3GHG

Crystal Structure of Human Fibrinogen

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005102	molecular_function	signaling receptor binding
A	0005577	cellular_component	fibrinogen complex
A	0007596	biological_process	blood coagulation
A	0030168	biological_process	platelet activation
A	0051258	biological_process	protein polymerization
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0005102	molecular_function	signaling receptor binding
B	0005198	molecular_function	structural molecule activity
B	0005201	molecular_function	extracellular matrix structural constituent
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005577	cellular_component	fibrinogen complex
B	0005615	cellular_component	extracellular space
B	0005783	cellular_component	endoplasmic reticulum
B	0005886	cellular_component	plasma membrane
B	0005938	cellular_component	cell cortex
B	0007160	biological_process	cell-matrix adhesion
B	0007596	biological_process	blood coagulation
B	0007599	biological_process	hemostasis
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0030168	biological_process	platelet activation
B	0031012	cellular_component	extracellular matrix
B	0031091	cellular_component	platelet alpha granule
B	0031093	cellular_component	platelet alpha granule lumen
B	0031639	biological_process	plasminogen activation
B	0034116	biological_process	positive regulation of heterotypic cell-cell adhesion
B	0042730	biological_process	fibrinolysis
B	0043152	biological_process	induction of bacterial agglutination
B	0044320	biological_process	cellular response to leptin stimulus
B	0045087	biological_process	innate immune response
B	0045202	cellular_component	synapse
B	0045907	biological_process	positive regulation of vasoconstriction
B	0045921	biological_process	positive regulation of exocytosis
B	0050714	biological_process	positive regulation of protein secretion
B	0050839	molecular_function	cell adhesion molecule binding
B	0051087	molecular_function	protein-folding chaperone binding
B	0051258	biological_process	protein polymerization
B	0051592	biological_process	response to calcium ion
B	0065003	biological_process	protein-containing complex assembly
B	0070062	cellular_component	extracellular exosome
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0070527	biological_process	platelet aggregation
B	0071347	biological_process	cellular response to interleukin-1
B	0072378	biological_process	blood coagulation, fibrin clot formation
B	0072562	cellular_component	blood microparticle
B	0090277	biological_process	positive regulation of peptide hormone secretion
B	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
B	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B	1903561	cellular_component	extracellular vesicle
B	2000352	biological_process	negative regulation of endothelial cell apoptotic process
C	0005102	molecular_function	signaling receptor binding
C	0005198	molecular_function	structural molecule activity
C	0005201	molecular_function	extracellular matrix structural constituent
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005577	cellular_component	fibrinogen complex
C	0005615	cellular_component	extracellular space
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005886	cellular_component	plasma membrane
C	0007160	biological_process	cell-matrix adhesion
C	0007596	biological_process	blood coagulation
C	0007599	biological_process	hemostasis
C	0009306	biological_process	protein secretion
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0030168	biological_process	platelet activation
C	0031012	cellular_component	extracellular matrix
C	0031091	cellular_component	platelet alpha granule
C	0031093	cellular_component	platelet alpha granule lumen
C	0031639	biological_process	plasminogen activation
C	0034116	biological_process	positive regulation of heterotypic cell-cell adhesion
C	0042730	biological_process	fibrinolysis
C	0045907	biological_process	positive regulation of vasoconstriction
C	0045921	biological_process	positive regulation of exocytosis
C	0046872	molecular_function	metal ion binding
C	0050714	biological_process	positive regulation of protein secretion
C	0050839	molecular_function	cell adhesion molecule binding
C	0051258	biological_process	protein polymerization
C	0051592	biological_process	response to calcium ion
C	0065003	biological_process	protein-containing complex assembly
C	0070062	cellular_component	extracellular exosome
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0070527	biological_process	platelet aggregation
C	0072378	biological_process	blood coagulation, fibrin clot formation
C	0072562	cellular_component	blood microparticle
C	0090277	biological_process	positive regulation of peptide hormone secretion
C	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
C	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
C	2000352	biological_process	negative regulation of endothelial cell apoptotic process
D	0005102	molecular_function	signaling receptor binding
D	0005577	cellular_component	fibrinogen complex
D	0007596	biological_process	blood coagulation
D	0030168	biological_process	platelet activation
D	0051258	biological_process	protein polymerization
E	0002250	biological_process	adaptive immune response
E	0002376	biological_process	immune system process
E	0005102	molecular_function	signaling receptor binding
E	0005198	molecular_function	structural molecule activity
E	0005201	molecular_function	extracellular matrix structural constituent
