3H6F

Crystal Structure of Mycobacterium Tuberculosis Proteasome Modified by inhibitor HT1171

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000502	cellular_component	proteasome complex
1	0003824	molecular_function	catalytic activity
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005515	molecular_function	protein binding
1	0005737	cellular_component	cytoplasm
1	0005839	cellular_component	proteasome core complex
1	0005886	cellular_component	plasma membrane
1	0009274	cellular_component	peptidoglycan-based cell wall
1	0010498	biological_process	proteasomal protein catabolic process
1	0019773	cellular_component	proteasome core complex, alpha-subunit complex
1	0019941	biological_process	modification-dependent protein catabolic process
1	0030682	biological_process	symbiont-mediated perturbation of host defenses
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
1	0051603	biological_process	proteolysis involved in protein catabolic process
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005839	cellular_component	proteasome core complex
2	0010498	biological_process	proteasomal protein catabolic process
2	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0003824	molecular_function	catalytic activity
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0010498	biological_process	proteasomal protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0019941	biological_process	modification-dependent protein catabolic process
A	0030682	biological_process	symbiont-mediated perturbation of host defenses
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0003824	molecular_function	catalytic activity
B	0004175	molecular_function	endopeptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0005886	cellular_component	plasma membrane
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0019941	biological_process	modification-dependent protein catabolic process
B	0030682	biological_process	symbiont-mediated perturbation of host defenses
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005839	cellular_component	proteasome core complex
C	0010498	biological_process	proteasomal protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0003824	molecular_function	catalytic activity
D	0004175	molecular_function	endopeptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0005886	cellular_component	plasma membrane
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0019941	biological_process	modification-dependent protein catabolic process
D	0030682	biological_process	symbiont-mediated perturbation of host defenses
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005839	cellular_component	proteasome core complex
E	0010498	biological_process	proteasomal protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0003824	molecular_function	catalytic activity
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0005886	cellular_component	plasma membrane
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0019941	biological_process	modification-dependent protein catabolic process
F	0030682	biological_process	symbiont-mediated perturbation of host defenses
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0004298	molecular_function	threonine-type endopeptidase activity
G	0005839	cellular_component	proteasome core complex
G	0010498	biological_process	proteasomal protein catabolic process
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0010498	biological_process	proteasomal protein catabolic process
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0003824	molecular_function	catalytic activity
I	0004175	molecular_function	endopeptidase activity
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005839	cellular_component	proteasome core complex
I	0005886	cellular_component	plasma membrane
I	0009274	cellular_component	peptidoglycan-based cell wall
I	0010498	biological_process	proteasomal protein catabolic process
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0019941	biological_process	modification-dependent protein catabolic process
I	0030682	biological_process	symbiont-mediated perturbation of host defenses
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0004298	molecular_function	threonine-type endopeptidase activity
J	0005839	cellular_component	proteasome core complex
J	0010498	biological_process	proteasomal protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0003824	molecular_function	catalytic activity
K	0004175	molecular_function	endopeptidase activity
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005839	cellular_component	proteasome core complex
K	0005886	cellular_component	plasma membrane
K	0009274	cellular_component	peptidoglycan-based cell wall
K	0010498	biological_process	proteasomal protein catabolic process
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0019941	biological_process	modification-dependent protein catabolic process
K	0030682	biological_process	symbiont-mediated perturbation of host defenses
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005839	cellular_component	proteasome core complex
L	0010498	biological_process	proteasomal protein catabolic process
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0003824	molecular_function	catalytic activity
M	0004175	molecular_function	endopeptidase activity
M	0004298	molecular_function	threonine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0005886	cellular_component	plasma membrane
M	0009274	cellular_component	peptidoglycan-based cell wall
M	0010498	biological_process	proteasomal protein catabolic process
