3H5K

Crystal structure of the ribosome inactivating protein PDL1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006952	biological_process	defense response
A	0016787	molecular_function	hydrolase activity
A	0017148	biological_process	negative regulation of translation
A	0030598	molecular_function	rRNA N-glycosylase activity
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity
B	0006952	biological_process	defense response
B	0016787	molecular_function	hydrolase activity
B	0017148	biological_process	negative regulation of translation
B	0030598	molecular_function	rRNA N-glycosylase activity
B	0035821	biological_process	modulation of process of another organism
B	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS00275
Number of Residues	17
Details	SHIGA_RICIN Shiga/ricin ribosomal inactivating toxins active site signature. IqMVsEAARFKyIEnqV

Chain	Residue	Details
A	ILE170-VAL186

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P84531

Chain	Residue	Details
A	TYR72
A	TYR122
A	GLU175
A	ARG178
B	TYR72
B	TYR122
B	GLU175
B	ARG178

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:20174685, ECO:0007744|PDB:3LE7

Chain	Residue	Details
A	VAL73
A	SER120
A	ARG178
B	VAL73
B	SER120
B	ARG178

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; in PD-L1 and PD-L2 => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:19014994, ECO:0000269|PubMed:19452522, ECO:0000269|PubMed:20174685, ECO:0007744|PDB:3H5K, ECO:0007744|PDB:3LE7

Chain	Residue	Details
A	ASN10
B	ASN10

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; in PD-L1 and PD-L2 => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:10213004, ECO:0000269|PubMed:19014994

Chain	Residue	Details
A	ASN43
B	ASN43

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; in PD-L1 => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:19014994

Chain	Residue	Details
A	ASN255
B	ASN255

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1abr

Chain	Residue	Details
A	GLU175
A	ARG178

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1abr

Chain	Residue	Details
B	GLU175
B	ARG178

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