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005577	cellular_component	fibrinogen complex
E	0005615	cellular_component	extracellular space
E	0005783	cellular_component	endoplasmic reticulum
E	0005886	cellular_component	plasma membrane
E	0005938	cellular_component	cell cortex
E	0007160	biological_process	cell-matrix adhesion
E	0007596	biological_process	blood coagulation
E	0007599	biological_process	hemostasis
E	0009897	cellular_component	external side of plasma membrane
E	0009986	cellular_component	cell surface
E	0030168	biological_process	platelet activation
E	0031012	cellular_component	extracellular matrix
E	0031091	cellular_component	platelet alpha granule
E	0031093	cellular_component	platelet alpha granule lumen
E	0031639	biological_process	plasminogen activation
E	0034116	biological_process	positive regulation of heterotypic cell-cell adhesion
E	0042730	biological_process	fibrinolysis
E	0043152	biological_process	induction of bacterial agglutination
E	0044320	biological_process	cellular response to leptin stimulus
E	0045087	biological_process	innate immune response
E	0045202	cellular_component	synapse
E	0045907	biological_process	positive regulation of vasoconstriction
E	0045921	biological_process	positive regulation of exocytosis
E	0050714	biological_process	positive regulation of protein secretion
E	0050839	molecular_function	cell adhesion molecule binding
E	0051087	molecular_function	protein-folding chaperone binding
E	0051258	biological_process	protein polymerization
E	0051592	biological_process	response to calcium ion
E	0065003	biological_process	protein-containing complex assembly
E	0070062	cellular_component	extracellular exosome
E	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
E	0070527	biological_process	platelet aggregation
E	0071347	biological_process	cellular response to interleukin-1
E	0072378	biological_process	blood coagulation, fibrin clot formation
E	0072562	cellular_component	blood microparticle
E	0090277	biological_process	positive regulation of peptide hormone secretion
E	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
E	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
E	1903561	cellular_component	extracellular vesicle
E	2000352	biological_process	negative regulation of endothelial cell apoptotic process
F	0005102	molecular_function	signaling receptor binding
F	0005198	molecular_function	structural molecule activity
F	0005201	molecular_function	extracellular matrix structural constituent
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005577	cellular_component	fibrinogen complex
F	0005615	cellular_component	extracellular space
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005886	cellular_component	plasma membrane
F	0007160	biological_process	cell-matrix adhesion
F	0007596	biological_process	blood coagulation
F	0007599	biological_process	hemostasis
F	0009306	biological_process	protein secretion
F	0009897	cellular_component	external side of plasma membrane
F	0009986	cellular_component	cell surface
F	0030168	biological_process	platelet activation
F	0031012	cellular_component	extracellular matrix
F	0031091	cellular_component	platelet alpha granule
F	0031093	cellular_component	platelet alpha granule lumen
F	0031639	biological_process	plasminogen activation
F	0034116	biological_process	positive regulation of heterotypic cell-cell adhesion
F	0042730	biological_process	fibrinolysis
F	0045907	biological_process	positive regulation of vasoconstriction
F	0045921	biological_process	positive regulation of exocytosis
F	0046872	molecular_function	metal ion binding
F	0050714	biological_process	positive regulation of protein secretion
F	0050839	molecular_function	cell adhesion molecule binding
F	0051258	biological_process	protein polymerization
F	0051592	biological_process	response to calcium ion
F	0065003	biological_process	protein-containing complex assembly
F	0070062	cellular_component	extracellular exosome
F	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
F	0070527	biological_process	platelet aggregation
F	0072378	biological_process	blood coagulation, fibrin clot formation
F	0072562	cellular_component	blood microparticle
F	0090277	biological_process	positive regulation of peptide hormone secretion
F	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
F	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
F	2000352	biological_process	negative regulation of endothelial cell apoptotic process
G	0005102	molecular_function	signaling receptor binding
G	0005577	cellular_component	fibrinogen complex
G	0007596	biological_process	blood coagulation
G	0030168	biological_process	platelet activation
G	0051258	biological_process	protein polymerization
H	0002250	biological_process	adaptive immune response
H	0002376	biological_process	immune system process
H	0005102	molecular_function	signaling receptor binding
H	0005198	molecular_function	structural molecule activity
H	0005201	molecular_function	extracellular matrix structural constituent
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005577	cellular_component	fibrinogen complex
H	0005615	cellular_component	extracellular space
H	0005783	cellular_component	endoplasmic reticulum
H	0005886	cellular_component	plasma membrane
H	0005938	cellular_component	cell cortex
H	0007160	biological_process	cell-matrix adhesion
H	0007596	biological_process	blood coagulation
H	0007599	biological_process	hemostasis
H	0009897	cellular_component	external side of plasma membrane
