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3G43

Crystal structure of the calmodulin-bound Cav1.2 C-terminal regulatory domain dimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0000086biological_processG2/M transition of mitotic cell cycle
A0000922cellular_componentspindle pole
A0002027biological_processregulation of heart rate
A0005509molecular_functioncalcium ion binding
A0005513biological_processdetection of calcium ion
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005876cellular_componentspindle microtubule
A0005886cellular_componentplasma membrane
A0007186biological_processG protein-coupled receptor signaling pathway
A0008076cellular_componentvoltage-gated potassium channel complex
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
A0010856molecular_functionadenylate cyclase activator activity
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0016020cellular_componentmembrane
A0016240biological_processautophagosome membrane docking
A0019855molecular_functioncalcium channel inhibitor activity
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0030017cellular_componentsarcomere
A0031432molecular_functiontitin binding
A0031514cellular_componentmotile cilium
A0031954biological_processpositive regulation of protein autophosphorylation
A0031982cellular_componentvesicle
A0032465biological_processregulation of cytokinesis
A0032516biological_processpositive regulation of phosphoprotein phosphatase activity
A0032991cellular_componentprotein-containing complex
A0034704cellular_componentcalcium channel complex
A0035307biological_processpositive regulation of protein dephosphorylation
A0035458biological_processcellular response to interferon-beta
A0043209cellular_componentmyelin sheath
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0044325molecular_functiontransmembrane transporter binding
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046872molecular_functionmetal ion binding
A0048306molecular_functioncalcium-dependent protein binding
A0050848biological_processregulation of calcium-mediated signaling
A0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
A0051592biological_processresponse to calcium ion
A0055117biological_processregulation of cardiac muscle contraction
A0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
A0071346biological_processcellular response to type II interferon
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0072542molecular_functionprotein phosphatase activator activity
A0097225cellular_componentsperm midpiece
A0098901biological_processregulation of cardiac muscle cell action potential
A0140056biological_processorganelle localization by membrane tethering
A1901842biological_processnegative regulation of high voltage-gated calcium channel activity
A1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
A1902494cellular_componentcatalytic complex
A1905913biological_processnegative regulation of calcium ion export across plasma membrane
A1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
B0000086biological_processG2/M transition of mitotic cell cycle
B0000922cellular_componentspindle pole
B0002027biological_processregulation of heart rate
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005876cellular_componentspindle microtubule
B0005886cellular_componentplasma membrane
B0007186biological_processG protein-coupled receptor signaling pathway
B0008076cellular_componentvoltage-gated potassium channel complex
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
B0010856molecular_functionadenylate cyclase activator activity
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0016020cellular_componentmembrane
B0016240biological_processautophagosome membrane docking
B0019855molecular_functioncalcium channel inhibitor activity
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030017cellular_componentsarcomere
B0031432molecular_functiontitin binding
B0031514cellular_componentmotile cilium
B0031954biological_processpositive regulation of protein autophosphorylation
B0031982cellular_componentvesicle
B0032465biological_processregulation of cytokinesis
B0032516biological_processpositive regulation of phosphoprotein phosphatase activity
B0032991cellular_componentprotein-containing complex
B0034704cellular_componentcalcium channel complex
B0035307biological_processpositive regulation of protein dephosphorylation
B0035458biological_processcellular response to interferon-beta
B0043209cellular_componentmyelin sheath
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0044325molecular_functiontransmembrane transporter binding
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0050848biological_processregulation of calcium-mediated signaling
B0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
B0051592biological_processresponse to calcium ion
B0055117biological_processregulation of cardiac muscle contraction
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
B0071346biological_processcellular response to type II interferon
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0072542molecular_functionprotein phosphatase activator activity
B0097225cellular_componentsperm midpiece
B0098901biological_processregulation of cardiac muscle cell action potential
B0140056biological_processorganelle localization by membrane tethering
B1901842biological_processnegative regulation of high voltage-gated calcium channel activity
B1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
B1902494cellular_componentcatalytic complex
B1905913biological_processnegative regulation of calcium ion export across plasma membrane
B1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
C0000086biological_processG2/M transition of mitotic cell cycle
C0000922cellular_componentspindle pole
C0002027biological_processregulation of heart rate
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005876cellular_componentspindle microtubule
C0005886cellular_componentplasma membrane
C0007186biological_processG protein-coupled receptor signaling pathway
C0008076cellular_componentvoltage-gated potassium channel complex
C0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
C0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
C0010856molecular_functionadenylate cyclase activator activity
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0016020cellular_componentmembrane
C0016240biological_processautophagosome membrane docking
C0019855molecular_functioncalcium channel inhibitor activity
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030017cellular_componentsarcomere
C0031432molecular_functiontitin binding
C0031514cellular_componentmotile cilium
C0031954biological_processpositive regulation of protein autophosphorylation
C0031982cellular_componentvesicle
C0032465biological_processregulation of cytokinesis
C0032516biological_processpositive regulation of phosphoprotein phosphatase activity
C0032991cellular_componentprotein-containing complex
C0034704cellular_componentcalcium channel complex
C0035307biological_processpositive regulation of protein dephosphorylation
C0035458biological_processcellular response to interferon-beta
C0043209cellular_componentmyelin sheath
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0044325molecular_functiontransmembrane transporter binding
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050848biological_processregulation of calcium-mediated signaling
C0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
C0051592biological_processresponse to calcium ion
C0055117biological_processregulation of cardiac muscle contraction
C0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
C0071346biological_processcellular response to type II interferon
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0072542molecular_functionprotein phosphatase activator activity
C0097225cellular_componentsperm midpiece
C0098901biological_processregulation of cardiac muscle cell action potential
C0140056biological_processorganelle localization by membrane tethering
C1901842biological_processnegative regulation of high voltage-gated calcium channel activity
C1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
C1902494cellular_componentcatalytic complex
C1905913biological_processnegative regulation of calcium ion export across plasma membrane
C1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
D0000086biological_processG2/M transition of mitotic cell cycle
D0000922cellular_componentspindle pole
D0002027biological_processregulation of heart rate
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005876cellular_componentspindle microtubule
D0005886cellular_componentplasma membrane
D0007186biological_processG protein-coupled receptor signaling pathway
D0008076cellular_componentvoltage-gated potassium channel complex
D0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
D0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
D0010856molecular_functionadenylate cyclase activator activity
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0016020cellular_componentmembrane
D0016240biological_processautophagosome membrane docking
D0019855molecular_functioncalcium channel inhibitor activity
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030017cellular_componentsarcomere
D0031432molecular_functiontitin binding
D0031514cellular_componentmotile cilium
D0031954biological_processpositive regulation of protein autophosphorylation
D0031982cellular_componentvesicle
D0032465biological_processregulation of cytokinesis
D0032516biological_processpositive regulation of phosphoprotein phosphatase activity
D0032991cellular_componentprotein-containing complex
D0034704cellular_componentcalcium channel complex
D0035307biological_processpositive regulation of protein dephosphorylation
D0035458biological_processcellular response to interferon-beta
D0043209cellular_componentmyelin sheath
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0044325molecular_functiontransmembrane transporter binding
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050848biological_processregulation of calcium-mediated signaling
D0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
D0051592biological_processresponse to calcium ion
D0055117biological_processregulation of cardiac muscle contraction
D0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
D0071346biological_processcellular response to type II interferon
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0072542molecular_functionprotein phosphatase activator activity
D0097225cellular_componentsperm midpiece
D0098901biological_processregulation of cardiac muscle cell action potential
D0140056biological_processorganelle localization by membrane tethering
D1901842biological_processnegative regulation of high voltage-gated calcium channel activity
D1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
D1902494cellular_componentcatalytic complex
D1905913biological_processnegative regulation of calcium ion export across plasma membrane
D1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 701
ChainResidue
AASP20
AASP22
AASP24
ATHR26
AGLU31
AHOH151