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0019941	biological_process	modification-dependent protein catabolic process
M	0030682	biological_process	symbiont-mediated perturbation of host defenses
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005839	cellular_component	proteasome core complex
N	0010498	biological_process	proteasomal protein catabolic process
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0003824	molecular_function	catalytic activity
O	0004175	molecular_function	endopeptidase activity
O	0004298	molecular_function	threonine-type endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005839	cellular_component	proteasome core complex
O	0005886	cellular_component	plasma membrane
O	0009274	cellular_component	peptidoglycan-based cell wall
O	0010498	biological_process	proteasomal protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0019941	biological_process	modification-dependent protein catabolic process
O	0030682	biological_process	symbiont-mediated perturbation of host defenses
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
P	0004298	molecular_function	threonine-type endopeptidase activity
P	0005839	cellular_component	proteasome core complex
P	0010498	biological_process	proteasomal protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0003824	molecular_function	catalytic activity
Q	0004175	molecular_function	endopeptidase activity
Q	0004298	molecular_function	threonine-type endopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005839	cellular_component	proteasome core complex
Q	0005886	cellular_component	plasma membrane
Q	0009274	cellular_component	peptidoglycan-based cell wall
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0019941	biological_process	modification-dependent protein catabolic process
Q	0030682	biological_process	symbiont-mediated perturbation of host defenses
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
R	0004298	molecular_function	threonine-type endopeptidase activity
R	0005839	cellular_component	proteasome core complex
R	0010498	biological_process	proteasomal protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0003824	molecular_function	catalytic activity
S	0004175	molecular_function	endopeptidase activity
S	0004298	molecular_function	threonine-type endopeptidase activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005839	cellular_component	proteasome core complex
S	0005886	cellular_component	plasma membrane
S	0009274	cellular_component	peptidoglycan-based cell wall
S	0010498	biological_process	proteasomal protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0019941	biological_process	modification-dependent protein catabolic process
S	0030682	biological_process	symbiont-mediated perturbation of host defenses
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
T	0004298	molecular_function	threonine-type endopeptidase activity
T	0005839	cellular_component	proteasome core complex
T	0010498	biological_process	proteasomal protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0003824	molecular_function	catalytic activity
U	0004175	molecular_function	endopeptidase activity
U	0004298	molecular_function	threonine-type endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005839	cellular_component	proteasome core complex
U	0005886	cellular_component	plasma membrane
U	0009274	cellular_component	peptidoglycan-based cell wall
U	0010498	biological_process	proteasomal protein catabolic process
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0019941	biological_process	modification-dependent protein catabolic process
U	0030682	biological_process	symbiont-mediated perturbation of host defenses
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0051603	biological_process	proteolysis involved in protein catabolic process
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0010498	biological_process	proteasomal protein catabolic process
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0003824	molecular_function	catalytic activity
W	0004175	molecular_function	endopeptidase activity
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0005839	cellular_component	proteasome core complex
W	0005886	cellular_component	plasma membrane
W	0009274	cellular_component	peptidoglycan-based cell wall
W	0010498	biological_process	proteasomal protein catabolic process
W	0019773	cellular_component	proteasome core complex, alpha-subunit complex
W	0019941	biological_process	modification-dependent protein catabolic process
W	0030682	biological_process	symbiont-mediated perturbation of host defenses
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0004298	molecular_function	threonine-type endopeptidase activity
X	0005839	cellular_component	proteasome core complex
X	0010498	biological_process	proteasomal protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0000502	cellular_component	proteasome complex
Y	0003824	molecular_function	catalytic activity
Y	0004175	molecular_function	endopeptidase activity
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005839	cellular_component	proteasome core complex
Y	0005886	cellular_component	plasma membrane
Y	0009274	cellular_component	peptidoglycan-based cell wall
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Y	0019941	biological_process	modification-dependent protein catabolic process
Y	0030682	biological_process	symbiont-mediated perturbation of host defenses
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005839	cellular_component	proteasome core complex
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF A 249

