3GV5

Human DNA polymerase iota in complex with T template DNA and incoming ddADP

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003684	molecular_function	damaged DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0006281	biological_process	DNA repair
D	0003684	molecular_function	damaged DNA binding
D	0003887	molecular_function	DNA-directed DNA polymerase activity
D	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B 421

Chain	Residue
B	SER296
B	GLN300
B	HOH647
D	GLN144
D	HOH505
D	HOH527
T	HOH157

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 422

Chain	Residue
B	GLU305
B	ASP306
B	LEU324
B	HOH479
B	HOH750
T	DC841
T	DT842
B	GLU97
B	GLU304

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 423

Chain	Residue
B	LYS237
B	HOH546
B	HOH712
P	HOH312
P	HOH648

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 424

Chain	Residue
B	ASP34
B	LEU35
B	ASP126
B	ADI425
P	HOH279

---

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADI B 425

Chain	Residue
B	ASP34
B	LEU35
B	ASP36
B	CYS37
B	PHE38
B	VAL64
B	THR65
B	TYR68
B	ARG71
B	LYS77
B	ASP126
B	LYS214
B	CA424
B	HOH572
B	HOH579
B	HOH637
P	HOH754
P	DG873
T	DT840

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA P 1

Chain	Residue
B	HOH523
P	HOH751
P	HOH754
P	DA872
T	HOH757

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 421

Chain	Residue
D	ASP34
D	LEU35
D	ASP126
D	CA422
D	ADI424
D	HOH638

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 422

Chain	Residue
D	ASP34
D	GLU127
D	CA421
D	HOH436
D	HOH638
E	DG873

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA D 423

Chain	Residue
B	SER296
B	GLN300
B	HOH647
D	GLN144
D	HOH505
D	HOH527
T	HOH157

---

site_id	BC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADI D 424

Chain	Residue
D	ASP34
D	LEU35
D	ASP36
D	CYS37
D	PHE38
D	VAL64
D	THR65
D	TYR68
D	ARG71
D	LYS77
D	ASP126
D	LYS214
D	CA421
D	HOH436
D	HOH480
D	HOH507
D	HOH649
E	HOH752
E	DG873
F	DT840

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 1

Chain	Residue
D	GLU304
D	HOH525
D	HOH565
F	HOH150
F	DT842

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15254543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27555320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27555320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KT5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15254543","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T3N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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