3GD1

Structure of an Arrestin/Clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000822	molecular_function	inositol hexakisphosphate binding
C	0001664	molecular_function	G protein-coupled receptor binding
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
C	0002031	biological_process	G protein-coupled receptor internalization
C	0002092	biological_process	positive regulation of receptor internalization
C	0005515	molecular_function	protein binding
C	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005905	cellular_component	clathrin-coated pit
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007165	biological_process	signal transduction
C	0007601	biological_process	visual perception
C	0009968	biological_process	negative regulation of signal transduction
C	0015031	biological_process	protein transport
C	0030132	cellular_component	clathrin coat of coated pit
C	0030276	molecular_function	clathrin binding
C	0031143	cellular_component	pseudopodium
C	0031410	cellular_component	cytoplasmic vesicle
C	0031623	biological_process	receptor internalization
C	0032050	molecular_function	clathrin heavy chain binding
C	0033130	molecular_function	acetylcholine receptor binding
C	0035612	molecular_function	AP-2 adaptor complex binding
C	0036094	molecular_function	small molecule binding
C	0042995	cellular_component	cell projection
C	0045746	biological_process	negative regulation of Notch signaling pathway
C	0060090	molecular_function	molecular adaptor activity
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0072583	biological_process	clathrin-dependent endocytosis
E	0000822	molecular_function	inositol hexakisphosphate binding
E	0001664	molecular_function	G protein-coupled receptor binding
E	0001934	biological_process	positive regulation of protein phosphorylation
E	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
E	0002031	biological_process	G protein-coupled receptor internalization
E	0002092	biological_process	positive regulation of receptor internalization
E	0005515	molecular_function	protein binding
E	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005905	cellular_component	clathrin-coated pit
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0007165	biological_process	signal transduction
E	0007601	biological_process	visual perception
E	0009968	biological_process	negative regulation of signal transduction
E	0015031	biological_process	protein transport
E	0030132	cellular_component	clathrin coat of coated pit
E	0030276	molecular_function	clathrin binding
E	0031143	cellular_component	pseudopodium
E	0031410	cellular_component	cytoplasmic vesicle
E	0031623	biological_process	receptor internalization
E	0032050	molecular_function	clathrin heavy chain binding
E	0033130	molecular_function	acetylcholine receptor binding
E	0035612	molecular_function	AP-2 adaptor complex binding
E	0036094	molecular_function	small molecule binding
E	0042995	cellular_component	cell projection
E	0045746	biological_process	negative regulation of Notch signaling pathway
E	0060090	molecular_function	molecular adaptor activity
E	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
E	0072583	biological_process	clathrin-dependent endocytosis
I	0005198	molecular_function	structural molecule activity
I	0006886	biological_process	intracellular protein transport
I	0016192	biological_process	vesicle-mediated transport
I	0030130	cellular_component	clathrin coat of trans-Golgi network vesicle
I	0030132	cellular_component	clathrin coat of coated pit

Functional Information from PROSITE/UniProt

site_id	PS00295
Number of Residues	19
Details	ARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL

Chain	Residue	Details
C	PHE61-LEU79

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site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. AEEL

Chain	Residue	Details
I	ALA360-LEU363

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:Q00610

Chain	Residue	Details
I	ALA2
C	MET255
C	LYS324
C	LYS326
E	LYS250
E	MET255
E	LYS324
E	LYS326

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q00610

Chain	Residue	Details
I	SER67
E	TYR47

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q68FD5

Chain	Residue	Details
I	THR105

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q68FD5

Chain	Residue	Details
I	TYR184

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