Chain	Residue
A	GLY77
A	THR106

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF B 249

Chain	Residue
B	VAL102
B	THR106

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF B 250

Chain	Residue
B	ARG91
B	ARG219
C	DMF10
C	GLU364

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF C 10

Chain	Residue
C	TYR335
C	ILE336
C	HOH1638
B	DMF250

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF C 38

Chain	Residue
C	ILE496
C	ASP498

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF C 47

Chain	Residue
C	ALA377
C	ASN381
C	TRP429
J	GLU354
J	ARG357

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF C 55

Chain	Residue
C	SER441
C	GLY442
C	SER443
C	LEU444
C	PHE445

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF D 249

Chain	Residue
D	LEU74
D	THR106

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF E 20

Chain	Residue
C	ARG488
E	TYR472
E	ASP476

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF E 28

Chain	Residue
E	ILE336
E	VAL353

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF E 66

Chain	Residue
C	MET325
E	SER441
E	LEU444

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF F 249

Chain	Residue
F	TYR103

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF G 1

Chain	Residue
F	HOH953
G	TYR335
G	ILE336

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF G 12

Chain	Residue
G	TYR472
G	ALA475
G	ASP476
V	HOH1271

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF G 24

Chain	Residue
2	GLN456
G	LYS452

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF G 60

Chain	Residue
G	TRP429
G	ASN430
G	ILE431
X	ALA349

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF G 64

Chain	Residue
G	SER441
G	GLY442
G	SER443
G	LEU444
G	PHE445

---

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF H 26

Chain	Residue
H	ILE336

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF H 32

Chain	Residue
H	VAL487
H	GLY489
L	SER522

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF H 33

Chain	Residue
C	ALA349
H	TRP429
H	ASN430
H	ILE431

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF H 62

Chain	Residue
H	SER441
H	GLY442
H	SER443
H	LEU444
H	PHE445

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF I 249

Chain	Residue
I	ARG91
J	GLU364
J	HOH1221

---

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF I 250

Chain	Residue
I	THR106
I	HOH1323

---

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF J 4

Chain	Residue
J	HOH199
J	OZT301
J	THR321
J	THR348
J	HOH1466

---

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF J 45

Chain	Residue
J	TYR472
J	ASP476

---

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF J 50

Chain	Residue
J	ILE336
J	ARG357

---

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF K 249

Chain	Residue
K	GLY77
K	TYR103

---

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF K 250

Chain	Residue
K	ARG91
K	ARG219
K	HOH1485
L	DMF3
L	VAL361
L	GLU364

---

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF K 251

Chain	Residue
D	ARG76
E	GLU370
K	GLN98

---

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF L 3

Chain	Residue
K	DMF250
L	ILE336

---

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF L 36

Chain	Residue
L	ALA377
L	ASN381
L	TRP429
N	GLU354
N	ARG357

---

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF L 53

Chain	Residue
E	TRP429
L	GLU354
L	ARG357
L	HOH1603
E	ALA377

---

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF M 249

Chain	Residue
M	GLY77
M	VAL102
M	THR106
M	HOH1743

---

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF M 250

Chain	Residue
M	ARG91
M	ARG219
M	HOH1478
N	ALA360
N	GLU364

---

site_id	DC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF N 2

Chain	Residue
N	ARG521
P	VAL487

---

site_id	DC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF N 15

Chain	Residue
N	ILE336
N	VAL353
N	ALA360

---

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF N 22

Chain	Residue
N	TYR472
N	ALA475
N	ASP476
P	HOH1377

---

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF N 58

Chain	Residue
N	SER441
N	SER443
N	LEU444
N	PHE445

---

