3H4X

Structure of a Ca+2 dependent Phosphatidylinositol-specific phospholipase C (PI-PLC) Enzyme from Streptomyces antibioticus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004435	molecular_function	phosphatidylinositol-4,5-bisphosphate phospholipase C activity
A	0006629	biological_process	lipid metabolic process
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 340

Chain	Residue
A	THR27
A	GLY29
A	GLY178
A	TRP179
A	HOH636

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EOH A 341

Chain	Residue
A	ARG246
A	ALA248
A	GOL364

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EOH A 342

Chain	Residue
A	HOH755
A	HOH454

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EOH A 343

Chain	Residue
A	ALA92
A	GLU144
A	ALA147
A	HOH597
A	HOH610
A	HOH673
A	HOH674

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EOH A 344

Chain	Residue
A	ARG112
A	ARG150
A	GLN151
A	HOH388

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EOH A 345

Chain	Residue
A	ARG100

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EOH A 346

Chain	Residue
A	ALA67
A	LEU68
A	ASN135
A	GLY138
A	ARG140
A	HOH462

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EOH A 347

Chain	Residue
A	TRP208
A	HOH602
A	HOH754

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EOH A 348

Chain	Residue
A	ASP262
A	ASN290
A	HOH708

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EOH A 349

Chain	Residue
A	ALA105
A	GLY106
A	SER109
A	LYS152
A	EOH355
A	HOH539
A	HOH560
A	HOH582

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EOH A 350

Chain	Residue
A	SER93
A	GLU94
A	LYS225
A	GLN228

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EOH A 351

Chain	Residue
A	PRO119
A	GLY120
A	HOH479

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EOH A 352

Chain	Residue
A	ASP277
A	THR278
A	HIS280
A	HOH443
A	HOH486
A	HOH691

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EOH A 353

Chain	Residue
A	HIS216
A	ACE367
A	ACE368
A	HOH481
A	HOH681

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EOH A 354

Chain	Residue
A	LYS137
A	GLY138
A	GLY139
A	HOH533

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EOH A 355

Chain	Residue
A	ALA105
A	EOH349
A	HOH494
A	HOH501

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EOH A 356

Chain	Residue
A	TYR325
A	PRO326
A	HOH407
A	HOH544

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EOH A 357

Chain	Residue
A	ASN66
A	HIS167
A	HOH503
A	HOH687

---

site_id	CC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EOH A 358

Chain	Residue
A	GLU60
A	LYS127
A	ILE194
A	HIS236
A	ASP260
A	HOH438
A	HOH548
A	HOH747

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EOH A 359

Chain	Residue
A	ALA183
A	ALA186
A	HOH426
A	HOH534

---

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EOH A 360

Chain	Residue
A	GLY81
A	HOH395

---

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 361

Chain	Residue
A	HIS115
A	ASP155
A	HOH420
A	HOH530
A	HOH626

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 362

Chain	Residue
A	ASP262
A	HOH522
A	HOH557
A	HOH658

---

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 363

Chain	Residue
A	PRO293
A	VAL294
A	ILE295
A	GLU304
A	HOH477
A	HOH490
A	HOH613

---

site_id	CC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 364

Chain	Residue
A	ALA239
A	PRO240
A	ASP242
A	PRO243
A	GLU245
A	ARG246
A	ALA248
A	EOH341
A	HOH574
A	HOH592
A	HOH737

---

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 365

Chain	Residue
A	GLN223
A	GLY224
A	LYS225
A	HOH373

---

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 366

Chain	Residue
A	ARG70
A	SER71
A	GLY138
A	GLY139
A	ARG140
A	HOH501
A	HOH643

---

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACE A 367

Chain	Residue
A	SER93
A	ALA143
A	GLU144
A	EOH353
A	ACE368

---

site_id	DC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACE A 368

Chain	Residue
A	ALA136
A	GLY141
A	PRO142
A	ALA143
A	GLU144
A	EOH353
A	ACE367
A	ACE370
A	HOH489

---

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACE A 369

Chain	Residue
A	GLY241
A	ASP242
A	PRO250
A	HOH571
A	HOH580
A	HOH592

---

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACE A 370

Chain	Residue
A	PRO142
A	GLU212
A	ACE368
A	HOH396

---

site_id	DC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACE A 371

Chain	Residue
A	LYS42
A	ASN83
A	ASP101
A	ALA183
A	ASP184
A	HOH452
A	HOH555
A	HOH649

---