H	0009986	cellular_component	cell surface
H	0030168	biological_process	platelet activation
H	0031012	cellular_component	extracellular matrix
H	0031091	cellular_component	platelet alpha granule
H	0031093	cellular_component	platelet alpha granule lumen
H	0031639	biological_process	plasminogen activation
H	0034116	biological_process	positive regulation of heterotypic cell-cell adhesion
H	0042730	biological_process	fibrinolysis
H	0043152	biological_process	induction of bacterial agglutination
H	0044320	biological_process	cellular response to leptin stimulus
H	0045087	biological_process	innate immune response
H	0045202	cellular_component	synapse
H	0045907	biological_process	positive regulation of vasoconstriction
H	0045921	biological_process	positive regulation of exocytosis
H	0050714	biological_process	positive regulation of protein secretion
H	0050839	molecular_function	cell adhesion molecule binding
H	0051087	molecular_function	protein-folding chaperone binding
H	0051258	biological_process	protein polymerization
H	0051592	biological_process	response to calcium ion
H	0065003	biological_process	protein-containing complex assembly
H	0070062	cellular_component	extracellular exosome
H	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
H	0070527	biological_process	platelet aggregation
H	0071347	biological_process	cellular response to interleukin-1
H	0072378	biological_process	blood coagulation, fibrin clot formation
H	0072562	cellular_component	blood microparticle
H	0090277	biological_process	positive regulation of peptide hormone secretion
H	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
H	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
H	1903561	cellular_component	extracellular vesicle
H	2000352	biological_process	negative regulation of endothelial cell apoptotic process
I	0005102	molecular_function	signaling receptor binding
I	0005198	molecular_function	structural molecule activity
I	0005201	molecular_function	extracellular matrix structural constituent
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005577	cellular_component	fibrinogen complex
I	0005615	cellular_component	extracellular space
I	0005788	cellular_component	endoplasmic reticulum lumen
I	0005886	cellular_component	plasma membrane
I	0007160	biological_process	cell-matrix adhesion
I	0007596	biological_process	blood coagulation
I	0007599	biological_process	hemostasis
I	0009306	biological_process	protein secretion
I	0009897	cellular_component	external side of plasma membrane
I	0009986	cellular_component	cell surface
I	0030168	biological_process	platelet activation
I	0031012	cellular_component	extracellular matrix
I	0031091	cellular_component	platelet alpha granule
I	0031093	cellular_component	platelet alpha granule lumen
I	0031639	biological_process	plasminogen activation
I	0034116	biological_process	positive regulation of heterotypic cell-cell adhesion
I	0042730	biological_process	fibrinolysis
I	0045907	biological_process	positive regulation of vasoconstriction
I	0045921	biological_process	positive regulation of exocytosis
I	0046872	molecular_function	metal ion binding
I	0050714	biological_process	positive regulation of protein secretion
I	0050839	molecular_function	cell adhesion molecule binding
I	0051258	biological_process	protein polymerization
I	0051592	biological_process	response to calcium ion
I	0065003	biological_process	protein-containing complex assembly
I	0070062	cellular_component	extracellular exosome
I	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
I	0070527	biological_process	platelet aggregation
I	0072378	biological_process	blood coagulation, fibrin clot formation
I	0072562	cellular_component	blood microparticle
I	0090277	biological_process	positive regulation of peptide hormone secretion
I	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
I	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
I	2000352	biological_process	negative regulation of endothelial cell apoptotic process
J	0005102	molecular_function	signaling receptor binding
J	0005577	cellular_component	fibrinogen complex
J	0007596	biological_process	blood coagulation
J	0030168	biological_process	platelet activation
J	0051258	biological_process	protein polymerization
K	0002250	biological_process	adaptive immune response
K	0002376	biological_process	immune system process
K	0005102	molecular_function	signaling receptor binding
K	0005198	molecular_function	structural molecule activity
K	0005201	molecular_function	extracellular matrix structural constituent
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005577	cellular_component	fibrinogen complex
K	0005615	cellular_component	extracellular space
K	0005783	cellular_component	endoplasmic reticulum
K	0005886	cellular_component	plasma membrane
K	0005938	cellular_component	cell cortex
K	0007160	biological_process	cell-matrix adhesion
K	0007596	biological_process	blood coagulation
K	0007599	biological_process	hemostasis
K	0009897	cellular_component	external side of plasma membrane
K	0009986	cellular_component	cell surface
K	0030168	biological_process	platelet activation
K	0031012	cellular_component	extracellular matrix
K	0031091	cellular_component	platelet alpha granule
K	0031093	cellular_component	platelet alpha granule lumen
K	0031639	biological_process	plasminogen activation
K	0034116	biological_process	positive regulation of heterotypic cell-cell adhesion
K	0042730	biological_process	fibrinolysis
K	0043152	biological_process	induction of bacterial agglutination
