALA360
E	GLU364

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF E 32

Chain	Residue
E	TYR472
E	ASP476

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF E 44

Chain	Residue
E	TYR335
E	VAL353
E	ARG357
E	ALA360

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF E 55

Chain	Residue
D	ARG76
E	GLU370
K	ARG85
K	GLN98
K	HOH2288

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF E 70

Chain	Residue
E	ILE380
E	ASN381
E	TRP429
E	HOH2196
L	ARG357

---

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF E 83

Chain	Residue
E	GLU354
E	ARG357
R	ALA377
R	ILE380
R	ASN381
R	TRP429

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF E 95

Chain	Residue
E	TRP429
E	ASN430
E	ILE431
L	ALA349

---

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF F 249

Chain	Residue
F	VAL102
F	TYR103

---

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF F 250

Chain	Residue
F	GLN51
F	ASP72
F	ARG75
G	LEU369
W	ARG97

---

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF G 1

Chain	Residue
G	ARG357
G	TYR335
G	ILE336
G	VAL353

---

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF G 20

Chain	Residue
G	TYR472
G	ALA475
G	ASP476
G	HOH2328
V	HOH866
V	HOH2223

---

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF G 39

Chain	Residue
2	LYS452
G	LYS452

---

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF G 96

Chain	Residue
G	LYS447
G	HOH2284
G	HOH2327
X	ILE326
X	HOH867

---

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF H 14

Chain	Residue
H	ARG521
H	HOH598

---

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF H 19

Chain	Residue
H	HOH2377
L	HOH1904
P	HOH1044

---

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF H 31

Chain	Residue
H	ALA475
H	ASP476
H	HOH553
L	HOH928
L	HOH2384

---

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF H 41

Chain	Residue
A	HOH2428
H	ILE336

---

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF H 52

Chain	Residue
H	VAL487
H	ARG488
H	GLY489

---

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF H 53

Chain	Residue
C	VAL353
H	TRP429
H	ASN430
H	ILE431
H	HOH819

---

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF H 102

Chain	Residue
C	ARG357
H	TRP429

---

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF I 249

Chain	Residue
I	ARG91
I	ARG219
J	ALA360

---

site_id	EC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF I 250

Chain	Residue
I	TYR103

---

site_id	EC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF J 6

Chain	Residue
J	SER320
J	THR321
J	GLY347

---

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF J 59

Chain	Residue
J	ILE336
J	VAL353
J	ARG357
J	HOH1852

---

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF J 82

Chain	Residue
J	TYR472
J	ASP476
J	HOH2332
R	HOH2080

---

site_id	EC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF K 249

Chain	Residue
K	GLY77
K	TYR103

---

site_id	EC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF K 250

Chain	Residue
K	ARG91
K	ARG219
K	HOH2137
L	DMF4
L	VAL361
L	GLU364

---

site_id	EC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF L 4

Chain	Residue
K	DMF250
K	HOH2351
L	ILE336

---

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF L 9

Chain	Residue
H	HOH811
L	TYR472
L	ASP476

---

site_id	FC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF L 60

Chain	Residue
L	ALA377
L	ASN381
L	TRP429
N	GLU354
N	ARG357
N	HOH2035

---

site_id	FC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF M 249

Chain	Residue
M	GLY77
M	VAL102
M	TYR103

---

site_id	FC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF M 250

Chain	Residue
M	ARG91
M	ARG219
M	HOH1926
N	ALA360

---

site_id	FC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF N 2

Chain	Residue
N	HOH134
N	ARG521
N	HOH1467
P	VAL487
P	ARG488
P	HOH2424

---

site_id	FC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF N 21

Chain	Residue
G	GLU354
G	ARG357
N	ALA377
N	ASN381
N	TRP429

---

site_id	FC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF N 24

Chain	Residue
N	TYR335
N	ILE336
N	ALA360

---

site_id	FC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF N 36

Chain	Residue
N	TYR472
N	ASP476

---

site_id	FC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF N 37

Chain	Residue
N	ARG388
N	ASN390
N	ALA425

---

site_id	FC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF N 97

Chain	Residue
N	GLY440
N	SER441
N	SER443
N	LEU444

---

site_id	GC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF N 99

Chain	Residue
G	ALA349
G	HOH890
N	TRP429
N	ASN430
N	ILE431

---

site_id	GC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF O 249

Chain	Residue
O	GLY77
O	VAL102
O	TYR103
O	THR106

---

site_id	GC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF O 250

Chain	Residue
O	ARG91
O	ARG219
O	HOH2047
P	ALA360
P	VAL361
P	GLU364

---

site_id	GC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF P 23

Chain	Residue
P	TYR472
P	ALA475
P	ASP476
P	HOH960

---

site_id	GC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF P 61

Chain	Residue
P	ILE496

---

site_id	GC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF P 74

Chain	Residue
H	GLU354
H	ARG357
P	ALA377
P	ILE380
P	ASN381
P	TRP429

---

site_id	GC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF P 85

Chain	Residue
H	TYR335
H	ALA349
P	TRP429
P	ASN430
P	ILE431

---

site_id	GC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF P 100

Chain	Residue
O	HOH1055
P	ILE336

---

site_id	GC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Q 249

Chain	Residue
