3GZ3
Leishmania major Dihydroorotate Dehydrogenase in complex with orotate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0006106 | biological_process | fumarate metabolic process |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006222 | biological_process | UMP biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 0097014 | cellular_component | ciliary plasm |
A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0006106 | biological_process | fumarate metabolic process |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0006222 | biological_process | UMP biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0097014 | cellular_component | ciliary plasm |
B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE FMN A 321 |
Chain | Residue |
A | ALA19 |
A | ILE194 |
A | ASN195 |
A | GLY222 |
A | GLY223 |
A | VAL226 |
A | CYS249 |
A | GLY250 |
A | GLY251 |
A | GLY272 |
A | THR273 |
A | ALA20 |
A | ORO322 |
A | HOH342 |
A | HOH345 |
A | HOH357 |
A | HOH361 |
A | GLY21 |
A | LYS44 |
A | SER45 |
A | ASN68 |
A | MET70 |
A | ASN128 |
A | LYS165 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE ORO A 322 |
Chain | Residue |
A | LYS44 |
A | ASN68 |
A | MET70 |
A | GLY71 |
A | LEU72 |
A | ASN128 |
A | ASN195 |
A | SER196 |
A | FMN321 |
A | HOH461 |
A | HOH475 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 323 |
Chain | Residue |
A | ILE203 |
A | HOH393 |
B | LEU227 |
B | LEU231 |
B | HOH425 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 324 |
Chain | Residue |
A | PRO63 |
A | ARG224 |
A | TYR253 |
A | HOH376 |
A | HOH394 |
site_id | AC5 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE FMN B 321 |
Chain | Residue |
B | ALA19 |
B | ALA20 |
B | GLY21 |
B | LYS44 |
B | SER45 |
B | TYR59 |
B | ASN68 |
B | MET70 |
B | ASN128 |
B | LYS165 |
B | ILE194 |
B | ASN195 |
B | GLY222 |
B | GLY223 |
B | VAL226 |
B | CYS249 |
B | GLY250 |
B | GLY251 |
B | GLY272 |
B | THR273 |
B | ORO322 |
B | HOH337 |
B | HOH347 |
B | HOH353 |
site_id | AC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE ORO B 322 |
Chain | Residue |
B | LYS44 |
B | ASN68 |
B | MET70 |
B | GLY71 |
B | LEU72 |
B | ASN128 |
B | ASN195 |
B | SER196 |
B | FMN321 |
B | HOH384 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 323 |
Chain | Residue |
A | LEU227 |
A | LEU231 |
A | LEU260 |
B | ILE203 |
B | HOH421 |
B | HOH483 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 324 |
Chain | Residue |
B | PRO63 |
B | ARG224 |
B | TYR253 |
B | HOH378 |
B | HOH380 |
B | HOH450 |
B | HOH511 |