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 702
ChainResidue
ATHR62
AGLU67
AHOH165
AASP56
AASP58
AASN60

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 703
ChainResidue
BASP129
BASP131
BASP133
BGLN135
BGLU140
BHOH230

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 704
ChainResidue
BASP93
BASP95
BASN97
BTYR99
BGLU104
BHOH205

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE CA B 705
ChainResidue
BASP56
BASP58
BASN60
BTHR62
BGLU67
BHOH169
BHOH171

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 706
ChainResidue
BASP20
BASP22
BASP24
BTHR26
BGLU31
BHOH398

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 707
ChainResidue
CASP129
CASP131
CASP133
CGLN135
CGLU140
CHOH245

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 708
ChainResidue
CASP93
CASP95
CASN97
CTYR99
CGLU104
CHOH176

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 709
ChainResidue
CASP56
CASP58
CASN60
CTHR62
CGLU67
CHOH443

site_idBC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 710
ChainResidue
CASP20
CASP22
CASP24
CTHR26
CGLU31
CHOH157

site_idBC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 711
ChainResidue
DASP93
DASP95
DASN97
DTYR99
DGLU104
DHOH374

site_idBC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 712
ChainResidue
DASP129
DASP131
DASP133
DGLN135
DGLU140
DHOH172

site_idBC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 713
ChainResidue
DASP20
DASP22
DASP24
DTHR26
DGLU31
DHOH186

site_idBC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 714
ChainResidue
DASP56
DASP58
DASN60
DTHR62
DGLU67
DHOH258

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
AASP20-LEU32
AASP56-PHE68
AASP93-LEU105
AASP129-PHE141

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
ChainResidueDetails
AASP20
AGLU67
BASP20
BASP22
BASP24
BTHR26
BGLU31
BASP56
BASP58
BASN60
BTHR62
AASP22
BGLU67
CASP20
CASP22
CASP24
CTHR26
CGLU31
CASP56
CASP58
CASN60
CTHR62
AASP24
CGLU67
DASP20
DASP22
DASP24
DTHR26
DGLU31
DASP56
DASP58
DASN60
DTHR62
ATHR26
DGLU67
AGLU31
AASP56
AASP58
AASN60
ATHR62

site_idSWS_FT_FI2
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
ChainResidueDetails
AASP93
AGLU140
BASP93
BASP95
BASN97
BTYR99
BGLU104
BASP129
BASP131
BASP133
BGLN135
AASP95
BGLU140
CASP93
CASP95
CASN97
CTYR99
CGLU104
CASP129
CASP131
CASP133
CGLN135
AASN97
CGLU140
DASP93
DASP95
DASN97
DTYR99
DGLU104
DASP129
DASP131
DASP133
DGLN135
ATYR99
DGLU140
AGLU104
AASP129
AASP131
AASP133
AGLN135

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
AALA1
BALA1
CALA1
DALA1

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS21
BLYS21
CLYS21
DLYS21

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29
ChainResidueDetails
ATHR44
BTHR44
CTHR44
DTHR44

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER81
BSER81
CSER81
DSER81

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS94
BLYS94
CLYS94
DLYS94

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR99
BTYR99
CTYR99
DTYR99

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER101
BSER101
CSER101
DSER101

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR110
BTHR110
CTHR110
DTHR110

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
ALYS115
BLYS115
CLYS115
DLYS115

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR138
BTYR138
CTYR138
DTYR138

site_idSWS_FT_FI13
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
ALYS21
BLYS21
CLYS21
DLYS21

221716

PDB entries from 2024-06-26

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