3GLR

Crystal Structure of human SIRT3 with acetyl-lysine AceCS2 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017136	molecular_function	histone deacetylase activity, NAD-dependent
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS256
A	CYS259
A	CYS280
A	CYS283

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	HOH501
A	HOH522
A	HOH18
A	VAL277
A	ARG279
A	ARG384
A	HOH466

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BCT A 4

Chain	Residue
A	ARG135
A	GLN138
A	LYS219
A	GLU382

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 5

Chain	Residue
A	HOH44
A	HIS217
A	GLY220
A	LYS243
A	HOH472

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 2

Chain	Residue
A	HOH42
A	PRO299
A	GLN300
B	SER640

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:16788062

Chain	Residue	Details
B	ALY642

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:23897466

Chain	Residue	Details
A	GLY145
A	GLN228
A	GLY319
A	ASN344

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23897466, ECO:0000269|PubMed:36896611, ECO:0000269|PubMed:37720100

Chain	Residue	Details
A	CYS256
A	CYS259
A	CYS283

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23897466, ECO:0000269|PubMed:36896611

Chain	Residue	Details
A	CYS280

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8R104

Chain	Residue	Details
A	LYS122

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