3GD8

Crystal Structure of Human Aquaporin 4 at 1.8 and its Mechanism of Conductance

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015267	molecular_function	channel activity
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00221
Number of Residues	9
Details	MIP MIP family signature. HINPAVTVA

Chain	Residue	Details
A	HIS95-ALA103

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	119
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"19383790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	39
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"19383790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	23
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"19383790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	20
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"19383790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Motif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"19383790","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Motif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"19383790","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"UniProtKB","id":"P55088","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"UniProtKB","id":"P47863","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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