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF O 249

Chain	Residue
O	GLY77
O	VAL102
O	TYR103
O	THR106

---

site_id	EC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF P 14

Chain	Residue
P	TYR472
P	ALA475
P	ASP476

---

site_id	EC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF P 51

Chain	Residue
P	ILE496
P	ASP498

---

site_id	EC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF P 56

Chain	Residue
H	ARG357
P	ALA377
P	TRP429

---

site_id	EC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF P 65

Chain	Residue
H	ALA349
P	TRP429
P	ASN430
P	ILE431

---

site_id	EC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMF Q 249

Chain	Residue
Q	GLY77
Q	THR106
Q	HOH1696

---

site_id	EC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF R 34

Chain	Residue
R	TYR335
R	ILE336
R	VAL353
R	ALA356
R	ARG357

---

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF R 59

Chain	Residue
R	SER441
R	GLY442
R	SER443
R	LEU444

---

site_id	FC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF S 249

Chain	Residue
S	TYR103
S	THR106

---

site_id	FC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF T 29

Chain	Residue
T	TYR335
T	ILE336
T	ALA360
T	HOH1461
T	HOH1567

---

site_id	FC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMF T 67

Chain	Residue
2	ALA349
2	ALA350
2	HOH899
T	TRP429
T	ASN430
T	ILE431
T	HOH1732

---

site_id	FC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF U 249

Chain	Residue
U	GLY77
U	VAL102
U	TYR103
U	HOH1767

---

site_id	FC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMF V 27

Chain	Residue
V	TYR335
V	ILE336
V	VAL353
V	ARG357

---

site_id	FC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF V 39

Chain	Residue
V	ASP498

---

site_id	FC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF W 249

Chain	Residue
W	LEU74
W	GLY77

---

site_id	FC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF X 16

Chain	Residue
X	DMF61
X	ILE336

---

site_id	GC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF X 40

Chain	Residue
X	ASP498
X	HOH1639

---

site_id	GC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF X 61

Chain	Residue
W	ARG91
X	DMF16
X	ALA360
X	VAL361
X	GLU364

---

site_id	GC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMF Z 18

Chain	Residue
Z	TYR472
Z	ASP476
Z	HOH550
Z	HOH1283
Z	HOH1771

---

site_id	GC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF Z 30

Chain	Residue
Z	ILE336

---

site_id	GC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMF Z 41

Chain	Residue
Z	ASP498

---

site_id	GC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF Z 43

Chain	Residue
R	TYR335
R	ALA349
Z	TRP429
Z	ASN430
Z	ILE431
Z	HOH1030

---

site_id	GC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF Z 54

Chain	Residue
Z	ALA377
Z	TRP429

---

site_id	GC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF 1 249

Chain	Residue
1	THR106
1	HOH1753

---

site_id	GC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF 2 42

Chain	Residue
2	ILE336
2	HOH1793

---

site_id	HC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF 2 49

Chain	Residue
2	ALA475
2	ASP476

---

site_id	HC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMF 2 52

Chain	Residue
2	ASP498
2	ARG509

---

site_id	HC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMF 2 63

Chain	Residue
2	TRP429
2	ASN430
2	ILE431
2	HOH1187
V	TYR335
V	ALA349

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	MOD_RES: N-acetylserine; partial => ECO:0000269|PubMed:17259624, ECO:0007744|PubMed:21969609

Chain	Residue	Details
A	SER2
S	SER2
U	SER2
W	SER2
Y	SER2
1	SER2
B	SER2
D	SER2
F	SER2
I	SER2
K	SER2
M	SER2
O	SER2
Q	SER2

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:25224505

Chain	Residue	Details
A	THR84
F	THR84
F	THR178
F	THR202
I	THR84
I	THR178
I	THR202
K	THR84
K	THR178
K	THR202
M	THR84
A	THR178
M	THR178
M	THR202
O	THR84
O	THR178
O	THR202
Q	THR84
Q	THR178
Q	THR202
S	THR84
S	THR178
A	THR202
S	THR202
U	THR84
U	THR178
U	THR202
W	THR84
W	THR178
W	THR202
Y	THR84
Y	THR178
Y	THR202
B	THR84
1	THR84
1	THR178
1	THR202
B	THR178
B	THR202
D	THR84
D	THR178
D	THR202

---