3H4D

Ternary complex of human DNA polymerase iota with template U/T and incoming dGTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 871

Chain	Residue
A	ASP34
A	LEU35
A	ASP126
A	MG872
T	DGT875

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 872

Chain	Residue
P	DOC873
T	DGT875
A	ASP34
A	ASP126
A	GLU127
A	MG871

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site_id	AC3
Number of Residues	26
Details	BINDING SITE FOR RESIDUE DGT T 875

Chain	Residue
A	ASP34
A	LEU35
A	ASP36
A	CYS37
A	PHE38
A	TYR39
A	GLN59
A	VAL64
A	THR65
A	TYR68
A	ARG71
A	LYS77
A	ASP126
A	LYS214
A	HOH452
A	HOH475
A	HOH557
A	HOH577
A	MG871
A	MG872
P	DOC873
T	HOH19
T	HOH173
T	HOH234
T	BRU840
T	DG841

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00216

Chain	Residue	Details
A	THR152

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5

Chain	Residue	Details
A	GLN59
A	LYS60
A	VAL151

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N

Chain	Residue	Details
A	VAL64
A	GLY96

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