3GE1
2.7 Angstrom Crystal Structure of Glycerol Kinase (glpK) from Staphylococcus aureus in Complex with ADP and Glycerol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004370 | molecular_function | glycerol kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006071 | biological_process | glycerol metabolic process |
| A | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| A | 0019563 | biological_process | glycerol catabolic process |
| B | 0004370 | molecular_function | glycerol kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006071 | biological_process | glycerol metabolic process |
| B | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016310 | biological_process | phosphorylation |
| B | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| B | 0019563 | biological_process | glycerol catabolic process |
| C | 0004370 | molecular_function | glycerol kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006071 | biological_process | glycerol metabolic process |
| C | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016310 | biological_process | phosphorylation |
| C | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| C | 0019563 | biological_process | glycerol catabolic process |
| D | 0004370 | molecular_function | glycerol kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006071 | biological_process | glycerol metabolic process |
| D | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016310 | biological_process | phosphorylation |
| D | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| D | 0019563 | biological_process | glycerol catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP A 499 |
| Chain | Residue |
| A | GLY11 |
| A | GLN313 |
| A | ALA325 |
| A | PRO326 |
| A | GLY410 |
| A | ASN414 |
| A | HOH535 |
| A | HOH566 |
| A | HOH567 |
| A | THR12 |
| A | THR13 |
| A | ARG16 |
| A | GLY265 |
| A | THR266 |
| A | GLY309 |
| A | SER310 |
| A | ILE312 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 500 |
| Chain | Residue |
| A | ARG82 |
| A | GLU83 |
| A | TRP102 |
| A | TYR134 |
| A | ASP244 |
| A | GLN245 |
| A | PHE269 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 A 501 |
| Chain | Residue |
| A | ARG320 |
| B | TYR331 |
| B | LYS372 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 A 502 |
| Chain | Residue |
| A | TYR331 |
| A | LYS372 |
| B | ARG320 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 503 |
| Chain | Residue |
| A | LYS171 |
| A | GLY174 |
| A | LYS175 |
| A | TYR229 |
| A | HIS230 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 504 |
| Chain | Residue |
| A | SER337 |
| A | THR338 |
| A | GLU381 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP B 499 |
| Chain | Residue |
| B | GLY11 |
| B | THR12 |
| B | THR13 |
| B | ARG16 |
| B | GLY265 |
| B | THR266 |
| B | GLY309 |
| B | SER310 |
| B | ILE312 |
| B | GLN313 |
| B | ALA325 |
| B | PRO326 |
| B | GLY410 |
| B | ALA411 |
| B | LYS413 |
| B | ASN414 |
| B | HOH519 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 500 |
| Chain | Residue |
| B | ARG82 |
| B | GLU83 |
| B | TRP102 |
| B | TYR134 |
| B | ASP244 |
| B | GLN245 |
| B | PHE269 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 501 |
| Chain | Residue |
| B | LYS171 |
| B | GLY174 |
| B | LYS175 |
| B | ILE227 |
| B | TYR229 |
| B | HIS230 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 502 |
| Chain | Residue |
| B | SER337 |
| B | THR338 |
| B | GLU381 |
| site_id | BC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP C 499 |
| Chain | Residue |
| C | GLY11 |
| C | THR12 |
