3GD8

Crystal Structure of Human Aquaporin 4 at 1.8 and its Mechanism of Conductance

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015267	molecular_function	channel activity
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00221
Number of Residues	9
Details	MIP MIP family signature. HINPAVTVA

Chain	Residue	Details
A	HIS95-ALA103

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	119
Details	TRANSMEM: Helical => ECO:0000269|PubMed:19383790

Chain	Residue	Details
A	ALA37-ILE57
A	MET70-GLY89
A	VAL116-VAL136
A	ALA156-ALA176
A	VAL185-ILE205
A	ILE232-PHE252

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site_id	SWS_FT_FI2
Number of Residues	39
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:19383790

Chain	Residue	Details
A	ASN58-ASP69
A	THR137-THR155
A	ASN206-THR208
A	ILE223-TRP231

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site_id	SWS_FT_FI3
Number of Residues	23
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:19383790

Chain	Residue	Details
A	HIS90-GLY93
A	VAL102-SER115
A	SER177-ASP184

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site_id	SWS_FT_FI4
Number of Residues	20
Details	INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:19383790

Chain	Residue	Details
A	GLY94-THR101
A	GLY209-VAL222

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000250|UniProtKB:P55088

Chain	Residue	Details
A	SER111

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:P47863

Chain	Residue	Details
A	SER180

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN153
A	ASN206

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