3GE1
2.7 Angstrom Crystal Structure of Glycerol Kinase (glpK) from Staphylococcus aureus in Complex with ADP and Glycerol
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004370 | molecular_function | glycerol kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005829 | cellular_component | cytosol |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006071 | biological_process | glycerol metabolic process |
A | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
A | 0019563 | biological_process | glycerol catabolic process |
B | 0004370 | molecular_function | glycerol kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005829 | cellular_component | cytosol |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0006071 | biological_process | glycerol metabolic process |
B | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
B | 0016301 | molecular_function | kinase activity |
B | 0016310 | biological_process | phosphorylation |
B | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
B | 0019563 | biological_process | glycerol catabolic process |
C | 0004370 | molecular_function | glycerol kinase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0005829 | cellular_component | cytosol |
C | 0005975 | biological_process | carbohydrate metabolic process |
C | 0006071 | biological_process | glycerol metabolic process |
C | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
C | 0016301 | molecular_function | kinase activity |
C | 0016310 | biological_process | phosphorylation |
C | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
C | 0019563 | biological_process | glycerol catabolic process |
D | 0004370 | molecular_function | glycerol kinase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0005829 | cellular_component | cytosol |
D | 0005975 | biological_process | carbohydrate metabolic process |
D | 0006071 | biological_process | glycerol metabolic process |
D | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
D | 0016301 | molecular_function | kinase activity |
D | 0016310 | biological_process | phosphorylation |
D | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
D | 0019563 | biological_process | glycerol catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE ADP A 499 |
Chain | Residue |
A | GLY11 |
A | GLN313 |
A | ALA325 |
A | PRO326 |
A | GLY410 |
A | ASN414 |
A | HOH535 |
A | HOH566 |
A | HOH567 |
A | THR12 |
A | THR13 |
A | ARG16 |
A | GLY265 |
A | THR266 |
A | GLY309 |
A | SER310 |
A | ILE312 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 500 |
Chain | Residue |
A | ARG82 |
A | GLU83 |
A | TRP102 |
A | TYR134 |
A | ASP244 |
A | GLN245 |
A | PHE269 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PO4 A 501 |
Chain | Residue |
A | ARG320 |
B | TYR331 |
B | LYS372 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PO4 A 502 |
Chain | Residue |
A | TYR331 |
A | LYS372 |
B | ARG320 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PO4 A 503 |
Chain | Residue |
A | LYS171 |
A | GLY174 |
A | LYS175 |
A | TYR229 |
A | HIS230 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 504 |
Chain | Residue |
A | SER337 |
A | THR338 |
A | GLU381 |
site_id | AC7 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE ADP B 499 |
Chain | Residue |
B | GLY11 |
B | THR12 |
B | THR13 |
B | ARG16 |
B | GLY265 |
B | THR266 |
B | GLY309 |
B | SER310 |
B | ILE312 |
B | GLN313 |
B | ALA325 |
B | PRO326 |
B | GLY410 |
B | ALA411 |
B | LYS413 |
B | ASN414 |
B | HOH519 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 500 |
Chain | Residue |
B | ARG82 |
B | GLU83 |
B | TRP102 |
B | TYR134 |
B | ASP244 |
B | GLN245 |
B | PHE269 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PO4 B 501 |
Chain | Residue |
B | LYS171 |
B | GLY174 |
B | LYS175 |