| C | THR13 |
| C | ARG16 |
| C | GLY265 |
| C | THR266 |
| C | GLY309 |
| C | ILE312 |
| C | GLN313 |
| C | ALA325 |
| C | PRO326 |
| C | GLY410 |
| C | ALA411 |
| C | ASN414 |
| C | GOL500 |
| C | HOH510 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL C 500 |
| Chain | Residue |
| C | GLN81 |
| C | ARG82 |
| C | GLU83 |
| C | TRP102 |
| C | TYR134 |
| C | ASP244 |
| C | GLN245 |
| C | PHE269 |
| C | ADP499 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 C 501 |
| Chain | Residue |
| C | ILE227 |
| C | TYR229 |
| C | HIS230 |
| C | HOH547 |
| C | LYS171 |
| C | GLY174 |
| C | LYS175 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 502 |
| Chain | Residue |
| C | SER337 |
| C | THR338 |
| C | GLU381 |
| site_id | BC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP D 499 |
| Chain | Residue |
| D | GLY11 |
| D | THR12 |
| D | ARG16 |
| D | GLY265 |
| D | THR266 |
| D | GLY309 |
| D | SER310 |
| D | ILE312 |
| D | ALA325 |
| D | PRO326 |
| D | GLY410 |
| D | ALA411 |
| D | LYS413 |
| D | ASN414 |
| D | HOH545 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 500 |
| Chain | Residue |
| D | GLN81 |
| D | ARG82 |
| D | GLU83 |
| D | TRP102 |
| D | TYR134 |
| D | ASP244 |
| D | GLN245 |
| D | PHE269 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 D 501 |
| Chain | Residue |
| C | ARG320 |
| D | TYR331 |
| D | LYS372 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 D 502 |
| Chain | Residue |
| C | TYR331 |
| C | LYS372 |
| D | ARG320 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 D 503 |
| Chain | Residue |
| D | LYS171 |
| D | GLY174 |
| D | LYS175 |
| D | ILE227 |
| D | TYR229 |
| D | HIS230 |
| D | HOH506 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL D 504 |
| Chain | Residue |
| D | SER337 |
| D | THR338 |
| D | ARG377 |
| D | GLU381 |
Functional Information from PROSITE/UniProt
| site_id | PS00445 |
| Number of Residues | 21 |
| Details | FGGY_KINASES_2 FGGY family of carbohydrate kinases signature 2. GaIFGLtrgteke.HFIRATLE |
| Chain | Residue | Details |
| A | GLY361-GLU381 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00186 |
| Chain | Residue | Details |
| A | THR12 | |
| A | GLN313 | |
| A | GLY410 | |
| B | THR12 | |
| B | THR13 | |
| B | SER14 | |
| B | ARG82 | |
| B | GLU83 | |
| B | TYR134 | |
| B | ASP244 | |
| B | THR266 | |
| A | THR13 | |
| B | GLY309 | |
| B | GLN313 | |
| B | GLY410 | |
| C | THR12 | |
| C | THR13 | |
| C | SER14 | |
| C | ARG82 | |
| C | GLU83 | |
| C | TYR134 | |
| C | ASP244 | |
| A | SER14 | |
| C | THR266 | |
| C | GLY309 | |
| C | GLN313 | |
| C | GLY410 | |
| D | THR12 | |
| D | THR13 | |
| D | SER14 | |
| D | ARG82 | |
| D | GLU83 | |
| D | TYR134 | |
| A | ARG82 | |
| D | ASP244 | |
| D | THR266 | |
| D | GLY309 | |
| D | GLN313 | |
| D | GLY410 | |
| A | GLU83 | |
| A | TYR134 | |
| A | ASP244 | |
| A | THR266 | |
| A | GLY309 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00186, ECO:0000269|Ref.3, ECO:0007744|PDB:3GE1 |
| Chain | Residue | Details |
| A | ARG16 | |
| A | ASN414 | |
| B | ARG16 | |
| B | ASN414 | |
| C | ARG16 | |
| C | ASN414 | |
| D | ARG16 | |
| D | ASN414 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00186, ECO:0000269|Ref.2, ECO:0000269|Ref.3, ECO:0007744|PDB:3G25, ECO:0007744|PDB:3GE1 |
| Chain | Residue | Details |
| A | GLN245 | |
| B | GLN245 | |
| C | GLN245 | |
| D | GLN245 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphohistidine; by HPr => ECO:0000255|HAMAP-Rule:MF_00186 |
| Chain | Residue | Details |
| A | HIS230 | |
| B | HIS230 | |
| C | HIS230 | |
| D | HIS230 |
