3GD4
Crystal structure of the reduced, NAD-bound form of murine apoptosis inducing factor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 43 |
| Details | BINDING SITE FOR RESIDUE FAD A 1611 |
| Chain | Residue |
| A | ILE136 |
| A | ARG171 |
| A | PRO172 |
| A | LEU174 |
| A | SER175 |
| A | LYS230 |
| A | LYS231 |
| A | VAL232 |
| A | ALA258 |
| A | THR259 |
| A | GLY260 |
| A | GLY137 |
| A | GLY261 |
| A | PHE283 |
| A | ARG284 |
| A | LEU310 |
| A | ASN402 |
| A | GLY436 |
| A | ASP437 |
| A | GLU452 |
| A | HIS453 |
| A | HIS454 |
| A | GLY138 |
| A | ALA457 |
| A | PHE481 |
| A | TRP482 |
| A | HOH622 |
| A | HOH626 |
| A | HOH627 |
| A | HOH633 |
| A | HOH668 |
| A | HOH687 |
| A | NAD700 |
| A | GLY139 |
| A | HOH767 |
| A | HOH776 |
| A | HOH777 |
| A | HOH856 |
| A | THR140 |
| A | ALA141 |
| A | VAL161 |
| A | SER162 |
| A | GLU163 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NAD A 700 |
| Chain | Residue |
| A | LEU266 |
| A | GLY307 |
| A | GLY308 |
| A | PHE309 |
| A | LEU310 |
| A | GLU313 |
| A | PHE333 |
| A | PRO334 |
| A | GLU335 |
| A | LYS341 |
| A | ALA396 |
| A | VAL397 |
| A | GLY398 |
| A | GLU452 |
| A | HIS453 |
| A | TRP482 |
| A | SER483 |
| A | HOH614 |
| A | HOH631 |
| A | HOH636 |
| A | HOH653 |
| A | HOH720 |
| A | HOH776 |
| A | HOH808 |
| A | FAD1611 |
| site_id | AC3 |
| Number of Residues | 41 |
| Details | BINDING SITE FOR RESIDUE FAD B 1611 |
| Chain | Residue |
| B | HOH635 |
| B | HOH645 |
| B | HOH666 |
| B | NAD700 |
| B | HOH701 |
| B | HOH760 |
| B | HOH785 |
| B | HOH831 |
| B | HOH859 |
| B | HOH982 |
| B | ILE136 |
| B | GLY137 |
| B | GLY138 |
| B | GLY139 |
| B | THR140 |
| B | ALA141 |
| B | VAL161 |
| B | GLU163 |
| B | ARG171 |
| B | PRO172 |
| B | SER175 |
| B | LYS231 |
| B | VAL232 |
| B | ALA258 |
| B | THR259 |
| B | GLY260 |
| B | PHE283 |
| B | ARG284 |
| B | LEU310 |
| B | ASN402 |
| B | GLY436 |
| B | ASP437 |
| B | GLU452 |
| B | HIS453 |
| B | HIS454 |
| B | ALA457 |
| B | PHE481 |
| B | TRP482 |
| B | HOH615 |
| B | HOH616 |
| B | HOH627 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAD B 700 |
| Chain | Residue |
| B | LEU266 |
| B | GLY307 |
| B | GLY308 |
| B | PHE309 |
| B | LEU310 |
| B | GLU313 |
| B | PHE333 |
| B | PRO334 |
| B | GLU335 |
| B | LYS341 |
| B | ALA396 |
| B | VAL397 |
| B | GLY398 |
| B | GLU452 |
| B | HIS453 |
| B | TRP482 |
| B | SER483 |
| B | HOH630 |
| B | HOH638 |
| B | HOH659 |
| B | HOH750 |
| B | HOH762 |
| B | HOH868 |
| B | FAD1611 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 698 |
| Details | Region: {"description":"FAD-dependent oxidoreductase"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11967568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19447115","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GD3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GD4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11967568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19447115","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GD4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11967568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19447115","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GD3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O95831","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19447115","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GD4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19447115","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GD3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GD4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O95831","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23576753","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"O95831","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
