3GVK
Crystal structure of endo-neuraminidase NF mutant
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"BNR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"BNR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"BNR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"15608653","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20096705","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"15608653","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | Site: {"description":"Binding to sialic acid","evidences":[{"source":"PubMed","id":"20096705","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 829 |
| Chain | Residue | Details |
| A | TYR325 | promote heterolysis, proton acceptor, proton donor |
| A | ALA350 | promote heterolysis, proton acceptor, proton donor, proton relay |
| A | GLU581 | activator, electrostatic stabiliser, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| A | ARG596 | electrostatic stabiliser, increase acidity |
| A | ARG647 | electrostatic stabiliser, increase acidity |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 829 |
| Chain | Residue | Details |
| B | TYR325 | promote heterolysis, proton acceptor, proton donor |
| B | ALA350 | promote heterolysis, proton acceptor, proton donor, proton relay |
| B | GLU581 | activator, electrostatic stabiliser, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| B | ARG596 | electrostatic stabiliser, increase acidity |
| B | ARG647 | electrostatic stabiliser, increase acidity |
| site_id | MCSA3 |
| Number of Residues | 5 |
| Details | M-CSA 829 |
| Chain | Residue | Details |
| C | TYR325 | promote heterolysis, proton acceptor, proton donor |
| C | ALA350 | promote heterolysis, proton acceptor, proton donor, proton relay |
| C | GLU581 | activator, electrostatic stabiliser, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| C | ARG596 | electrostatic stabiliser, increase acidity |
| C | ARG647 | electrostatic stabiliser, increase acidity |