Q	GLY77
Q	VAL102
Q	THR106

---

site_id	HC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Q 250

Chain	Residue
D	GLN98
Q	ARG76
R	GLU370

---

site_id	HC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF R 3

Chain	Residue
J	ARG521
R	VAL487
R	ARG488
R	HOH545
Z	HOH1378

---

site_id	HC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF R 54

Chain	Residue
R	TYR335
R	HOH1631

---

site_id	HC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF R 68

Chain	Residue
R	TYR472
R	ALA475
R	ASP476
R	HOH911
R	HOH2425

---

site_id	HC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF R 89

Chain	Residue
Q	ARG91
Q	ARG219
R	ALA360
R	GLU364

---

site_id	HC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF S 249

Chain	Residue
S	GLY77
S	TYR103

---

site_id	HC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF S 250

Chain	Residue
S	ARG91
S	ARG219
T	ALA360

---

site_id	HC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF S 251

Chain	Residue
1	ARG85
1	GLN98
S	ARG76
T	GLU370

---

site_id	HC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF T 35

Chain	Residue
T	ASP338
T	TYR340
T	PRO373
T	LYS379
T	HOH994

---

site_id	IC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF T 46

Chain	Residue
T	TYR335
T	ILE336
T	ALA360

---

site_id	IC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF T 62

Chain	Residue
T	TYR472
T	ALA475
T	ASP476
Z	HOH554

---

site_id	IC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF T 92

Chain	Residue
2	ALA349
2	VAL353
T	TRP429
T	ASN430
T	ILE431

---

site_id	IC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF T 94

Chain	Residue
T	ARG318
T	ASP330
T	ARG332
T	HOH2165

---

site_id	IC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF U 249

Chain	Residue
U	TYR103
U	THR106

---

site_id	IC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF U 250

Chain	Residue
1	ARG76
U	GLN98
U	ASN101
U	VAL102

---

site_id	IC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF U 251

Chain	Residue
U	ARG91
U	ARG219
V	DMF86
V	HOH999
V	HOH2355

---

site_id	IC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF U 252

Chain	Residue
2	ASN381
2	ILE385
2	HOH2315
U	TYR87
U	HOH1610
V	ARG357

---

site_id	IC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF V 16

Chain	Residue
2	HOH2372
V	ARG488
V	HOH2415

---

site_id	JC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF V 86

Chain	Residue
U	DMF251
V	ILE336
V	VAL353
V	ARG357
V	ALA360
V	HOH999

---

site_id	JC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF V 90

Chain	Residue
V	ALA377
V	ILE380
V	ASN381
V	TRP429

---

site_id	JC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF W 249

Chain	Residue
W	ARG76
Y	PHE81
Y	ARG85

---

site_id	JC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF W 250

Chain	Residue
W	TYR103

---

site_id	JC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF X 25

Chain	Residue
X	ILE336

---

site_id	JC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF X 67

Chain	Residue
X	ILE496
X	ASP498
X	VAL503

---

site_id	JC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF X 88

Chain	Residue
W	ARG219
X	ARG357
X	ALA360
X	VAL361
X	HOH2103

---

site_id	JC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Y 249

Chain	Residue
Q	GLN98
Y	ARG76
Z	GLU370

---

site_id	JC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF Z 27

Chain	Residue
Z	TYR472
Z	ASP476
Z	GLY483
Z	HOH2076

---

site_id	KC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Z 50

Chain	Residue
Z	ILE336
Z	ARG357
Z	HOH1148

---

site_id	KC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Z 69

Chain	Residue
Z	ILE496
Z	VAL503
Z	HOH2391

---

site_id	KC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Z 71

Chain	Residue
R	ARG357
Z	TRP429
Z	HOH2095

---

site_id	KC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF Z 79

Chain	Residue
R	TYR335
R	ALA349
R	HOH1034
Z	TRP429
Z	ASN430
Z	ILE431

---

site_id	KC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF Z 91

Chain	Residue
Y	ARG91
Y	ARG219
Z	ALA360
Z	GLU364
Z	HOH1148

---

site_id	KC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF 1 249

Chain	Residue
1	LEU74
1	GLY77
1	TYR103
1	THR106

---

site_id	KC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF 1 250

Chain	Residue
1	THR84
1	HOH1918
2	LEU358

---

site_id	KC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF 1 251

Chain	Residue
1	ARG91
1	ARG219
1	HOH545
2	DMF78
2	ARG357
2	VAL361
2	GLU364

---

site_id	KC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF 2 58

Chain	Residue
2	ALA475
2	GLY483
2	PRO484

---

site_id	LC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF 2 66

Chain	Residue
2	ASP498
2	ARG509

---

site_id	LC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF 2 78

Chain	Residue
1	DMF251
2	TYR335
2	ILE336
2	VAL353
2	HOH2070

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	MOD_RES: N-acetylserine; partial => ECO:0000269|PubMed:17259624, ECO:0007744|PubMed:21969609

Chain	Residue	Details
A	SER2
S	SER2
U	SER2
W	SER2
Y	SER2
1	SER2
B	SER2
D	SER2
F	SER2
I	SER2
K	SER2
M	SER2
O	SER2
Q	SER2

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:25224505

Chain	Residue	Details
A	THR84
F	THR84
F	THR178
F	THR202
I	THR84
I	THR178
I	THR202
K	THR84
K	THR178
K	THR202
M	THR84
A	THR178
M	THR178
M	THR202
O	THR84
O	THR178
O	THR202
Q	THR84
Q	THR178
Q	THR202
S	THR84
S	THR178
A	THR202
S	THR202
U	THR84
U	THR178
U	THR202
W	THR84
W	THR178
W	THR202
Y	THR84
Y	THR178
Y	THR202
B	THR84
1	THR84
1	THR178
1	THR202
B	THR178
B	THR202
D	THR84
D	THR178
D	THR202

---