K	0044320	biological_process	cellular response to leptin stimulus
K	0045087	biological_process	innate immune response
K	0045202	cellular_component	synapse
K	0045907	biological_process	positive regulation of vasoconstriction
K	0045921	biological_process	positive regulation of exocytosis
K	0050714	biological_process	positive regulation of protein secretion
K	0050839	molecular_function	cell adhesion molecule binding
K	0051087	molecular_function	protein-folding chaperone binding
K	0051258	biological_process	protein polymerization
K	0051592	biological_process	response to calcium ion
K	0065003	biological_process	protein-containing complex assembly
K	0070062	cellular_component	extracellular exosome
K	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
K	0070527	biological_process	platelet aggregation
K	0071347	biological_process	cellular response to interleukin-1
K	0072378	biological_process	blood coagulation, fibrin clot formation
K	0072562	cellular_component	blood microparticle
K	0090277	biological_process	positive regulation of peptide hormone secretion
K	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
K	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
K	1903561	cellular_component	extracellular vesicle
K	2000352	biological_process	negative regulation of endothelial cell apoptotic process
L	0005102	molecular_function	signaling receptor binding
L	0005198	molecular_function	structural molecule activity
L	0005201	molecular_function	extracellular matrix structural constituent
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005577	cellular_component	fibrinogen complex
L	0005615	cellular_component	extracellular space
L	0005788	cellular_component	endoplasmic reticulum lumen
L	0005886	cellular_component	plasma membrane
L	0007160	biological_process	cell-matrix adhesion
L	0007596	biological_process	blood coagulation
L	0007599	biological_process	hemostasis
L	0009306	biological_process	protein secretion
L	0009897	cellular_component	external side of plasma membrane
L	0009986	cellular_component	cell surface
L	0030168	biological_process	platelet activation
L	0031012	cellular_component	extracellular matrix
L	0031091	cellular_component	platelet alpha granule
L	0031093	cellular_component	platelet alpha granule lumen
L	0031639	biological_process	plasminogen activation
L	0034116	biological_process	positive regulation of heterotypic cell-cell adhesion
L	0042730	biological_process	fibrinolysis
L	0045907	biological_process	positive regulation of vasoconstriction
L	0045921	biological_process	positive regulation of exocytosis
L	0046872	molecular_function	metal ion binding
L	0050714	biological_process	positive regulation of protein secretion
L	0050839	molecular_function	cell adhesion molecule binding
L	0051258	biological_process	protein polymerization
L	0051592	biological_process	response to calcium ion
L	0065003	biological_process	protein-containing complex assembly
L	0070062	cellular_component	extracellular exosome
L	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
L	0070527	biological_process	platelet aggregation
L	0072378	biological_process	blood coagulation, fibrin clot formation
L	0072562	cellular_component	blood microparticle
L	0090277	biological_process	positive regulation of peptide hormone secretion
L	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
L	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
L	2000352	biological_process	negative regulation of endothelial cell apoptotic process

Functional Information from PROSITE/UniProt

site_id	PS00514
Number of Residues	13
Details	FIBRINOGEN_C_1 Fibrinogen C-terminal domain signature. WWMnkChaGhlNG

Chain	Residue	Details
C	TRP334-GLY346
B	TRP402-GLY414

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Site: {"description":"Cleavage; by plasmin; to break down fibrin clots"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Site: {"description":"Cleavage; by hementin; to prevent blood coagulation"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2008
Details	Domain: {"description":"Fibrinogen C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00739","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	260
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"10074346","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19296670","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9628725","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10074346","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9628725","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"book","publicationDate":"1980","firstPage":"51","lastPage":"56","publisher":"Pergamon Press","address":"Oxford","bookName":"Protides of the biological fluids, Proc. 28th colloquium","title":"Human fibrinogen: sequence, sulfur bridges, glycosylation and some structural variants.","editors":["Peeters H."],"authors":["Henschen A.","Lottspeich F.","Southan C.","Topfer-Petersen E."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10074346","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19296670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9016719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9207064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9333233","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9628725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FID","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; in variant Asahi"}

Chain

Residue

Details

---