3GTV

Human-mouse SOD1 chimera

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
A	0006801	biological_process	superoxide metabolic process
A	0046872	molecular_function	metal ion binding
B	0005507	molecular_function	copper ion binding
B	0006801	biological_process	superoxide metabolic process
B	0046872	molecular_function	metal ion binding
C	0005507	molecular_function	copper ion binding
C	0006801	biological_process	superoxide metabolic process
C	0046872	molecular_function	metal ion binding
D	0005507	molecular_function	copper ion binding
D	0006801	biological_process	superoxide metabolic process
D	0046872	molecular_function	metal ion binding
E	0005507	molecular_function	copper ion binding
E	0006801	biological_process	superoxide metabolic process
E	0046872	molecular_function	metal ion binding
F	0005507	molecular_function	copper ion binding
F	0006801	biological_process	superoxide metabolic process
F	0046872	molecular_function	metal ion binding
G	0005507	molecular_function	copper ion binding
G	0006801	biological_process	superoxide metabolic process
G	0046872	molecular_function	metal ion binding
H	0005507	molecular_function	copper ion binding
H	0006801	biological_process	superoxide metabolic process
H	0046872	molecular_function	metal ion binding
I	0005507	molecular_function	copper ion binding
I	0006801	biological_process	superoxide metabolic process
I	0046872	molecular_function	metal ion binding
J	0005507	molecular_function	copper ion binding
J	0006801	biological_process	superoxide metabolic process
J	0046872	molecular_function	metal ion binding
K	0005507	molecular_function	copper ion binding
K	0006801	biological_process	superoxide metabolic process
K	0046872	molecular_function	metal ion binding
L	0005507	molecular_function	copper ion binding
L	0006801	biological_process	superoxide metabolic process
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 155

Chain	Residue
A	HIS63
A	HIS71
A	HIS80
A	ASP83

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 155

Chain	Residue
B	HIS63
B	HIS71
B	HIS80
B	ASP83

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 155

Chain	Residue
C	HIS71
C	HIS80
C	ASP83
C	HIS63

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 155

Chain	Residue
D	HIS63
D	HIS71
D	HIS80
D	ASP83

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN E 155

Chain	Residue
E	HIS63
E	HIS71
E	HIS80
E	ASP83
E	LYS136

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN F 155

Chain	Residue
F	HIS63
F	HIS71
F	HIS80
F	ASP83
F	LYS136

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 155

Chain	Residue
G	HIS63
G	HIS71
G	HIS80
G	ASP83

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 155

Chain	Residue
H	HIS63
H	HIS71
H	HIS80
H	ASP83

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 155

Chain	Residue
I	HIS63
I	HIS71
I	HIS80
I	ASP83

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 155

Chain	Residue
J	HIS63
J	HIS71
J	HIS80
J	ASP83

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 155

Chain	Residue
K	HIS63
K	HIS71
K	HIS80
K	ASP83

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 155

Chain	Residue
L	HIS63
L	HIS71
L	HIS80
L	ASP83

---

Functional Information from PROSITE/UniProt

site_id	PS00087
Number of Residues	11
Details	SOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHEfGDnT

Chain	Residue	Details
A	GLY44-THR54

---

site_id	PS00332
Number of Residues	12
Details	SOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGsRlACgvI

Chain	Residue	Details
A	GLY138-ILE149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:12963370, ECO:0000269|PubMed:17548825

Chain	Residue	Details
A	HIS46
A	HIS48
B	HIS46
B	HIS48
C	HIS46
C	HIS48
D	HIS46
D	HIS48
E	HIS46
E	HIS48
F	HIS46
F	HIS48
G	HIS46
G	HIS48
H	HIS46
H	HIS48
I	HIS46
I	HIS48
J	HIS46
J	HIS48
K	HIS46
K	HIS48
L	HIS46
L	HIS48

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269|PubMed:20727846

Chain	Residue	Details
A	HIS63
A	HIS71
A	HIS80
J	HIS63
J	HIS71
J	HIS80
J	ASP83
K	HIS63
K	HIS71
K	HIS80
K	ASP83
L	HIS63
L	HIS71
L	HIS80
L	ASP83
A	ASP83
B	HIS63
B	HIS71
B	HIS80
B	ASP83
C	HIS63
C	HIS71
C	HIS80
C	ASP83
D	HIS63
D	HIS71
D	HIS80
D	ASP83
E	HIS63
E	HIS71
E	HIS80
E	ASP83
F	HIS63
F	HIS71
F	HIS80
F	ASP83
G	HIS63
G	HIS71
G	HIS80
G	ASP83
H	HIS63
H	HIS71
H	HIS80
H	ASP83
I	HIS63
I	HIS71
I	HIS80
I	ASP83

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:1463506, ECO:0000269|PubMed:7002610, ECO:0007744|PubMed:25944712

Chain	Residue	Details
A	ALA1
B	ALA1
C	ALA1
D	ALA1
E	ALA1
F	ALA1
G	ALA1
H	ALA1
I	ALA1
J	ALA1
K	ALA1
L	ALA1

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P08228

Chain	Residue	Details
G	LYS3
G	LYS9
H	LYS3
H	LYS9
I	LYS3
I	LYS9
J	LYS3
J	LYS9
K	LYS3
K	LYS9
L	LYS3
L	LYS9
A	LYS3
A	LYS9
B	LYS3
B	LYS9
C	LYS3
C	LYS9
D	LYS3
D	LYS9
E	LYS3
E	LYS9
F	LYS3
F	LYS9

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:22496122

Chain	Residue	Details
A	CYS6
B	CYS6
C	CYS6
D	CYS6
E	CYS6
F	CYS6
G	CYS6
H	CYS6
I	CYS6
J	CYS6
K	CYS6
L	CYS6

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	CROSSLNK: 1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33) => ECO:0000269|PubMed:20600836

Chain	Residue	Details
G	TRP32
H	TRP32
I	TRP32
J	TRP32
K	TRP32
L	TRP32
A	TRP32
B	TRP32
C	TRP32
D	TRP32
E	TRP32
F	TRP32

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
B	HIS120
D	HIS120
F	HIS120
H	HIS120
J	HIS120
L	HIS120
A	HIS120
C	HIS120
E	HIS120
G	HIS120
I	HIS120
K	HIS120

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
A	LYS91
B	LYS91
C	LYS91
D	LYS91
E	LYS91
F	LYS91
G	LYS91
H	LYS91
I	LYS91
J	LYS91
K	LYS91
L	LYS91

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00441

Chain	Residue	Details
A	SER98
B	SER98
C	SER98
D	SER98
E	SER98
F	SER98
G	SER98
H	SER98
I	SER98
J	SER98
K	SER98
L	SER98

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07632

Chain	Residue	Details
A	SER105
B	SER105
C	SER105
D	SER105
E	SER105
F	SER105
G	SER105
H	SER105
I	SER105
J	SER105
K	SER105
L	SER105

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	SER107
B	SER107
C	SER107
D	SER107
E	SER107
F	SER107
G	SER107
H	SER107
I	SER107
J	SER107
K	SER107
L	SER107

---

site_id	SWS_FT_FI12
Number of Residues	24
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0007744|PubMed:23806337

Chain	Residue	Details
G	LYS122
G	LYS136
H	LYS122
H	LYS136
I	LYS122
I	LYS136
J	LYS122
J	LYS136
K	LYS122
K	LYS136
L	LYS122
L	LYS136
A	LYS122
A	LYS136
B	LYS122
B	LYS136
C	LYS122
C	LYS136
D	LYS122
D	LYS136
E	LYS122
E	LYS136
F	LYS122
F	LYS136

---