3GVR

Single-chain UROD Y164G (GY) mutation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004853	molecular_function	uroporphyrinogen decarboxylase activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006778	biological_process	porphyrin-containing compound metabolic process
A	0006779	biological_process	porphyrin-containing compound biosynthetic process
A	0006782	biological_process	protoporphyrinogen IX biosynthetic process
A	0006783	biological_process	heme biosynthetic process
A	0006784	biological_process	heme A biosynthetic process
A	0006785	biological_process	heme B biosynthetic process
A	0006787	biological_process	porphyrin-containing compound catabolic process
A	0016831	molecular_function	carboxy-lyase activity
A	0042168	biological_process	heme metabolic process
A	0048034	biological_process	heme O biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00906
Number of Residues	10
Details	UROD_1 Uroporphyrinogen decarboxylase signature 1. PVWCMRQAGR

Chain	Residue	Details
A	PRO32-ARG41

---

site_id	PS00907
Number of Residues	17
Details	UROD_2 Uroporphyrinogen decarboxylase signature 2. IGFAGaPWTLmtYmv.EG

Chain	Residue	Details
A	ILE152-GLY168

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING:

Chain	Residue	Details
A	GLU27
A	GLU45
A	ARG75
A	PHE76
A	PHE154
A	ALA209
A	GLY329

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Transition state stabilizer

Chain	Residue	Details
A	PHE76

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1uro

Chain	Residue	Details
A	TYR164
A	ASP86

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 914

Chain	Residue	Details
A	GLU27	proton shuttle (general acid/base)
A	THR31	electrostatic stabiliser
A	GLY40	proton shuttle (general acid/base)
A	PHE76	enhance reactivity, modifies pKa, transition state stabiliser
A	PHE154	electrostatic stabiliser

---