3GVP

Human SAHH-like domain of human adenosylhomocysteinase 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004013	molecular_function	adenosylhomocysteinase activity
B	0004013	molecular_function	adenosylhomocysteinase activity
C	0004013	molecular_function	adenosylhomocysteinase activity
D	0004013	molecular_function	adenosylhomocysteinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	BINDING SITE FOR RESIDUE NAD A 608

Chain	Residue
A	ASP369
A	ASP424
A	CYS427
A	CYS454
A	THR455
A	GLY456
A	ASN457
A	MET478
A	GLY479
A	HIS480
A	ASN525
A	ASN370
A	HOH619
A	HOH621
A	HOH656
A	HOH657
A	HOH745
A	HOH755
A	HOH756
A	HOH763
C	LYS605
A	GLY399
A	GLY401
A	GLU402
A	VAL403
A	THR421
A	GLU422
A	ILE423

---

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD B 608

Chain	Residue
B	ASP369
B	ASN370
B	GLY401
B	GLU402
B	VAL403
B	THR421
B	GLU422
B	ILE423
B	ASP424
B	CYS427
B	CYS454
B	THR455
B	GLY456
B	ASN457
B	MET478
B	GLY479
B	HIS480
B	LEU523
B	ASN525
B	HOH696
B	HOH706
B	HOH709
B	HOH741
B	HOH742
D	LYS605

---

site_id	AC3
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAD C 608

Chain	Residue
A	LYS605
C	ASP369
C	ASN370
C	GLY399
C	GLY401
C	GLU402
C	VAL403
C	THR421
C	GLU422
C	ILE423
C	ASP424
C	CYS427
C	CYS454
C	THR455
C	GLY456
C	ASN457
C	VAL460
C	MET478
C	GLY479
C	HIS480
C	LEU523
C	ASN525
C	HOH640
C	HOH657
C	HOH689
C	HOH735
C	HOH762
C	HOH766
C	HOH768

---

site_id	AC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD D 608

Chain	Residue
D	GLY479
D	HIS480
D	LEU523
D	ASN525
D	HOH612
D	HOH686
D	HOH705
D	HOH708
D	HOH739
D	HOH740
B	LYS605
D	ASP369
D	ASN370
D	GLY399
D	GLY401
D	GLU402
D	VAL403
D	THR421
D	GLU422
D	ILE423
D	ASP424
D	CYS427
D	CYS454
D	THR455
D	GLY456
D	ASN457
D	MET478

---

Functional Information from PROSITE/UniProt

site_id	PS00738
Number of Residues	15
Details	ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. ACNiYSTLNeVAAAL

Chain	Residue	Details
A	ALA257-LEU271

---

site_id	PS00739
Number of Residues	18
Details	ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKqvvVcGYGeVGKGccA

Chain	Residue	Details
A	GLY392-ALA409

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2009","submissionDatabase":"PDB data bank","title":"Human S-adenosyl homocysteine hydrolase-like 2 protein crystal structure.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	7
Details	Annotated By Reference To The Literature 1b3r

Chain	Residue	Details
A	HIS480
A	ASP310
A	CYS374
A	HIS234
A	ASN370
A	ASP369
A	LYS365

---

site_id	CSA2
Number of Residues	7
Details	Annotated By Reference To The Literature 1b3r

Chain	Residue	Details
B	HIS480
B	ASP310
B	CYS374
B	HIS234
B	ASN370
B	ASP369
B	LYS365

---

site_id	CSA3
Number of Residues	7
Details	Annotated By Reference To The Literature 1b3r

Chain	Residue	Details
C	HIS480
C	ASP310
C	CYS374
C	HIS234
C	ASN370
C	ASP369
C	LYS365

---

site_id	CSA4
Number of Residues	7
Details	Annotated By Reference To The Literature 1b3r

Chain	Residue	Details
D	HIS480
D	ASP310
D	CYS374
D	HIS234
D	ASN370
D	ASP369
D	LYS365

---