3GJ9
crystal structure of TIP-1 in complex with c-terminal of Kir2.3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001650 | cellular_component | fibrillar center |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007266 | biological_process | Rho protein signal transduction |
| A | 0008013 | molecular_function | beta-catenin binding |
| A | 0009966 | biological_process | regulation of signal transduction |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0030178 | biological_process | negative regulation of Wnt signaling pathway |
| A | 0032489 | biological_process | regulation of Cdc42 protein signal transduction |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 2000009 | biological_process | negative regulation of protein localization to cell surface |
| B | 0001650 | cellular_component | fibrillar center |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007266 | biological_process | Rho protein signal transduction |
| B | 0008013 | molecular_function | beta-catenin binding |
| B | 0009966 | biological_process | regulation of signal transduction |
| B | 0016055 | biological_process | Wnt signaling pathway |
| B | 0030178 | biological_process | negative regulation of Wnt signaling pathway |
| B | 0032489 | biological_process | regulation of Cdc42 protein signal transduction |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 2000009 | biological_process | negative regulation of protein localization to cell surface |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 125 |
| Chain | Residue |
| A | HIS19 |
| A | GLU103 |
| B | GLU103 |
| B | ZN125 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 125 |
| Chain | Residue |
| A | GLU103 |
| A | ZN125 |
| B | HIS19 |
| B | GLU103 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 126 |
| Chain | Residue |
| B | GLU62 |
| B | GLU67 |
| B | HOH135 |
| B | HOH164 |
| A | GLU17 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 127 |
| Chain | Residue |
| A | GLU62 |
| A | GLU67 |
| A | HOH128 |
| B | GLU17 |
| B | HOH134 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 126 |
| Chain | Residue |
| A | ARG15 |
| A | GLN79 |
| A | GLY82 |
| A | ARG106 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 127 |
| Chain | Residue |
| A | GLN72 |
| A | ILE73 |
| B | ARG106 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 128 |
| Chain | Residue |
| B | ARG15 |
| B | GLN79 |
| B | GLY82 |
| B | ARG106 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 129 |
| Chain | Residue |
| A | ARG106 |
| B | ILE73 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 194 |
| Details | Domain: {"description":"PDZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Motif: {"description":"PDZ-binding","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
