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3GKL

Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins

Functional Information from GO Data
ChainGOidnamespacecontents
A0004519molecular_functionendonuclease activity
A0005102molecular_functionsignaling receptor binding
A0009617biological_processresponse to bacterium
A0019835biological_processcytolysis
B0004519molecular_functionendonuclease activity
B0005102molecular_functionsignaling receptor binding
B0009617biological_processresponse to bacterium
B0019835biological_processcytolysis
C0005515molecular_functionprotein binding
C0015643molecular_functiontoxic substance binding
C0019904molecular_functionprotein domain specific binding
C0030153biological_processbacteriocin immunity
C0032991cellular_componentprotein-containing complex
D0005515molecular_functionprotein binding
D0015643molecular_functiontoxic substance binding
D0019904molecular_functionprotein domain specific binding
D0030153biological_processbacteriocin immunity
D0032991cellular_componentprotein-containing complex
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZN A 600
ChainResidue
AHIS544
AHIS569
AHIS573

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 600
ChainResidue
BHIS544
BALA545
BHIS569
BHIS573

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING:
ChainResidueDetails
AHIS544
AHIS569
AHIS573
BHIS544
BHIS569
BHIS573

Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 838
ChainResidueDetails
AARG447electrostatic stabiliser, proton acceptor, proton donor, proton relay
AHIS544metal ligand
AALA545proton acceptor, proton donor
AHIS569metal ligand
AHIS573metal ligand

site_idMCSA2
Number of Residues5
DetailsM-CSA 838
ChainResidueDetails
BARG447electrostatic stabiliser, proton acceptor, proton donor, proton relay
BHIS544metal ligand
BALA545proton acceptor, proton donor
BHIS569metal ligand
BHIS573metal ligand

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PDB entries from 2024-11-06

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