B | ILE227 |
B | TYR229 |
B | HIS230 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B 502 |
Chain | Residue |
B | SER337 |
B | THR338 |
B | GLU381 |
site_id | BC2 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE ADP C 499 |
Chain | Residue |
C | GLY11 |
C | THR12 |
C | THR13 |
C | ARG16 |
C | GLY265 |
C | THR266 |
C | GLY309 |
C | ILE312 |
C | GLN313 |
C | ALA325 |
C | PRO326 |
C | GLY410 |
C | ALA411 |
C | ASN414 |
C | GOL500 |
C | HOH510 |
site_id | BC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL C 500 |
Chain | Residue |
C | GLN81 |
C | ARG82 |
C | GLU83 |
C | TRP102 |
C | TYR134 |
C | ASP244 |
C | GLN245 |
C | PHE269 |
C | ADP499 |
site_id | BC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 C 501 |
Chain | Residue |
C | ILE227 |
C | TYR229 |
C | HIS230 |
C | HOH547 |
C | LYS171 |
C | GLY174 |
C | LYS175 |
site_id | BC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL C 502 |
Chain | Residue |
C | SER337 |
C | THR338 |
C | GLU381 |
site_id | BC6 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE ADP D 499 |
Chain | Residue |
D | GLY11 |
D | THR12 |
D | ARG16 |
D | GLY265 |
D | THR266 |
D | GLY309 |
D | SER310 |
D | ILE312 |
D | ALA325 |
D | PRO326 |
D | GLY410 |
D | ALA411 |
D | LYS413 |
D | ASN414 |
D | HOH545 |
site_id | BC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL D 500 |
Chain | Residue |
D | GLN81 |
D | ARG82 |
D | GLU83 |
D | TRP102 |
D | TYR134 |
D | ASP244 |
D | GLN245 |
D | PHE269 |
site_id | BC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PO4 D 501 |
Chain | Residue |
C | ARG320 |
D | TYR331 |
D | LYS372 |
site_id | BC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PO4 D 502 |
Chain | Residue |
C | TYR331 |
C | LYS372 |
D | ARG320 |
site_id | CC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 D 503 |
Chain | Residue |
D | LYS171 |
D | GLY174 |
D | LYS175 |
D | ILE227 |
D | TYR229 |
D | HIS230 |
D | HOH506 |
site_id | CC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL D 504 |
Chain | Residue |
D | SER337 |
D | THR338 |
D | ARG377 |
D | GLU381 |
Functional Information from PROSITE/UniProt
site_id | PS00445 |
Number of Residues | 21 |
Details | FGGY_KINASES_2 FGGY family of carbohydrate kinases signature 2. GaIFGLtrgteke.HFIRATLE |
Chain | Residue | Details |
A | GLY361-GLU381 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 44 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00186 |
Chain | Residue | Details |
A | THR12 | |
A | GLN313 | |
A | GLY410 | |
B | THR12 | |
B | THR13 | |
B | SER14 | |
B | ARG82 | |
B | GLU83 | |
B | TYR134 | |
B | ASP244 | |
B | THR266 | |
A | THR13 | |
B | GLY309 | |
B | GLN313 | |
B | GLY410 | |
C | THR12 | |
C | THR13 | |
C | SER14 | |
C | ARG82 | |
C | GLU83 | |
C | TYR134 | |
C | ASP244 | |
A | SER14 | |
C | THR266 | |
C | GLY309 | |
C | GLN313 | |
C | GLY410 | |
D | THR12 | |
D | THR13 | |
D | SER14 | |
D | ARG82 | |
D | GLU83 | |
D | TYR134 | |
A | ARG82 | |
D | ASP244 | |
D | THR266 | |
D | GLY309 | |
D | GLN313 | |
D | GLY410 | |
A | GLU83 | |
A | TYR134 | |
A | ASP244 | |
A | THR266 | |
A | GLY309 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00186, ECO:0000269|Ref.3, ECO:0007744|PDB:3GE1 |
Chain | Residue | Details |
A | ARG16 | |
A | ASN414 | |
B | ARG16 | |
B | ASN414 | |
C | ARG16 | |
C | ASN414 | |
D | ARG16 | |
D | ASN414 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00186, ECO:0000269|Ref.2, ECO:0000269|Ref.3, ECO:0007744|PDB:3G25, ECO:0007744|PDB:3GE1 |
Chain | Residue | Details |
A | GLN245 | |
B | GLN245 | |
C | GLN245 | |
D | GLN245 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: Phosphohistidine; by HPr => ECO:0000255|HAMAP-Rule:MF_00186 |
Chain | Residue | Details |
A | HIS230 | |
B | HIS230 | |
C | HIS230 | |
D | HIS230 |